[Bargmann CI] defective chemotaxis to volatile odorants
[C.elegansII] n2144 : defective chemotaxis to some volatile odoratants. n2144/Df similar. NA1. [Bargmann et al. 1993]
[Dwyer ND] n2144 defective in odorant response to benzaldehyde, diacetyl, normal response to isoamyl alcohol, pyrazine. Fails to localize ODR-10 to cilia of AWA neurons. n2144 rescued by subclone including Y102E9.1, encoding 445 aa protein. n2144 is M372L plus splice acceptor change.
odr-4 encodes a novel type II membrane protein; ODR-4 is required for localization of a subset of G protein-coupled receptors (GPCRs)s, including ODR-10, to the cilia of olfactory neurons; ODR-4 affects response to a subset of AWA- and AWC- mediated olfactory responses, and is required for social feeding of npr-1 mutant animals; ODR-4 physically interacts with ODR-8 to form a complex at the endoplasmic reticulum membrane, and physically interacts wtih ODR-10, as well; ODR-4 is expressed in twelve pairs of chemosensory neurons: the ten amphid neurons and two phasmid neurons; odr-4 expression overlaps that of odr-8.
Involved in olfactory behavior; receptor localization to non-motile cilium; and response to odorant. Located in intracellular membrane-bounded organelle and protein-containing complex. Expressed in chemosensory neurons and neurons. Is an ortholog of human ODR4 (odr-4 GPCR localization factor homolog).