WormBase Tree Display for Gene: WBGene00006368
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WBGene00006368 | SMap | S_parent | Sequence | C54H2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sym-3 | Person_evidence | WBPerson252 | |||||
Sequence_name | C54H2.1 | ||||||||
Molecular_name | C54H2.1a | ||||||||
C54H2.1a.1 | |||||||||
CE38303 | |||||||||
C54H2.1b | |||||||||
CE38304 | |||||||||
C54H2.1a.2 | |||||||||
C54H2.1b.1 | |||||||||
C54H2.1b.2 | |||||||||
Other_name | CELE_C54H2.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sym-3 | ||||||||
DB_info | Database | WormQTL | gene | WBGene00006368 | |||||
WormFlux | gene | WBGene00006368 | |||||||
NDB | locus_tag | CELE_C54H2.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006368|UniProtKB=Q86GI2 | |||||||
family | PTHR21456 | ||||||||
NCBI | gene | 183819 | |||||||
RefSeq | protein | NM_001029329.8 | |||||||
NM_001029330.3 | |||||||||
TREEFAM | TREEFAM_ID | TF320966 | |||||||
TrEMBL | UniProtAcc | Q86GI2 | |||||||
G5EE38 | |||||||||
UniProt_GCRP | UniProtAcc | Q86GI2 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sym | ||||||||
Allele (67) | |||||||||
Legacy_information | [Herman RK] sym-3(mn618) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation | ||||||||
Strain | WBStrain00034405 | ||||||||
WBStrain00034416 | |||||||||
RNASeq_FPKM (74) | |||||||||
Ortholog (40) | |||||||||
Structured_description | Concise_description | sym-3 encodes, by alternative splicing, two isoforms of a protein withno recognizably conserved domains, but with orthology to human FAM102A (EEIG1; OMIM:610891) and FAM102B, and to Drosophila CG8671; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding. | Paper_evidence | WBPaper00003663 | |||||
WBPaper00024639 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 04 May 2006 00:00:00 | ||||||||
Automated_description | Enriched in several structures, including ABalapapapa; ABalapppapa; ABplpaaappa; ABprpaaappa; and head neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-12; and eat-2 based on microarray; RNA-seq; and tiling array studies. Is affected by eight chemicals including Lithium Chloride; Zidovudine; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: NT-type C2 domain; EEIG1/2-like; and N-terminal C2 in EEIG1 and EHBP1 proteins. Is an ortholog of human EEIG1 (estrogen-induced osteoclastogenesis regulator 1) and EEIG2 (EEIG family member 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C54H2.1a | |||||||
C54H2.1b | |||||||||
Corresponding_CDS_history | C54H2.1:wp107 | ||||||||
C54H2.1:wp141 | |||||||||
Corresponding_transcript | C54H2.1a.1 | ||||||||
C54H2.1a.2 | |||||||||
C54H2.1b.1 | |||||||||
C54H2.1b.2 | |||||||||
Other_sequence (21) | |||||||||
Associated_feature (3) | |||||||||
Experimental_info | RNAi_result | WBRNAi00043193 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030166 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062556 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062555 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1020038 | ||||||||
Expr1032567 | |||||||||
Expr1147171 | |||||||||
Expr2017181 | |||||||||
Expr2035317 | |||||||||
Drives_construct | WBCnstr00034386 | ||||||||
Construct_product | WBCnstr00016047 | ||||||||
WBCnstr00034386 | |||||||||
Microarray_results | SMD_C54H2.1 | ||||||||
181950_at | |||||||||
A_12_P116761 | |||||||||
A_12_P140660 | |||||||||
A_12_P140661 | |||||||||
A_12_P140662 | |||||||||
Aff_C54H2.1 | |||||||||
GPL13394_WBGene00006368 | |||||||||
GPL13914_C54H2.1 | |||||||||
GPL14144_C54H2.1a_286-345_0.912_20_C | |||||||||
GPL14144_C54H2.1a_343-402_0.930_13_B | |||||||||
GPL14144_C54H2.1a_655-714_0.961_1_A | |||||||||
GPL19516_CGZ0010639 | |||||||||
GPL19516_CGZ0010640 | |||||||||
GPL21109_C54H2.1a | |||||||||
GPL21109_C54H2.1b | |||||||||
GPL3518_CE06983 | |||||||||
GPL8304_CE_WBGene00006368_A | |||||||||
GPL8304_CE_WBGene00006368_B | |||||||||
GPL8673_C54H2_1aP00441 | |||||||||
GPL8673_C54H2_1aP00658 | |||||||||
GPL8673_C54H2_1aP00854 | |||||||||
GPL8673_C54H2_1bP00185 | |||||||||
GPL8673_C54H2_1bP00366 | |||||||||
GPL8673_C54H2_1bP00418 | |||||||||
GPL9450_C54H2.1 | |||||||||
cea2.i.52000 | |||||||||
Expression_cluster (82) | |||||||||
Interaction | WBInteraction000052796 | ||||||||
WBInteraction000134120 | |||||||||
WBInteraction000134122 | |||||||||
WBInteraction000142067 | |||||||||
WBInteraction000318693 | |||||||||
WBInteraction000434495 | |||||||||
Map_info | Map | X | Position | -4.37222 | Error | 0.007269 | |||
Positive | Positive_clone | C54H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 7092 | |||||||
7093 | |||||||||
Reference (16) | |||||||||
Method | Gene |