WormBase Tree Display for Gene: WBGene00004036

WBGene00004036 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: plc-1 Person_evidence: WBPerson51
            WBPerson1983
      Sequence_name: F31B12.1
      Molecular_name (36)
      Other_name: PLC210 Paper_evidence: WBPaper00003022
            WBPaper00003365
            WBPaper00003875
            WBPaper00003432
            WBPaper00023291
        frm-9 Curator_confirmed: WBPerson4025
        CELE_F31B12.1 Accession_evidence: NDB BX284606
      Public_name: plc-1
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 May 2019 14:10:26 WBPerson1983 Name_change: CGC_name: plc-1
                Other_name: frm-9
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: plc
    Allele (621)
    Strain: WBStrain00002612
      WBStrain00030932
      WBStrain00030933
      WBStrain00051732
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog: WBGene00037171 Caenorhabditis briggsae From_analysis (5)
      WBGene00058405 Caenorhabditis remanei From_analysis (3)
      WBGene00156261 Caenorhabditis brenneri From_analysis (4)
      WBGene00122248 Caenorhabditis japonica From_analysis (3)
      WBGene00223977 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3555 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14488 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP28.g5521 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g15961 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g21792 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g21794 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g2089 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18696 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8494 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g19907 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00373.g9941 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_X.g23381 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g23383 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13810 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00044.g2337 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00044.g2339 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01253 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_023645 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g00727 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g20719 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0076800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19952 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00079584 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00241961 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00110242 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00265806 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285930 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-061212-4 Danio rerio From_analysis (8)
      HGNC:17175 Homo sapiens From_analysis (9)
      MGI:1921305 Mus musculus From_analysis (9)
      RGD:69424 Rattus norvegicus From_analysis (9)
    Paralog: WBGene00001177 Caenorhabditis elegans From_analysis (2)
      WBGene00004045 Caenorhabditis elegans From_analysis (2)
      WBGene00004037 Caenorhabditis elegans From_analysis (2)
      WBGene00004039 Caenorhabditis elegans From_analysis (2)
      WBGene00004038 Caenorhabditis elegans From_analysis (2)
    Structured_description: Concise_description: plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras. Paper_evidence: WBPaper00003022
            WBPaper00023291
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17175)
      DOID:0080379 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17175)
      DOID:1184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17175)
      DOID:0080382 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17175)
  Molecular_info: Corresponding_CDS (12)
    Corresponding_CDS_history: F31B12.1a:wp40
      F31B12.1b:wp40
      F31B12.1b:wp52
    Corresponding_transcript (12)
    Other_sequence (49)
    Associated_feature (13)
  Experimental_info: RNAi_result (25)
    Expr_pattern (11)
    Drives_construct: WBCnstr00000769
      WBCnstr00003170
      WBCnstr00006426
      WBCnstr00018194
      WBCnstr00035730
    Construct_product: WBCnstr00006426
      WBCnstr00035730
    Microarray_results (85)
    Expression_cluster (182)
    Interaction (14)
    WBProcess: WBbiopr:00000067
  Map_info (3)
  Reference (40)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene