WormBase Tree Display for Gene: WBGene00012550
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WBGene00012550 | SMap | S_parent | Sequence | Y37D8A | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | spcs-2 | |||||
Sequence_name | Y37D8A.10 | ||||||
Molecular_name | Y37D8A.10 | ||||||
Y37D8A.10.1 | |||||||
CE20214 | |||||||
Other_name | hpo-21 | ||||||
CELE_Y37D8A.10 | Accession_evidence | NDB | BX284603 | ||||
Public_name | spcs-2 | ||||||
DB_info | Database | AceView | gene | 3N965 | |||
WormQTL | gene | WBGene00012550 | |||||
WormFlux | gene | WBGene00012550 | |||||
NDB | locus_tag | CELE_Y37D8A.10 | |||||
Panther | gene | CAEEL|WormBase=WBGene00012550|UniProtKB=Q9XWW1 | |||||
family | PTHR13085 | ||||||
NCBI | gene | 176703 | |||||
RefSeq | protein | NM_067275.8 | |||||
SwissProt | UniProtAcc | Q9XWW1 | |||||
TREEFAM | TREEFAM_ID | TF314545 | |||||
UniProt_GCRP | UniProtAcc | Q9XWW1 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | spcs | ||||||
Allele (17) | |||||||
Strain | WBStrain00037795 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (11) | |||||||
Ortholog (35) | |||||||
Structured_description | Automated_description | Involved in IRE1-mediated unfolded protein response. Located in sarcoplasmic reticulum. Used to study Parkinson's disease. Is an ortholog of human SPCS2 (signal peptidase complex subunit 2). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 20 Nov 2013 00:00:00 | ||||||
Disease_relevance | In elegans, hpo-21, orthologous to human SPCS1, is involved with several other hpo genes in the protective response against pore-forming toxins; hpo-21 has been shown to have a protective effect in an elegans model for alpha-synuclein (alpha-syn) toxicity (implicated in Parkinson''s disease, and other alpha-synucleinopathies); this model consists of overexpression of human alpha-syn fused to green fluorescent protein (GFP) in body wall muscle cells, resulting in age-dependent alpha-syn misfolding in the cytoplasm; co-expression of a chaperone, TOR-2, in this system reduces alpha-syn-GFP misfolding, providing a genetic background in which the enhancement of alpha-syn misfolding is easily visualized; hpo-21 was identified as a interactor of catp-6/ATP13A2; deficiency of catp-6/ATP13A2 and its interactors, including hpo-21, exacerbates alpha-syn misfolding in the above elegans model. | Homo sapiens | Paper_evidence | WBPaper00038231 | |||
WBPaper00041253 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 20 Nov 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000252 | ||||||
Molecular_info | Corresponding_CDS | Y37D8A.10 | |||||
Corresponding_transcript | Y37D8A.10.1 | ||||||
Other_sequence (49) | |||||||
Associated_feature | WBsf645677 | ||||||
WBsf225936 | |||||||
WBsf225937 | |||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern | Expr9419 | ||||||
Expr1014401 | |||||||
Expr1035553 | |||||||
Expr1159394 | |||||||
Expr2012563 | |||||||
Expr2030800 | |||||||
Drives_construct | WBCnstr00029908 | ||||||
Construct_product | WBCnstr00013984 | ||||||
WBCnstr00029908 | |||||||
Microarray_results | SMD_Y37D8A.10 | ||||||
184229_at | |||||||
A_12_P114279 | |||||||
Aff_Y37D8A.10 | |||||||
GPL13394_WBGene00012550 | |||||||
GPL13914_Y37D8A.10 | |||||||
GPL14144_Y37D8A.10_246-305_0.929_10_C | |||||||
GPL14144_Y37D8A.10_331-390_0.941_8_B | |||||||
GPL14144_Y37D8A.10_381-440_0.958_1_A | |||||||
GPL19516_CGZ0044322 | |||||||
GPL21109_Y37D8A.10 | |||||||
GPL3518_CE20214 | |||||||
GPL8304_CE_WBGene00012550_A | |||||||
GPL8304_CE_WBGene00012550_B | |||||||
GPL8304_CE_WBGene00012550_C | |||||||
GPL8673_Y37D8A_10P00139 | |||||||
GPL8673_Y37D8A_10P00210 | |||||||
GPL8673_Y37D8A_10P00430 | |||||||
GPL9450_Y37D8A.10 | |||||||
cea2.c.23647 | |||||||
Expression_cluster (90) | |||||||
Interaction (55) | |||||||
Map_info | Map | III | Position | 19.1628 | Error | 0.024664 | |
Positive | Positive_clone | Y37D8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00024200 | ||||||
WBPaper00035925 | |||||||
WBPaper00038444 | |||||||
WBPaper00038491 | |||||||
WBPaper00055090 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |