WormBase Tree Display for Gene: WBGene00006730

WBGene00006730 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F39B2
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: uev
    Allele (20)
    Strain: WBStrain00032660
      WBStrain00037221
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP1764
    Ortholog (42)
    Paralog (18)
    Structured_description: Concise_description: uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; UEV-1 activity is required cell autonomously for normal trafficking of the GLR-1 glutamate receptor and consequently, for normal locomotory behavior; UEV-1 physically interacts with the UBC-13 ubiquitin conjugating enzyme that is also required for normal locomotory behavior and that is also likely involved in the DNA damage response; a uev-1::gfp reporter fusion is expressed in a wide variety of tissues including the pharynx, neurons, muscle cells, vulva, intestine, distal tip cell, and cells in the anus/tail; UEV-1 reporter fusions localize to nuclei, the cytosol, and ventral cord neurites. Paper_evidence: WBPaper00005039
            WBPaper00005337
            WBPaper00037956
          Curator_confirmed: WBPerson1843
          Date_last_updated: 07 Feb 2011 00:00:00
      Automated_description: Enables ubiquitin conjugating enzyme binding activity. Involved in regulation of locomotion involved in locomotory behavior and regulation of protein localization to cell surface. Located in cytosol; neuron projection; and nucleus. Expressed in several structures, including anus; distal tip cell; germ line; neurons; and ventral nerve cord. Is an ortholog of human UBE2V2 (ubiquitin conjugating enzyme E2 V2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F39B2.2
    Corresponding_transcript: F39B2.2.1
    Other_sequence (59)
    Associated_feature: WBsf643859
      WBsf657109
      WBsf986228
      WBsf218828
  Experimental_info: RNAi_result: WBRNAi00116884 Inferred_automatically: RNAi_primary
      WBRNAi00003632 Inferred_automatically: RNAi_primary
      WBRNAi00046755 Inferred_automatically: RNAi_primary
      WBRNAi00076399 Inferred_automatically: RNAi_primary
      WBRNAi00082831 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9183
      Expr9184
      Expr9707
      Expr1010234
      Expr1032806
      Expr1150629
      Expr2017742
      Expr2035881
    Drives_construct: WBCnstr00013774
    Construct_product: WBCnstr00013774
      WBCnstr00013775
    Microarray_results: SMD_F39B2.2
      187984_at
      A_12_P119513
      Aff_F39B2.2
      GPL13394_WBGene00006730
      GPL13914_F39B2.2
      GPL14144_F39B2.2_232-291_0.938_12_C
      GPL14144_F39B2.2_318-377_0.973_1_A
      GPL14144_F39B2.2_56-115_0.944_8_B
      GPL19516_CGZ0020617
      GPL19516_CGZ0020618
      GPL21109_F39B2.2.1
      GPL3518_CE16008
      GPL8304_CE_WBGene00006730_A
      GPL8304_CE_WBGene00006730_B
      GPL8304_CE_WBGene00006730_C
      GPL8673_F39B2_2P00066
      GPL8673_F39B2_2P00167
      GPL8673_F39B2_2P00238
      GPL9450_F39B2.2
      cea2.c.03402
    Expression_cluster (117)
    Interaction (93)
  Map_info: Map: I Position: 26.8835 Error: 0.138356
    Positive: Positive_clone: F39B2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4669
    Pseudo_map_position
  Reference (16)
  Remark: Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb
    Sequence connection from [Boulton S, Vidal M]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene