T14G8.3 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T14G8.3, its C. elegans paralog T24H7.2, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions.
Predicted to enable adenyl-nucleotide exchange factor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be part of endoplasmic reticulum chaperone complex. Human ortholog(s) of this gene implicated in immunodeficiency 59. Is an ortholog of human HYOU1 (hypoxia up-regulated 1).