WormBase Tree Display for Gene: WBGene00001949
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WBGene00001949 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | hlh-2 | Person_evidence | WBPerson346 | |||||
Sequence_name | M05B5.5 | ||||||||
Molecular_name | M05B5.5a | ||||||||
M05B5.5a.1 | |||||||||
CE06191 | |||||||||
M05B5.5b | |||||||||
Other_name | CELE_M05B5.5 | Accession_evidence | NDB | BX284601 | |||||
Public_name | hlh-2 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | hlh | ||||||||
Allele (33) | |||||||||
Possibly_affected_by | WBVar02154068 | ||||||||
Legacy_information | [C.elegansII] NMK. Encodes homolog of vertebrate E12, Drosophila daughterless. lacZ fusion indicates transcription in some neuronal precursors. Antibody staining indicates all blastomere nuclei stain up to 200-cell stage, later expression complex, strong in head, ventral cord and tail at comma stage; fewer than 20 cells stain at hatching. Cosmid K07G5. [KM] | ||||||||
[Portman DS] bx108 and bx115 enhance the male tail ray-loss phenotype of lin-32 alleles, but have no noticeable phenotype in a wild-type background | |||||||||
Strain (6) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (76) | |||||||||
Ortholog (43) | |||||||||
Structured_description | Concise_description | hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates. | Paper_evidence | WBPaper00002826 | |||||
WBPaper00004492 | |||||||||
WBPaper00006120 | |||||||||
WBPaper00006303 | |||||||||
WBPaper00006354 | |||||||||
WBPaper00024330 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 26 Aug 2004 00:00:00 | ||||||||
Automated_description | Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein dimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of metabolic process; and sex differentiation. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including distal tip cell; enteric muscle; lateral ganglion; ray precursor cell; and terminal bulb. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Fuchs' endothelial dystrophy; Pitt-Hopkins syndrome; and agammaglobulinemia (multiple). Is an ortholog of human TCF12 (transcription factor 12); TCF3 (transcription factor 3); and TCF4 (transcription factor 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
Potential_model | DOID:3883 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11634) | |||||
DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11633) | ||||||
DOID:2340 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11623) | ||||||
DOID:0090070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11623) | ||||||
DOID:0060488 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11634) | ||||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11633) | ||||||
DOID:11555 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11634) | ||||||
DOID:0081140 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11633) | ||||||
DOID:0081143 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11633) | ||||||
Models_disease_in_annotation | WBDOannot00001265 | ||||||||
Molecular_info | Corresponding_CDS | M05B5.5a | |||||||
Corresponding_transcript | M05B5.5b | ||||||||
M05B5.5a.1 | |||||||||
Corresponding_pseudogene_history | M05B5.5b:wp122 | ||||||||
Other_sequence (12) | |||||||||
Associated_feature (17) | |||||||||
Gene_product_binds (22) | |||||||||
Transcription_factor | WBTranscriptionFactor000080 | ||||||||
WBTranscriptionFactor000063 | |||||||||
WBTranscriptionFactor000078 | |||||||||
WBTranscriptionFactor000076 | |||||||||
WBTranscriptionFactor000082 | |||||||||
WBTranscriptionFactor000083 | |||||||||
WBTranscriptionFactor000079 | |||||||||
WBTranscriptionFactor000084 | |||||||||
WBTranscriptionFactor000077 | |||||||||
WBTranscriptionFactor000081 | |||||||||
Experimental_info | RNAi_result (80) | ||||||||
Expr_pattern (20) | |||||||||
Drives_construct (20) | |||||||||
Construct_product (15) | |||||||||
Regulate_expr_cluster | WBPaper00059477:hlh-2(RNAi)_regulated | ||||||||
Antibody | WBAntibody00000147 | ||||||||
WBAntibody00001214 | |||||||||
WBAntibody00001643 | |||||||||
Microarray_results | SMD_M05B5.5 | ||||||||
173461_at | |||||||||
193176_s_at | |||||||||
A_12_P156230 | |||||||||
A_12_P156231 | |||||||||
A_12_P156232 | |||||||||
Aff_M05B5.5 | |||||||||
GPL13394_WBGene00001949 | |||||||||
GPL13914_M05B5.5 | |||||||||
GPL14144_M05B5.5a_419-478_0.918_15_C | |||||||||
GPL14144_M05B5.5a_831-890_0.928_8_B | |||||||||
GPL14144_M05B5.5a_953-1012_0.923_10_A | |||||||||
GPL19516_CGZ0030053 | |||||||||
GPL19516_CGZ0030054 | |||||||||
GPL21109_M05B5.5a | |||||||||
GPL21109_M05B5.5b | |||||||||
GPL3518_CE06191 | |||||||||
GPL8304_CE_WBGene00001949_A | |||||||||
GPL8673_M05B5_5aP00133 | |||||||||
GPL8673_M05B5_5aP00410 | |||||||||
GPL8673_M05B5_5aP00951 | |||||||||
Expression_cluster (200) | |||||||||
Interaction (108) | |||||||||
Map_info | Map | I | Position | 1.83482 | Error | 0.002317 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C01H6 | |||||||
F21E8 | |||||||||
M05B5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 3837 | |||||||
3838 | |||||||||
3839 | |||||||||
3840 | |||||||||
3841 | |||||||||
3842 | |||||||||
4521 | |||||||||
4760 | |||||||||
Reference (133) | |||||||||
Method | Gene |