WormBase Tree Display for Gene: WBGene00000099

WBGene00000099 SMap: S_parent: Sequence: B0207
  Identity: Version: 1
    Name: CGC_name: air-2 Person_evidence: WBPerson205
      Sequence_name: B0207.4
      Molecular_name: B0207.4
        B0207.4.1
        CE24761
        B0207.4.2
      Other_name: let-603
        stu-7
        cyk-6
        CELE_B0207.4 Accession_evidence: NDB BX284601
      Public_name: air-2
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: air
    Allele (19)
    Legacy_information: [Hodgkin JA] e2631 hermaphrodites are long, uncoordinated and sterile, usually with a conspicuous constriction in the mid-region of the body. Males grow poorly, male tail very abnormal, ME0.
      [McDowall JS] Sterile adult
      [C.elegansII] h289 : sterile adult (gonad tumorous mass). OA3: h408, h437, h812 (sterile adults). Cloned: partial cosmid rescue (C32E7); rescued to Mel. [KR]
      [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis defects
    Strain: WBStrain00023752
      WBStrain00035642
      WBStrain00004633
      WBStrain00007296
      WBStrain00007300
      WBStrain00034749
      WBStrain00051600
      WBStrain00051601
    RNASeq_FPKM (74)
    GO_annotation (65)
    Ortholog: WBGene00066584 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026778 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00153601 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00176308 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00128903 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00193267 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00221969 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12058 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g7587 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3121 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g2039 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3765 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g11150 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g22561 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g535 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g21074 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g18609 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g17012 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00204.g6948 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-air-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17083 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01534.g21540 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_14281 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001016 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04668 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14184 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g17746 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g4707 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10293700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1026 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00248014 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00111246 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00259111 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000006130 Saccharomyces cerevisiae From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0024227 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040801-161 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020419-40 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11393 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11391 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11390 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1321119 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
      MGI:107168 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:894678 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621625 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:628895 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1309573 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00000098 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 i modified in vitro by the GEI-17 E3 SUMO ligase; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. Paper_evidence (12)
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson363
            WBPerson567
          Date_last_updated: 10 Jun 2015 00:00:00
      Automated_description: Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human AURKB (aurora kinase B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:3008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:0070183 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11391)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:8634 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393)
      DOID:2152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
      DOID:363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11393)
  Molecular_info: Corresponding_CDS: B0207.4
    Corresponding_transcript: B0207.4.1
      B0207.4.2
    Other_sequence (54)
    Associated_feature: WBsf217728
      WBsf217729
  Experimental_info: RNAi_result (63)
    Expr_pattern (11)
    Drives_construct: WBCnstr00037734
    Construct_product: WBCnstr00000897
      WBCnstr00005318
      WBCnstr00005560
      WBCnstr00014917
      WBCnstr00017655
      WBCnstr00021506
      WBCnstr00037734
    Antibody: WBAntibody00000198
      WBAntibody00000511
      WBAntibody00001492
      WBAntibody00002053
      WBAntibody00002354
      WBAntibody00002454
      WBAntibody00002607
      WBAntibody00002722
      WBAntibody00002782
    Microarray_results (21)
    Expression_cluster (167)
    Interaction (256)
  Map_info: Map: I Position: 0.482005 Error: 0.002155
    Well_ordered
    Positive: Positive_clone: B0207 Inferred_automatically: From sequence, transcript, pseudogene data
        C32E7
    Negative: Outside_rearr: hDf29
      Negative_clone: C03E6
        C04F1
        C07F10
        C30B6
        C53A11
    Mapping_data: 2_point: 5225
        5226
      Multi_point: 3520
        3865
        4380
        4601
      Pos_neg_data (12)
  Reference: WBPaper00002829
    WBPaper00003320
    WBPaper00003325
    WBPaper00003548
    WBPaper00003985
    WBPaper00004268
    WBPaper00004303
    WBPaper00004349
    WBPaper00004389
    WBPaper00004455
    WBPaper00004539
    WBPaper00004544
    WBPaper00005165
    WBPaper00005173
    WBPaper00005198
    WBPaper00005264
    WBPaper00005311
    WBPaper00005390
    WBPaper00005453
    WBPaper00005639
    WBPaper00005669
    WBPaper00005872
    WBPaper00006112
    WBPaper00006181
    WBPaper00010570
    WBPaper00010572
    WBPaper00010655
    WBPaper00011746
    WBPaper00012305
    WBPaper00016978
    WBPaper00017100
    WBPaper00017723
    WBPaper00017838
    WBPaper00017875
    WBPaper00017877
    WBPaper00018058
    WBPaper00018065
    WBPaper00018364
    WBPaper00018625
    WBPaper00018630
    WBPaper00018720
    WBPaper00023620
    WBPaper00024014
    WBPaper00024115
    WBPaper00024200
    WBPaper00024319
    WBPaper00024321
    WBPaper00024605
    WBPaper00025028
    WBPaper00025124
    WBPaper00025213
    WBPaper00025253
    WBPaper00025590
    WBPaper00025783
    WBPaper00026599
    WBPaper00026922
    WBPaper00026943
    WBPaper00027048
    WBPaper00027223
    WBPaper00027235
    WBPaper00027258
    WBPaper00027919
    WBPaper00028547
    WBPaper00028715
    WBPaper00029322
    WBPaper00031316
    WBPaper00031591
    WBPaper00032264
    WBPaper00032269
    WBPaper00032405
    WBPaper00036019
    WBPaper00036964
    WBPaper00036977
    WBPaper00037054
    WBPaper00038290
    WBPaper00038491
    WBPaper00038639
    WBPaper00038682
    WBPaper00038685
    WBPaper00038695
    WBPaper00038719
    WBPaper00039264
    WBPaper00039275
    WBPaper00040358
    WBPaper00040589
    WBPaper00040620
    WBPaper00041236
    WBPaper00041481
    WBPaper00042416
    WBPaper00042737
    WBPaper00042784
    WBPaper00042793
    WBPaper00043779
    WBPaper00044445
    WBPaper00046087
    WBPaper00046470
    WBPaper00047065
    WBPaper00047300
    WBPaper00047312
    WBPaper00047420
    WBPaper00051832
    WBPaper00052316
    WBPaper00053990
    WBPaper00055090
    WBPaper00057802
    WBPaper00059375
    WBPaper00059395
    WBPaper00059491
    WBPaper00059919
    WBPaper00060187
    WBPaper00060897
    WBPaper00061317
    WBPaper00061329
    WBPaper00061356
    WBPaper00061423
    WBPaper00063050
    WBPaper00063124
    WBPaper00063125
    WBPaper00065023
    WBPaper00065308
  Remark: [McDowall JS] Extrachromosomal array containing single cosmid generated, then manipulated genetically. Partial rescue: normally sterile adult with tumorous mass, develops to tumorless egg-laying adult, eggs do not develop or hatch.
    testing swap around with sup-40, from 0.435 to 0.575
    same as cyk-6 according to cgc4544 and email 114.
    same as air-2 according to cgc4544 and email 114.
    old_name cyk-6 becomes new_name air-2 from [Woollard A, Hodgkin JA, Schumacher J].
    old_names let-603 and stu-7 had previously been identitifed with air-2.
  Method: Gene