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WormBase Tree Display for Gene: WBGene00003020

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Name Class

WBGene00003020SMapS_parentSequenceC32F10
IdentityVersion1
NameCGC_namelin-35Person_evidenceWBPerson261
Sequence_nameC32F10.2
Molecular_nameC32F10.2
C32F10.2.1
CE24823
Other_nameCELE_C32F10.2Accession_evidenceNDBBX284601
Public_namelin-35
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlin
Allele (104)
Legacy_informationn745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)).
See also n373, n745
[C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS]
Strain (17)
Component_of_genotypeWBGenotype00000009
RNASeq_FPKM (74)
GO_annotation (50)
OrthologWBGene00066595Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00026810Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00126221Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00192330Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00222784Brugia malayiFrom_analysisWormBase-Compara
CSP21.g1346Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g2008Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g3800Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g11183Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g4008Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g15534Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g436Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g414Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g19848Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00596.g12609Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_00596.g12610Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-lin-35Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17053Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00851.g16093Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_14290Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_001005Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g06627Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g11277Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10296200Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrI_pilon.g1001Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00238574Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00278054Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00260618Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00295509Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0015799Drosophila melanogasterFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
FB:FBgn0038390Drosophila melanogasterFrom_analysisInparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-040428-1Danio rerioFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
ZFIN:ZDB-GENE-030131-8179Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-061109-2Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:9884Homo sapiensFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
HGNC:9893Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:9894Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:97874Mus musculusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
MGI:103300Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:105085Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:3540Rattus norvegicusFrom_analysisOMA
OrthoFinder
OrthoInspector
Panther
RGD:3541Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1595511Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionConcise_descriptionlin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, loss of lin-35 activity results in enhanced RNA interference; lin-35 activity is also required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.Paper_evidenceWBPaper00003329
WBPaper00004635
WBPaper00005137
WBPaper00005931
WBPaper00024215
WBPaper00024320
WBPaper00024322
WBPaper00024692
WBPaper00027135
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated05 May 2009 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1059Homo sapiensPaper_evidenceWBPaper00024322
Accession_evidenceOMIM309580
Curator_confirmedWBPerson324
Date_last_updated18 Apr 2013 00:00:00
Potential_model (16)
Disease_relevanceHuman ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development.Homo sapiensPaper_evidenceWBPaper00024322
WBPaper00024692
WBPaper00003646
Curator_confirmedWBPerson324
Date_last_updated23 Apr 2013 00:00:00
Models_disease_assertedWBDOannot00000614
WBDOannot00001021
Molecular_infoCorresponding_CDSC32F10.2
Corresponding_transcriptC32F10.2.1
Associated_featureWBsf643315
WBsf643316
WBsf656335
WBsf656336
WBsf656337
WBsf656338
WBsf983774
WBsf217712
Gene_product_binds (376)
Transcription_factorWBTranscriptionFactor000270
Experimental_infoRNAi_result (78)
Expr_patternChronogram622
Expr1291
Expr3128
Expr1015789
Expr1031411
Expr1145718
Expr2013177
Expr2031409
Drives_constructWBCnstr00004066
WBCnstr00006281
WBCnstr00011156
WBCnstr00017294
WBCnstr00036281
Construct_productWBCnstr00006281
WBCnstr00011156
WBCnstr00017287
WBCnstr00017294
WBCnstr00017295
WBCnstr00017296
WBCnstr00021077
WBCnstr00021078
WBCnstr00021079
WBCnstr00036281
Regulate_expr_cluster (16)
AntibodyWBAntibody00000200
WBAntibody00001176
WBAntibody00003008
WBAntibody00003009
Microarray_results (20)
Expression_cluster (156)
Interaction (322)
Product_binds_matrixWBPmat00005534
WBPmat00005535
WBPmat00005536
WBPmat00005540
WBPmat00005541
WBPmat00005542
WBPmat00005543
WBPmat00005544
WBPmat00005545
Map_infoMapIPosition0.461719Error0.000997
Well_ordered
PositivePositive_cloneC32F10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point (4)
Reference (253)
PictureWBPicture0000013091
MethodGene