WormBase Tree Display for Gene: WBGene00004286

WBGene00004286 SMap: S_parent: Sequence: D2013
  Identity: Version: 1
    Name: CGC_name: rab-39 Person_evidence: WBPerson451
      Sequence_name: D2013.1
      Molecular_name: D2013.1
        D2013.1.1
        CE30340
      Other_name: CELE_D2013.1 Accession_evidence: NDB BX284602
      Public_name: rab-39
    DB_info: Database: AceView gene 2J612
        WormQTL gene WBGene00004286
        WormFlux gene WBGene00004286
        NDB locus_tag CELE_D2013.1
        Panther gene CAEEL|WormBase=WBGene00004286|UniProtKB=Q18969
          family PTHR47979
        NCBI gene 183941
        RefSeq protein NM_063583.4
        SwissProt UniProtAcc Q18969
        UniProt_GCRP UniProtAcc Q18969
        OMIM gene 300774
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rab
    Allele (29)
    Strain: WBStrain00055386
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog: WBGene00062267 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039266 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00143888 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00104342 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00132213 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00223291 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6772 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6126 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g10607 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g14350 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g21953 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16701 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4204 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g16089 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8164 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1692 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00586.g12514 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-rab-39 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold562.g3942 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_04685.g33508 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_24263 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_004721 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g08586 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g13980 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g18097 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20301600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g5452 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00247357 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266899 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287280 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296870 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0029959 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1983 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050417-172 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-070620-7 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-061215-104 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-131127-261 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-131121-578 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      HGNC:16521 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:16499 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1915040 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2441753 Mus musculus From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      MGI:2442855 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1311286 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1593983 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
    Paralog (32)
    Structured_description: Concise_description: rab-39 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab39 GTPases; by homology, RAB-39 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-39 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-39 in C. elegans development and/or behavior is not yet known. Paper_evidence (3)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables GTP binding activity. Involved in positive regulation of response to oxidative stress. Predicted to be located in Golgi apparatus; cytoplasmic vesicle membrane; and plasma membrane. Expressed in head mesodermal cell; head neurons; hypodermis; rectal gland cell; and tail neurons. Human ortholog(s) of this gene implicated in Waisman syndrome and non-syndromic X-linked intellectual disability 72. Is an ortholog of human RAB39A (RAB39A, member RAS oncogene family) and RAB39B (RAB39B, member RAS oncogene family). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112059 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16499)
      DOID:0111781 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16499)
  Molecular_info: Corresponding_CDS: D2013.1
    Corresponding_CDS_history: D2013.1:wp74
    Corresponding_transcript: D2013.1.1
    Other_sequence (25)
    Associated_feature: WBsf650420
      WBsf650421
      WBsf223635
  Experimental_info: RNAi_result: WBRNAi00101872 Inferred_automatically: RNAi_primary
      WBRNAi00107759 Inferred_automatically: RNAi_primary
      WBRNAi00091937 Inferred_automatically: RNAi_primary
      WBRNAi00012560 Inferred_automatically: RNAi_primary
      WBRNAi00030377 Inferred_automatically: RNAi_primary
      WBRNAi00112237 Inferred_automatically: RNAi_primary
      WBRNAi00107758 Inferred_automatically: RNAi_primary
      WBRNAi00043437 Inferred_automatically: RNAi_primary
      WBRNAi00101873 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11318
      Expr1021236
      Expr1032121
      Expr1147433
      Expr2015226
      Expr2033460
    Drives_construct: WBCnstr00018768
      WBCnstr00035586
    Construct_product: WBCnstr00035586
    Microarray_results (18)
    Expression_cluster (95)
    Interaction (23)
  Map_info: Map: II Position: 1.15927 Error: 0.011529
    Positive: Positive_clone: D2013 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00029101
    WBPaper00030935
    WBPaper00038491
    WBPaper00041898
    WBPaper00055090
    WBPaper00058949
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene