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WormBase Tree Display for Gene: WBGene00002245

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Name Class

WBGene00002245SMapS_parentSequenceCHROMOSOME_IV
IdentityVersion1
NameCGC_namelag-1Person_evidenceWBPerson320
Sequence_nameK08B4.1
Molecular_name (12)
Other_nameCELE_K08B4.1Accession_evidenceNDBBX284604
Public_namelag-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlag
Allele (226)
Possibly_affected_byWBVar02153178
WBVar02157780
Legacy_information (2)
StrainWBStrain00022545
WBStrain00022552
WBStrain00034581
WBStrain00007146
WBStrain00030024
WBStrain00051949
WBStrain00052019
WBStrain00051599
WBStrain00051810
WBStrain00054794
RNASeq_FPKM (74)
GO_annotation (59)
OrthologWBGene00066071Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00027957Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00074452Caenorhabditis remaneiFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00162533Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00139190Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00159693Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00106266Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00124537Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00157120Caenorhabditis brenneriFrom_analysisTreeFam
WormBase-Compara
WBGene00163187Caenorhabditis brenneriFrom_analysisTreeFam
WormBase-Compara
WBGene00146956Caenorhabditis brenneriFrom_analysisTreeFam
WormBase-Compara
WBGene00153249Caenorhabditis brenneriFrom_analysisTreeFam
WormBase-Compara
WBGene00225158Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g11625Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g3463Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g2538Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g21101Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g10437Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g21513Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g10223Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g4816Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g16497Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g176Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g10681Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g1126Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g1128Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-lag-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g15211Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17341Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00045.g2401Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_00133.g5225Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_00372.g10324Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_01943.g23995Caenorhabditis sinicaFrom_analysisWormBase-Compara
GCK72_013643Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g03356Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g1517Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g17273Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g17274Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g17275Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g17276Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g6544Panagrellus redivivusFrom_analysisWormBase-Compara
Pan_g8922Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_40160700Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIV_pilon.g10552Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00242124Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00106264Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00256829Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00265847Strongyloides rattiFrom_analysisWormBase-Compara
FB:FBgn0004837Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-031117-1Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-050307-4Danio rerioFrom_analysisEnsEMBL-Compara
OrthoInspector
Panther
ZFIN:ZDB-GENE-070319-1Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:5724Homo sapiensFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:13761Homo sapiensFrom_analysisEnsEMBL-Compara
OrthoInspector
Panther
MGI:96522Mus musculusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:1196616Mus musculusFrom_analysisEnsEMBL-Compara
OrthoInspector
Panther
RGD:1310557Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:1304786Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoInspector
Panther
RGD:1593096Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
Structured_descriptionConcise_descriptionlag-1 encodes a transcription factor orthologous to members of the CSL (CBF1, Suppressor of Hairless, LAG-1) family that is highly conserved amongst metazoans; during development, LAG-1 functions as a downstream effector in both the lin-12- and glp-1-mediated Notch-like signaling pathways and accordingly, is required for such processes as germline induction, AC/VU lateral signaling, and embryonic development; LAG-1 can bind a consensus CSL family binding site found in multiple copies in the predicted regulatory regions of lin-12, glp-1, and lag-1, thus implicating LAG-1 as an important component of the positive feedback loop observed in the LIN-12/GLP-1 signaling pathway.Paper_evidenceWBPaper00001423
WBPaper00002452
WBPaper00004120
WBPaper00004589
Curator_confirmedWBPerson1843
Date_last_updated05 Jun 2006 00:00:00
Automated_descriptionEnables Notch binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cell differentiation; dauer exit; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Expressed in several structures, including P4.p; P5.p; P6.p; P7.p; and P8.p. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is an ortholog of human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (2)
Molecular_infoCorresponding_CDSK08B4.1a
K08B4.1b
K08B4.1c
K08B4.1d
Corresponding_transcriptK08B4.1a.1
K08B4.1b.1
K08B4.1c.1
K08B4.1d.1
Other_sequence (53)
Associated_feature (33)
Gene_product_binds (26)
Transcription_factorWBTranscriptionFactor000101
Experimental_info (11)
Map_infoMapIVPosition2.97979Error0.005015
Well_ordered
PositivePositive_cloneF43A12
K08B4Inferred_automaticallyFrom sequence, transcript, pseudogene data
M02G2
NegativeNegative_cloneM03D4
Mapping_dataMulti_point2827
2828
3371
3372
3373
3374
4900
Reference (143)
Remarkdata extracted from Lambie & Kimble 1991
Datum extracted from Christensen et al. (1996)
M03D4.3 has been fused with K08B4.1, latter is lag-1 in sequence annotation. [sdm 05/00]
MethodGene