WormBase Tree Display for Gene: WBGene00017699
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WBGene00017699 | SMap | S_parent | Sequence | F22D3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | flcn-1 | Person_evidence | WBPerson15935 | |||||
Sequence_name | F22D3.2 | ||||||||
Molecular_name (21) | |||||||||
Other_name | CELE_F22D3.2 | Accession_evidence | NDB | BX284602 | |||||
Public_name | flcn-1 | ||||||||
DB_info | Database | AceView | gene | 2H237 | |||||
WormQTL | gene | WBGene00017699 | |||||||
WormFlux | gene | WBGene00017699 | |||||||
OMIM | disease | 135150 | |||||||
gene | 607273 | ||||||||
NDB | locus_tag | CELE_F22D3.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00017699|UniProtKB=H2KY80 | |||||||
family | PTHR31441 | ||||||||
NCBI | gene | 174134 | |||||||
RefSeq | protein | NM_001306549.4 | |||||||
NM_001330952.3 | |||||||||
NM_001276732.2 | |||||||||
NM_001381469.1 | |||||||||
NM_001306551.3 | |||||||||
NM_001381470.1 | |||||||||
NM_001026937.5 | |||||||||
TrEMBL | UniProtAcc | S6FCY3 | |||||||
S6EZM3 | |||||||||
K0M7B5 | |||||||||
J7S130 | |||||||||
S6F533 | |||||||||
Q5DX40 | |||||||||
S6FMZ4 | |||||||||
UniProt_GCRP | UniProtAcc | S6FMZ4 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 29 Jun 2012 17:03:10 | WBPerson2970 | Name_change | CGC_name | flcn-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | flcn | ||||||||
Allele (252) | |||||||||
Strain | WBStrain00031743 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (20) | |||||||||
Ortholog (40) | |||||||||
Structured_description | Concise_description | F22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated inBirt-Hogg-Dube syndrome). | Paper_evidence | WBPaper00028837 | |||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 11 Dec 2006 00:00:00 | ||||||||
Automated_description | Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Expressed in excretory cell; nervous system; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in several diseases, including Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Is an ortholog of human FLCN (folliculin). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:0050676 | Homo sapiens | Paper_evidence | WBPaper00048631 | ||||
Accession_evidence | OMIM | 135150 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 03 Nov 2015 00:00:00 | ||||||||
Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | |||||
DOID:0080218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||||
DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||||
DOID:0050676 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:27310) | ||||||
Models_disease_in_annotation | WBDOannot00000382 | ||||||||
Molecular_info | Corresponding_CDS | F22D3.2c | |||||||
F22D3.2d | |||||||||
F22D3.2e | |||||||||
F22D3.2f | |||||||||
F22D3.2g | |||||||||
F22D3.2i | |||||||||
F22D3.2j | |||||||||
Corresponding_CDS_history | F22D3.2:wp127 | ||||||||
F22D3.2a:wp206 | |||||||||
F22D3.2a:wp238 | |||||||||
F22D3.2a:wp274 | |||||||||
F22D3.2b:wp206 | |||||||||
F22D3.2b:wp238 | |||||||||
F22D3.2h:wp274 | |||||||||
Corresponding_transcript | F22D3.2c.1 | ||||||||
F22D3.2d.1 | |||||||||
F22D3.2e.1 | |||||||||
F22D3.2f.1 | |||||||||
F22D3.2g.1 | |||||||||
F22D3.2i.1 | |||||||||
F22D3.2j.1 | |||||||||
Other_sequence (21) | |||||||||
Associated_feature (63) | |||||||||
Experimental_info | RNAi_result | WBRNAi00013748 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00045306 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00013747 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00031265 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092437 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092428 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (7) | |||||||||
Drives_construct | WBCnstr00017598 | ||||||||
WBCnstr00017614 | |||||||||
WBCnstr00027093 | |||||||||
Construct_product | WBCnstr00017614 | ||||||||
WBCnstr00027093 | |||||||||
WBCnstr00040219 | |||||||||
Regulate_expr_cluster | WBPaper00042236:flcn-1(ok975)_upregulated | ||||||||
WBPaper00056471:flcn-1(ok975)_downregulated | |||||||||
WBPaper00056471:flcn-1(ok975)_upregulated | |||||||||
Antibody | WBAntibody00002522 | ||||||||
Microarray_results | SMD_F22D3.2 | ||||||||
SMD_F22D3.3 | |||||||||
174160_at | |||||||||
175044_at | |||||||||
181759_at | |||||||||
A_12_P106934 | |||||||||
A_12_P150305 | |||||||||
A_12_P175042 | |||||||||
A_12_P175043 | |||||||||
Aff_F22D3.2 | |||||||||
Aff_F22D3.3 | |||||||||
GPL13394_WBGene00017699 | |||||||||
GPL13914_F22D3.2 | |||||||||
GPL14144_F22D3.2a_1512-1571_0.917_11_A | |||||||||
GPL14144_F22D3.2a_1644-1703_0.902_18_B | |||||||||
GPL14144_F22D3.2a_2148-2207_0.971_1_C | |||||||||
GPL19516_CGZ0011294 | |||||||||
GPL19516_CGZ0017492 | |||||||||
GPL19516_CGZ0017493 | |||||||||
GPL19516_CGZ0017494 | |||||||||
GPL19516_CGZ0017495 | |||||||||
GPL19516_CGZ0017496 | |||||||||
GPL19516_CGZ0017497 | |||||||||
GPL19516_CGZ0017498 | |||||||||
GPL21109_Cat_F22D3.2a | |||||||||
GPL21109_F22D3.2a | |||||||||
GPL21109_F22D3.2f | |||||||||
GPL3518_CE27138 | |||||||||
GPL8304_CE_WBGene00017699_A | |||||||||
GPL8304_CE_WBGene00017699_B | |||||||||
GPL8673_F22D3_2aP01202 | |||||||||
GPL8673_F22D3_2aP01208 | |||||||||
GPL8673_F22D3_2aP01225 | |||||||||
GPL8673_F22D3_2bP00516 | |||||||||
GPL8673_F22D3_2bP01070 | |||||||||
GPL8673_F22D3_2bP01669 | |||||||||
GPL8673_F22D3_2cP00167 | |||||||||
GPL8673_F22D3_2cP00426 | |||||||||
GPL8673_F22D3_2cP00658 | |||||||||
GPL9450_F22D3.2 | |||||||||
cea2.p.37453 | |||||||||
Expression_cluster (164) | |||||||||
Interaction | WBInteraction000402369 | ||||||||
WBInteraction000520210 | |||||||||
WBInteraction000520211 | |||||||||
WBInteraction000520212 | |||||||||
WBInteraction000520213 | |||||||||
WBInteraction000520218 | |||||||||
WBInteraction000521811 | |||||||||
WBInteraction000534849 | |||||||||
Map_info (3) | |||||||||
Reference | WBPaper00038491 | ||||||||
WBPaper00042236 | |||||||||
WBPaper00043118 | |||||||||
WBPaper00048129 | |||||||||
WBPaper00048631 | |||||||||
WBPaper00049821 | |||||||||
WBPaper00051847 | |||||||||
WBPaper00055071 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00061202 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |