WormBase Tree Display for Gene: WBGene00003153

WBGene00003153 SMap: S_parent: Sequence: Y67D8C
  Identity: Version: 2
    Name: CGC_name: mca-3
      Sequence_name: Y67D8C.10
      Molecular_name (21)
      Other_name: cup-7 Person_evidence: WBPerson170
        CELE_Y67D8C.10 Accession_evidence: NDB BX284604
      Public_name: mca-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Acquires_merge: WBGene00000847
                Imported: Initial conversion from geneace
        2 09 Oct 2007 09:36:44 WBPerson2970 Name_change: Other_name: cup-7
      Acquires_merge: WBGene00000847
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mca
    Allele (491)
    Legacy_information: [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1.
    Strain: WBStrain00032351
      WBStrain00008044
      WBStrain00008045
      WBStrain00007591
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog: WBGene00065697 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026242 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00039147 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00041046 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00140346 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00191552 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00234977 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8292 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11938 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7060 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g2606 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g22208 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g301 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g17467 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g1036 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g6708 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g13277 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00025.g1547 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_11550.g23311 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_14909.g24847 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_IV.g14273 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold604.g5537 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00058.g2872 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_04777 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014332 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03115 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_40246500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g9915 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00132135 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00179990 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00073412 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00240842 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00203721 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00264108 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00266240 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000002974 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0259214 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030925-29 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040718-174 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-061016-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-080409-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-080409-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-061027-60 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:814 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:815 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:816 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:817 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:105368 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:104653 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1347353 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:88111 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2176 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621303 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621304 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621305 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (14)
    Structured_description: Concise_description: mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane. Paper_evidence: WBPaper00003407
            WBPaper00004883
            WBPaper00029172
          Curator_confirmed: WBPerson1843
          Date_last_updated: 30 Apr 2007 00:00:00
      Automated_description: Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; nematode larval development; and positive regulation of growth rate. Located in plasma membrane. Expressed in body wall musculature; coelomocyte; intestine; nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060307 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:814)
      DOID:0111829 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:816)
      DOID:0050564 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:815)
      DOID:0110467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:815)
      DOID:11714 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817)
  Molecular_info: Corresponding_CDS: Y67D8C.10a
      Y67D8C.10b
      Y67D8C.10c
      Y67D8C.10d
      Y67D8C.10e
    Corresponding_transcript (11)
    Other_sequence (125)
    Associated_feature (33)
  Experimental_info: RNAi_result: WBRNAi00103077 Inferred_automatically: RNAi_primary
      WBRNAi00009413 Inferred_automatically: RNAi_primary
      WBRNAi00110940 Inferred_automatically: RNAi_primary
      WBRNAi00057995 Inferred_automatically: RNAi_primary
      WBRNAi00026914 Inferred_automatically: RNAi_primary
      WBRNAi00103078 Inferred_automatically: RNAi_primary
      WBRNAi00103079 Inferred_automatically: RNAi_primary
      WBRNAi00066558 Inferred_automatically: RNAi_primary
      WBRNAi00021260 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8320
      Expr8321
      Expr12128
      Expr1024986
      Expr1031488
      Expr1161419
      Expr2013444
      Expr2031678
    Drives_construct: WBCnstr00008391
    Construct_product: WBCnstr00000243
      WBCnstr00000246
      WBCnstr00000247
    Microarray_results (52)
    Expression_cluster (158)
    Interaction (38)
  Map_info: Map: IV Position: -5.83327 Error: 0.101838
    Positive: Positive_clone: Y67D8
        Y67D8C Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3954
  Reference (11)
  Method: Gene