WormBase Tree Display for Gene: WBGene00000055
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| WBGene00000055 | SMap | S_parent | Sequence | F25G6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | acr-16 | Person_evidence | WBPerson1430 | |||||
| Sequence_name | F25G6.3 | ||||||||
| Molecular_name | F25G6.3 | ||||||||
| F25G6.3.1 | |||||||||
| CE09639 | |||||||||
| Other_name | Ce21 | ||||||||
| CELE_F25G6.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | acr-16 | ||||||||
| DB_info | Database | AceView | gene | 5J43 | |||||
| WormQTL | gene | WBGene00000055 | |||||||
| WormFlux | gene | WBGene00000055 | |||||||
| NDB | locus_tag | CELE_F25G6.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000055|UniProtKB=P48180 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 179235 | |||||||
| RefSeq | protein | NM_072806.5 | |||||||
| SwissProt | UniProtAcc | P48180 | |||||||
| UniProt_GCRP | UniProtAcc | P48180 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | acr | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00031630 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog | WBGene00053117 | Caenorhabditis remanei | From_analysis | OMA | |||||
| TreeFam | |||||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00024720 | Caenorhabditis briggsae | From_analysis | Hillier-set | ||||||
| OrthoMCL | |||||||||
| OMA | |||||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00155698 | Caenorhabditis brenneri | From_analysis | OMA | ||||||
| TreeFam | |||||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00127824 | Caenorhabditis japonica | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00192223 | Caenorhabditis brenneri | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00233847 | Brugia malayi | From_analysis | WormBase-Compara | ||||||
| CBOVI.g589 | Caenorhabditis bovis | From_analysis | WormBase-Compara | ||||||
| CSP21.g12030 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara | ||||||
| CSP26.g2167 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara | ||||||
| CSP28.g2077 | Caenorhabditis panamensis | From_analysis | WormBase-Compara | ||||||
| CSP29.g9882 | Caenorhabditis becei | From_analysis | WormBase-Compara | ||||||
| CSP31.g3520 | Caenorhabditis uteleia | From_analysis | WormBase-Compara | ||||||
| CSP32.g7248 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara | ||||||
| CSP38.g18219 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara | ||||||
| CSP39.g25301 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara | ||||||
| CSP39.g27871 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara | ||||||
| CSP39.g7791 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara | ||||||
| CSP40.g2820 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara | ||||||
| Cang_2012_03_13_00610.g12759 | Caenorhabditis angaria | From_analysis | WormBase-Compara | ||||||
| Cni-acr-16 | Caenorhabditis nigoni | From_analysis | WormBase-Compara | ||||||
| Csp11.Scaffold613.g5951 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara | ||||||
| Csp5_scaffold_01451.g21002 | Caenorhabditis sinica | From_analysis | WormBase-Compara | ||||||
| FL83_17005 | Caenorhabditis latens | From_analysis | WormBase-Compara | ||||||
| GCK72_018879 | Caenorhabditis remanei | From_analysis | WormBase-Compara | ||||||
| OTIPU.nOt.2.0.1.g05354 | Oscheius tipulae | From_analysis | WormBase-Compara | ||||||
| Pan_g20410 | Panagrellus redivivus | From_analysis | WormBase-Compara | ||||||
| Sp34_50116010 | Caenorhabditis inopinata | From_analysis | WormBase-Compara | ||||||
| chrV_pilon.g15018 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00208954 | Caenorhabditis japonica | From_analysis | WormBase-Compara | ||||||
| WBGene00248811 | Onchocerca volvulus | From_analysis | WormBase-Compara | ||||||
| WBGene00272915 | Pristionchus pacificus | From_analysis | WormBase-Compara | ||||||
| WBGene00257040 | Strongyloides ratti | From_analysis | WormBase-Compara | ||||||
| FB:FBgn0086778 | Drosophila melanogaster | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| FB:FBgn0032151 | Drosophila melanogaster | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| FB:FBgn0028875 | Drosophila melanogaster | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040108-3 | Danio rerio | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-060503-606 | Danio rerio | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-090313-161 | Danio rerio | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| HGNC:1960 | Homo sapiens | From_analysis | Hieranoid | ||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| HGNC:15781 | Homo sapiens | From_analysis | Hieranoid | ||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| MGI:99779 | Mus musculus | From_analysis | Hieranoid | ||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| RGD:2348 | Rattus norvegicus | From_analysis | Hieranoid | ||||||
| OMA | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| Panther | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that is required for the major fast cholinergic excitatory current at C. elegans neuromuscular junctions; when expressed in Xenopus ooctyes, ACR-16 is active as a homomeric receptor and responds robustly to acetylcholine; an ACR-16::GFP reporter fusion expressed in muscle cells localizes to the tips of muscle arms, specific regions of the muscle cell membrane that form synapses with neuronal processes; acr-16::gfp promoter fusions also reveal expression in a subset of neurons; ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity, is regulated by a Wnt signaling pathway that includes CWN-2, LIN-17, CAM-1, and DSH-1. | Paper_evidence | WBPaper00003425 | |||||
| WBPaper00004459 | |||||||||
| WBPaper00005427 | |||||||||
| WBPaper00005594 | |||||||||
| WBPaper00025245 | |||||||||
| WBPaper00040939 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Apr 2012 00:00:00 | ||||||||
| Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic ion transmembrane transport. Located in cell projection. Expressed in body wall musculature; linker cell; muscle cell; and neurons. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00028761 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 May 2019 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | |||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:7474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1960) | ||||||
| Models_disease_asserted | WBDOannot00000676 | ||||||||
| Molecular_info (5) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00004901 | ||||||||
| WBCnstr00004902 | |||||||||
| WBCnstr00004903 | |||||||||
| WBCnstr00004904 | |||||||||
| WBCnstr00004905 | |||||||||
| WBCnstr00009872 | |||||||||
| WBCnstr00011440 | |||||||||
| WBCnstr00011957 | |||||||||
| WBCnstr00017746 | |||||||||
| WBCnstr00018183 | |||||||||
| Construct_product | WBCnstr00001360 | ||||||||
| WBCnstr00006788 | |||||||||
| WBCnstr00009355 | |||||||||
| WBCnstr00011441 | |||||||||
| WBCnstr00014504 | |||||||||
| WBCnstr00020316 | |||||||||
| Antibody | WBAntibody00001986 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction (28) | |||||||||
| Map_info | Map | V | Position | 1.46223 | Error | 0.003864 | |||
| Positive | Positive_clone | F25G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4869 | |||||||
| 5605 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (89) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
