WormBase Tree Display for Gene: WBGene00003369

WBGene00003369 SMap: S_parent: Sequence: C36E6
  Identity: Version: 1
    Name: CGC_name: mlc-1 Person_evidence: WBPerson21
      Sequence_name: C36E6.3
      Molecular_name: C36E6.3
        C36E6.3.1
        CE34269
      Other_name: C36E6.f Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_C36E6.3 Accession_evidence: NDB BX284606
      Public_name: mlc-1
    DB_info: Database: AceView gene XS73
        WormQTL gene WBGene00003369
        WormFlux gene WBGene00003369
        NDB locus_tag CELE_C36E6.3
        Panther gene CAEEL|WormBase=WBGene00003369|UniProtKB=P19625
          family PTHR23049
        NCBI gene 181776
        RefSeq protein NM_078428.8
        SwissProt UniProtAcc P19625
        UniProt_GCRP UniProtAcc P19625
        OMIM gene 160781
            617378
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mlc
    Allele (20)
    Legacy_information: [C.elegansII] Deletions (eg sup-10(n184)) viable, normal muscle; increased lethality of mlc-2(0).Resembles mammalian non-muscle MLC; expressed in both pharynx and body wall. Not transpliced. [Cummins and Anderson 1988; TR]
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00063216 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00025039 Caenorhabditis briggsae From_analysis: OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00025038 Caenorhabditis briggsae From_analysis: OMA
            WormBase-Compara
      WBGene00063215 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00150713 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00153930 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00120705 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00133057 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00070777 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00222893 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2394 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g3249 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g3250 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13082 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g20307 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g20308 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g19901 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g19902 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g2937 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g2938 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g14036 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g14037 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g1760 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g1761 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g20596 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g20597 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g954 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g20095 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g20096 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00086.g3913 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_X.g22793 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g22794 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13577 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13578 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00648.g13985 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00648.g13986 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_11841.g40491 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01499 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_01500 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_023425 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_023426 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07367 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07368 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g15590 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0031400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      Sp34_X0031500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g21040 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00241976 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00272392 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00265783 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286939 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000006392 Saccharomyces cerevisiae From_analysis: Panther
            PhylomeDB
      FB:FBgn0002773 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-990712-15 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-991019-3 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-040912-115 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-050417-421 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-060331-137 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-120917-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:7583 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:7586 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:29824 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:21719 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:29825 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      MGI:107495 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      MGI:97272 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      MGI:97273 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      MGI:1891705 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:3141 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1308262 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1564245 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1561258 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
    Paralog: WBGene00003370 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00003372 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mlc-1 encodes a muscle regulatory myosin light chain that is nearly identical to MLC-2 and functions redundantly with MLC-2 in the body-wall and in pharyngeal muscle to affect L1 larval viability, elongation, and pharyngeal and body-wall muscle development, and also affects locomotion and growth; expressed in the body-wall muscles, pharyngeal muscles, and vulval muscles. Paper_evidence: WBPaper00001094
            WBPaper00003259
            WBPaper00006395
          Curator_confirmed: WBPerson48
          Date_last_updated: 09 Aug 2004 00:00:00
      Automated_description: Predicted to enable myosin heavy chain binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112190 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:29824)
      DOID:0110316 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7583)
      DOID:0080326 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7583)
  Molecular_info: Corresponding_CDS: C36E6.3
    Corresponding_CDS_history: C36E6.3:wp102
    Corresponding_transcript: C36E6.3.1
    Other_sequence (127)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00042074 Inferred_automatically: RNAi_primary
      WBRNAi00024757 Inferred_automatically: RNAi_primary
      WBRNAi00027213 Inferred_automatically: RNAi_primary
      WBRNAi00011705 Inferred_automatically: RNAi_primary
      WBRNAi00011703 Inferred_automatically: RNAi_primary
      WBRNAi00059498 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2736
      Expr4931
      Expr1023343
      Expr1031548
      Expr1146071
      Expr2013589
      Expr2031822
    Drives_construct (12)
    Construct_product: WBCnstr00036156
    Microarray_results (19)
    Expression_cluster (253)
    Interaction (32)
  Map_info: Map: X Position: 24.14
    Well_ordered
    Positive: Positive_clone: C36E6 Inferred_automatically: From sequence, transcript, pseudogene data
        ZK54
    Mapping_data: Multi_point: 4734
      Pos_neg_data: 5855
        5856
        5857
        5858
        5859
        5860
        5861
  Reference (41)
  Remark (3)
  Method: Gene