WormBase Tree Display for Gene: WBGene00012354

WBGene00012354 SMap: S_parent: Sequence: W09C5
  Identity: Version: 2
    Name: CGC_name: cox-4 Person_evidence: WBPerson117
            WBPerson7169
      Sequence_name: W09C5.8
      Molecular_name: W09C5.8
        W09C5.8.1
        CE20171
      Other_name: CELE_W09C5.8 Accession_evidence: NDB BX284601
      Public_name: cox-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 05 Sep 2017 13:25:30 WBPerson2970 Name_change: CGC_name: cox-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cox
    Allele (24)
    Strain: WBStrain00037231
      WBStrain00022511
      WBStrain00047268
    RNASeq_FPKM (74)
    GO_annotation: 00099906
      00099907
      00099908
      00099909
      00099910
      00099911
      00099912
      00099913
      00119507
      00119508
    Ortholog (44)
    Structured_description: Concise_description: W09C5.8 encodes the C. elegans ortholog of the cytochrome c oxidase (COX) subunit IV (COX IV); loss of W09C5.8 activity via RNAi results in a shortened life span, reduced fertility, and defects in mitochondrial respiratory chain function. Paper_evidence: WBPaper00032427
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Nov 2010 00:00:00
      Automated_description: Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Is an ortholog of human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070501 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2265)
  Molecular_info: Corresponding_CDS: W09C5.8
    Corresponding_transcript: W09C5.8.1
    Other_sequence: Dviv_isotig03833
      NB07804
      NBC04061_1
      XI00475
      JO467760.1
      ES739202.1
      HG04820
      PP00514
      HBC28362_1
      EV851733.1
      DVC01249_1
      EX916528.1
      MC00533
      JI171741.1
      MH00985
      FE911027.1
      MCC05899_1
      NB07803
      CV198677.1
      ASC00655_1
      MCC01218_1
      Name_isotig05513
      NB07806
      EX538682.1
      EX913871.1
      HBC05058_1
      CR02615
      PPC00229_1
      CBC00197_1
      EX912655.1
      MIC07676_1
      Dviv_isotig03838
      Hbac_isotig01602
      PT00585
      DVC03433_1
      Dviv_isotig03835
      DA06101
      SSC02476_1
      BU088977.1
      HCC01740_1
      FC817364.1
      FE918292.1
      PTC03506_1
      AE00669
      CSC01526_1
      Tcir_isotig01132
      Oden_isotig20403
      ES412603.1
      EX013394.1
      DAC02271_1
      Name_isotig01761
      NB07807
      FG619302.1
      HGC11783_1
      HGC01954_1
      SSC02516_1
      CJC06219_1
      HBC03144_1
      FC811791.1
      XIC03641_1
      GRC02247_1
      ACC01155_1
      FE913189.1
      MCC05926_1
      AS00349
      HC03351
      JI182340.1
      Tcir_isotig01133
      ES410263.1
      MJ01139
      EX556272.1
      EX549251.1
      ES740449.1
      MC00061
      RS09453
      RSC02145_1
      SRC01450_1
      EX011724.1
      MC05233
      ES414131.1
      EX012698.1
      AS02782
      BUC01868_1
      NBC01721_1
      FE917091.1
      HC09599
      FG588761.1
      FE911622.1
      EX912490.1
      EX007352.1
      GW407900.1
      HG03322
      MAC03094_1
      AYC00481_1
      PSC00431_1
      FD515987.1
      Dviv_isotig03840
      MHC03035_1
      ASC24065_1
      CR09917
      ACC03012_1
      BXC00982_1
      SR02885
      EX012476.1
      EX553053.1
      NAC02436_1
      EV854124.1
      GR13129
      BXC02132_1
      Dviv_isotig03834
      CRC00340_1
      SSC06109_1
      Dviv_isotig03836
      ES741125.1
      Tcol_isotig16633
      AE00079
      Dviv_isotig03839
      PPC10391_1
      GR977380.1
      HG00001
      GO250386.1
      EX558719.1
      SS01480
      Dviv_isotig03837
      FE919751.1
      OOC03058_1
      CBC02087_1
      PVC00012_1
      FE914163.1
      MJC00170_1
      MA03117
    Associated_feature: WBsf649714
      WBsf655327
      WBsf220533
      WBsf220534
      WBsf220535
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr1028081
      Expr1035471
      Expr1158573
      Expr2006884
      Expr2025111
    Drives_construct: WBCnstr00029984
    Construct_product: WBCnstr00029984
    Microarray_results: SMD_W09C5.8
      178348_s_at
      A_12_P106700
      A_12_P139600
      A_12_P139601
      A_12_P139602
      A_12_P139603
      A_12_P139604
      Aff_W09C5.8
      GPL13394_WBGene00012354
      GPL13914_W09C5.8
      GPL14144_W09C5.8_206-265_0.851_3_B
      GPL14144_W09C5.8_427-486_0.723_9_C
      GPL14144_W09C5.8_475-534_0.973_1_A
      GPL19516_CGZ0038895
      GPL21109_W09C5.8
      GPL3518_CE20171
      GPL8304_CE_WBGene00012354_A
      GPL8673_W09C5_8P00003
      GPL8673_W09C5_8P00179
      GPL8673_W09C5_8P00458
      GPL9450_W09C5.8
      cea2.c.06888
    Expression_cluster (110)
    Interaction (76)
  Map_info: Map: I Position: 21.6359
    Positive: Positive_clone: W09C5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene