WormBase Tree Display for Gene: WBGene00002004

WBGene00002004 Evidence: Paper_evidence: WBPaper00005342
  SMap: S_parent: Sequence: Y53C10A
  Identity: Version: 1
    Name: CGC_name: hsf-1 Person_evidence: WBPerson1157
      Sequence_name: Y53C10A.12
      Molecular_name: Y53C10A.12
        Y53C10A.12.1
        CE22380
        Y53C10A.12.2
      Other_name: CELE_Y53C10A.12 Accession_evidence: NDB BX284601
      Public_name: hsf-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsf
    Allele (276)
    Possibly_affected_by: WBVar02153033
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (91)
    Ortholog: WBGene00055962 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00038076 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00160306 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00129007 Caenorhabditis japonica From_analysis: Inparanoid_8
      WBGene00227007 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10422 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g2094 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13210 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP31.g26098 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4505 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g5867 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g10277 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g23314 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-hsf-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_III.g11488 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g11812 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_02805.g27976 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_14925 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001604 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05970 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g4930 Panagrellus redivivus From_analysis: WormBase-Compara
      chrI_pilon.g2374 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00238233 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00272833 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256897 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00296340 Trichuris muris From_analysis: WormBase-Compara
      WBGene00300191 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003041 Saccharomyces cerevisiae From_analysis: OrthoFinder
            OrthoInspector
            Panther
      FB:FBgn0001222 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000616-16 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-011128-1 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-050306-18 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-091204-174 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:5224 Homo sapiens From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:5225 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:5227 Homo sapiens From_analysis: OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:96238 Mus musculus From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:96239 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1347058 Mus musculus From_analysis: OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:68395 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620913 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310808 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description (2)
  Disease_info: Potential_model: DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5224)
      DOID:0110255 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5227)
      DOID:83 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5227)
    Disease_relevance: C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. Homo sapiens Paper_evidence: WBPaper00041564
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2013 00:00:00
  Molecular_info: Corresponding_CDS: Y53C10A.12
    Corresponding_transcript: Y53C10A.12.1
      Y53C10A.12.2
    Other_sequence (32)
    Associated_feature: WBsf665013
      WBsf717585
      WBsf978924
      WBsf985423
      WBsf220382
    Gene_product_binds: WBsf919560
      WBsf919561
      WBsf919565
      WBsf919566
      WBsf919567
      WBsf919568
      WBsf919569
      WBsf919570
      WBsf919571
    Transcription_factor: WBTranscriptionFactor000178
  Experimental_info (11)
  Map_info: Map: I Position: 13.0131 Error: 0.000976
    Positive: Positive_clone: Y53C10A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4416
        5648
  Reference (373)
  Method: Gene