WormBase Tree Display for Gene: WBGene00002163

WBGene00002163 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: ist-1 Person_evidence: WBPerson545
      Sequence_name: C54D1.3
      Molecular_name (12)
      Other_name: CELE_C54D1.3 Accession_evidence: NDB BX284606
      Public_name: ist-1
    DB_info: Database: AceView gene XH757
        WormQTL gene WBGene00002163
        WormFlux gene WBGene00002163
        NDB locus_tag CELE_C54D1.3
        NCBI gene 180978
        RefSeq protein NM_001330903.3
            NM_001373346.3
            NM_001373345.2
            NM_076800.7
        TrEMBL UniProtAcc A0A4V0IIP8
            A0A4V0INB3
            Q18820
            A0A1C3NSK8
        UniProt_GCRP UniProtAcc A0A4V0IIP8
    Species: Caenorhabditis elegans
    History: Version_change (2)
      Acquires_merge: WBGene00044576
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ist
    Allele (233)
    Strain: WBStrain00033295
      WBStrain00037950
    RNASeq_FPKM (74)
    GO_annotation: 00062458
      00062459
      00062460
      00062461
      00062462
      00062463
    Ortholog (28)
    Structured_description: Concise_description: ist-1 encodes a pleckstrin homology (PH) and phosphotyrosine binding (PTB) domain-containing insulin receptor substrate (IRS) homolog that negatively regulates lifespan and dauer development; IST-1 potentiates insulin-like signaling, although it is not absolutely required for such signaling under most conditions; in addition to acting through the AGE-1/PI3K branch of the insulin-like signaling pathway, IST-1 may also function in a parallel pathway to activate downstream protein-kinase Bs encoded by akt-1 and akt-2. Paper_evidence: WBPaper00005614
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info (5)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr1012662
      Expr1025581
      Expr1031266
      Expr1146049
      Expr1147097
      Expr2012871
      Expr2031105
    Drives_construct: WBCnstr00023456
      WBCnstr00036412
    Construct_product: WBCnstr00023456
      WBCnstr00036412
    Microarray_results: SMD_C54D1.2
      SMD_C54D1.3
      174720_at
      182353_at
      A_12_P101096
      Aff_C54D1.3
      GPL13394_WBGene00002163
      GPL13914_C54D1.3
      GPL14144_C36B7.8_82-141_0.947_1_A
      GPL14144_C54D1.3_2519-2578_0.915_9_B
      GPL14144_C54D1.3_2988-3047_0.951_2_A
      GPL14144_C54D1.3_950-1009_0.778_128_C
      GPL19516_CGZ0007908
      GPL19516_CGZ0010481
      GPL21109_C36B7.8
      GPL21109_C54D1.3
      GPL3518_CE30915
      GPL8304_CE_WBGene00002163_A
      GPL8304_CE_WBGene00002163_B
      GPL8304_CE_WBGene00044576_A
      GPL8673_C36B7_8P00019
      GPL8673_C36B7_8P00083
      GPL8673_C36B7_8P00133
      GPL8673_C54D1_3P01918
      GPL8673_C54D1_3P02747
      GPL8673_C54D1_3P02906
      GPL9450_C54D1.3
      cea2.p.138079
    Expression_cluster (196)
    Interaction (12)
  Map_info: Map: X Position: -1.82954 Error: 0.004648
    Positive: Positive_clone: C54D1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Sequence connection from [Wolkow C]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene