WormBase Tree Display for Gene: WBGene00003112

WBGene00003112 SMap: S_parent: Sequence: F35G12
  Identity: Version: 1
    Name: CGC_name: mab-21 Person_evidence: WBPerson261
      Sequence_name: F35G12.6
      Molecular_name: F35G12.6
        F35G12.6.1
        CE32651
      Other_name: CELE_F35G12.6 Accession_evidence: NDB BX284603
      Public_name: mab-21
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mab
    Allele (30)
    Legacy_information: [Chow KL] Transformation of thick ray 6 to a thin ray, which is anteriorly displaced and fuses with ray 4 (>95%). A tenth ray derived from hypodermal cell T.apapa is found in about 50% of the sides scored in all three alleles. mab-21(bx53)/yDf10 is embryonic lethal. Both males and hermaphrodites have slightly shorter body length (~85% of wild type)
      [C.elegansII] bx53 : transformation of thick ray 6 to a thin ray, which is anteriorly displaced and fuses with ray 4 (>95%). Tenth ray derived from T.apapa, between rays 5 and 7, is found in ~50% of sides scored. Both males and hermaphrodites have slightly shorter body length (~85% of wild type); reduced brood size; males backward Unc, reduced mating efficiency. Mosaic focus cell autonomous for R6, non-autonomous for T.apapa. Probable hypomorph, bx53/Df is embryonic lethal. OA2: bx41, sy155 (similar). Cloned: encodes predicted 386 aa novel protein. [Baird et al. 1991; Chow et al. 1995; KC; EM; PS]
    Complementation_data: [Chow KL] complements emb-1(hc57), emb-2(hc58), emb-5(hc61), emb-7(hc66), emb-8(hc69), emb-13(g6), emb-32(g58)
    Strain: WBStrain00002152
      WBStrain00030819
      WBStrain00007160
      WBStrain00007166
    RNASeq_FPKM (74)
    GO_annotation (4)
    Ortholog: WBGene00061744 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00037527 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00143144 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00135199 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00224108 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g4436 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g75 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g11950 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g21862 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g14743 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g13866 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6512 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3053 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g20523 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6680 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1274 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-mab-21 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp5_scaffold_00664.g14182 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_14938 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_010066 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03852 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g16858 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30069600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g7489 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00244454 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00203478 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00260368 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292712 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0027546 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0029003 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-011101-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-020516-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6757 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6758 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1333773 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1346022 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1595520 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1589984 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. Paper_evidence: WBPaper00002335
            WBPaper00004801
            WBPaper00013240
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in cell fate commitment; embryo development; and nematode male tail mating organ morphogenesis. Expressed in several structures, including PVC; VA2; hyp7 syncytium; ray 6; and sensory neurons. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Is an ortholog of human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111802 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6758)
      DOID:12270 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6758)
  Molecular_info: Corresponding_CDS: F35G12.6
    Corresponding_transcript: F35G12.6.1
    Other_sequence (37)
    Associated_feature: WBsf645104
      WBsf645105
      WBsf224765
  Experimental_info: RNAi_result (26)
    Expr_pattern (12)
    Drives_construct: WBCnstr00002911
      WBCnstr00004455
      WBCnstr00010357
      WBCnstr00012531
      WBCnstr00021618
      WBCnstr00036224
    Construct_product: WBCnstr00010357
      WBCnstr00021618
      WBCnstr00036224
    Microarray_results (22)
    Expression_cluster (150)
    Interaction (17)
  Map_info: Map: III Position: -3.02765 Error: 0.006765
    Well_ordered
    Positive: Positive_clone: C56A8
        F35G12 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: F10F2
        W03D1
    Mapping_data: 2_point: 4694
        4696
        6035
        6036
        6037
        6038
      Multi_point (15)
      Pos_neg_data: 4695
        6012
        6013
        6014
        6015
        6016
        6017
        6018
  Reference (55)
  Method: Gene