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WormBase Tree Display for Gene: WBGene00001680

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Name Class

WBGene00001680SMapS_parentSequenceF52A8
IdentityVersion2
NameCGC_namegpb-2Person_evidenceWBPerson625
Sequence_nameF52A8.2
Molecular_nameF52A8.2a
F52A8.2a.1
CE50400
F52A8.2b
Other_nameeat-11
gbp-2Paper_evidenceWBPaper00033094
CELE_F52A8.2Accession_evidenceNDBBX284601
Public_namegpb-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
215 Dec 2010 15:28:40WBPerson2970EventAcquires_mergeWBGene00001524
Name_changeOther_namegbp-2
Acquires_mergeWBGene00001524
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgpb
Allele (47)
Legacy_information[Leon Avery] Weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline: will not grown at concentrations >= 1 mM.
See also ad541
[C.elegansII] ad541 : weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline (cholinergic agonist): will not grown at concentrations >= 1 mM. Synthetic lethal with eat-6; suppressed by egl-30(gf), exp-2(gf). NA1. [Avery 1993; DA; JT]
[M Robatzek] eat-11 is allelic to gpb-2 (Robatzek et al. Current Biology 2001, 11:288-293)
StrainWBStrain00028988
WBStrain00029004
WBStrain00022804
WBStrain00028986
WBStrain00037676
WBStrain00005480
WBStrain00005517
RNASeq_FPKM (74)
GO_annotation (20)
OrthologWBGene00067672Caenorhabditis remaneiFrom_analysis (4)
WBGene00032939Caenorhabditis briggsaeFrom_analysis (4)
WBGene00158878Caenorhabditis brenneriFrom_analysis (4)
WBGene00153438Caenorhabditis brenneriFrom_analysis (4)
WBGene00100651Pristionchus pacificusFrom_analysis (3)
WBGene00218149Caenorhabditis japonicaFrom_analysis (2)
WBGene00128553Caenorhabditis japonicaFrom_analysis (2)
WBGene00033109Caenorhabditis briggsaeFrom_analysisWormBase-Compara
WBGene00224500Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g9256Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g4576Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g16738Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g8592Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g10802Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g22261Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g9867Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g10636Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g4898Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g16769Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_01288.g16172Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-gpb-2Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17292Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00506.g12235Caenorhabditis sinicaFrom_analysisWormBase-Compara
GCK72_000141Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g10648Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g4107Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10089600Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrI_pilon.g1368Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00243597Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00243598Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00262876Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00292982Trichuris murisFrom_analysisWormBase-Compara
SGD:S000005738Saccharomyces cerevisiaeFrom_analysis (8)
FB:FBgn0030011Drosophila melanogasterFrom_analysis (9)
ZFIN:ZDB-GENE-040426-1712Danio rerioFrom_analysis (9)
ZFIN:ZDB-GENE-070112-342Danio rerioFrom_analysis (9)
HGNC:4401Homo sapiensFrom_analysis (9)
MGI:101848Mus musculusFrom_analysis (9)
RGD:620759Rattus norvegicusFrom_analysis (9)
ParalogWBGene00001679Caenorhabditis elegansFrom_analysis (2)
Structured_descriptionConcise_descriptiongpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10.Paper_evidenceWBPaper00002466
WBPaper00004406
WBPaper00004687
WBPaper00004713
WBPaper00004714
WBPaper00014715
WBPaper00015075
WBPaper00015719
WBPaper00016788
Curator_confirmedWBPerson48
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable signaling receptor complex adaptor activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of egg-laying behavior; and regulation of pharyngeal pumping. Located in neuronal cell body. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Is an ortholog of human GNB5 (G protein subunit beta 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0081008Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4401)
Molecular_infoCorresponding_CDSF52A8.2a
Corresponding_CDS_historyF52A8.2:wp246
Corresponding_transcriptF52A8.2b
F52A8.2a.1
Other_sequence (82)
Associated_featureWBsf984145
WBsf984146
WBsf1010061
WBsf1010062
WBsf219742
WBsf219743
WBsf219744
Experimental_infoRNAi_resultWBRNAi00047906Inferred_automaticallyRNAi_primary
WBRNAi00089830Inferred_automaticallyRNAi_primary
WBRNAi00032572Inferred_automaticallyRNAi_primary
WBRNAi00116830Inferred_automaticallyRNAi_primary
WBRNAi00063514Inferred_automaticallyRNAi_primary
WBRNAi00090194Inferred_automaticallyRNAi_primary
WBRNAi00089876Inferred_automaticallyRNAi_primary
WBRNAi00090035Inferred_automaticallyRNAi_primary
Expr_patternExpr1344
Expr1360
Expr1020669
Expr1031001
Expr1151735
Expr2012200
Expr2030436
Drives_constructWBCnstr00000572
WBCnstr00001696
WBCnstr00001704
WBCnstr00022812
WBCnstr00036776
Construct_productWBCnstr00001696
WBCnstr00036776
AntibodyWBAntibody00000370
Microarray_results (19)
Expression_cluster (149)
Interaction (64)
Map_infoMapIPosition1.91015Error0.005018
Well_ordered
PositivePositive_cloneF52A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
R02H7
NegativeNegative_cloneF07A5
Mapping_data2_point6193
Multi_point2456
2457
2458
2459
2460
3034
3946
3947
4489
4710
Pos_neg_data7086
7087
7088
Reference (70)
RemarkInteracting_genes '[Leon Avery] eat-6: Lethal or subviable in double mutants with eat-6.
Interacting_genes '[Leon Avery] egl-30: Suppressed by egl-30(gf) mutations.
MethodGene