WormBase Tree Display for Gene: WBGene00021697

WBGene00021697 SMap: S_parent: Sequence: Y48G9A
  Identity: Version: 3
    Name: CGC_name: gcn-1 Person_evidence: WBPerson644
      Sequence_name: Y48G9A.3
      Molecular_name: Y48G9A.3
        Y48G9A.3.1
        CE54096
      Other_name: Y48G9A.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.l Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.m Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.n Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y48G9A.o Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y48G9A.3 Accession_evidence: NDB BX284603
      Public_name: gcn-1
    DB_info: Database: AceView gene 3D249
        WormQTL gene WBGene00021697
        WormFlux gene WBGene00021697
        NDB locus_tag CELE_Y48G9A.3
        Panther gene CAEEL|WormBase=WBGene00021697|UniProtKB=B3CJ34
          family PTHR23346
        NCBI gene 190051
        RefSeq protein NM_001381763.1
        TREEFAM TREEFAM_ID TF105398
        TrEMBL UniProtAcc B3CJ34
        UniProt_GCRP UniProtAcc B3CJ34
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:04 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 15 Sep 2008 11:24:05 WBPerson2970 Name_change: CGC_name: gcn-1
        3 07 May 2008 11:46:03 WBPerson1867 Event: Acquires_merge: WBGene00021695
      Acquires_merge: WBGene00021695
        WBGene00021696
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gcn
    Allele (932)
    Strain: WBStrain00034488
      WBStrain00027623
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP3834
    Ortholog (53)
    Paralog: WBGene00008422 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010364 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: gcn-1 encodes the C. elegans ortholog of the S. cerevisiae ribosome-associated protein Gcn1p; GCN-1, along with ABCF-3, is required for maintaining the steady-state levels of phosphorylated eIF2alpha, and thus for the translational control of a number of mRNAs; GCN-1 activity is required, in parallel to, or downstream of, the canonical apoptotic pathway, for apoptotic cell death of most somatic cells and germ cells in response to ionizing radiation; in addition, GCN-1 is required for normal growth rates, and spatial organization of germ cells in the gonad; as in S. cerevisiae, GCN-1 physically interacts with ABCF-3, the C. elegans ortholog of budding yeast Gcn20p, and GCN-1 and ABCF-3 are each required for the other's stability; a gcn-1::gfp promoter fusion is expressed in most cells, including germ cells, throughout development. Paper_evidence: WBPaper00045601
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Aug 2014 00:00:00
      Automated_description: Predicted to enable protein kinase regulator activity. Involved in positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; and regulation of translation. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within with a negative effect on negative regulation of translation. Predicted to be located in cytosolic ribosome. Expressed in several structures, including body wall musculature; head neurons; hermaphrodite gonad; intestinal cell; and pharyngeal neurons. Is an ortholog of human GCN1 (GCN1 activator of EIF2AK4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y48G9A.3
    Corresponding_CDS_history: Y48G9A.3:wp150
      Y48G9A.3:wp191
      Y48G9A.3:wp237
      Y48G9A.3:wp275
    Corresponding_transcript: Y48G9A.3.1
    Other_sequence (91)
    Associated_feature (40)
  Experimental_info: RNAi_result: WBRNAi00056982 Inferred_automatically: RNAi_primary
      WBRNAi00056977 Inferred_automatically: RNAi_primary
      WBRNAi00037280 Inferred_automatically: RNAi_primary
      WBRNAi00093045 Inferred_automatically: RNAi_primary
      WBRNAi00077044 Inferred_automatically: RNAi_primary
      WBRNAi00037275 Inferred_automatically: RNAi_primary
      WBRNAi00056981 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11922
      Expr11923
      Expr1022586
      Expr1039504
      Expr1160428
      Expr2011967
      Expr2030204
    Drives_construct: WBCnstr00019541
    Construct_product: WBCnstr00019540
    Regulate_expr_cluster: WBPaper00065578:gcn-1(nc40)_downregulated
      WBPaper00065578:gcn-1(nc40)_upregulated
    Antibody: WBAntibody00002554
    Microarray_results (42)
    Expression_cluster (163)
    Interaction: WBInteraction000009103
      WBInteraction000009105
      WBInteraction000103183
      WBInteraction000104127
      WBInteraction000109809
      WBInteraction000112894
      WBInteraction000133058
      WBInteraction000133085
      WBInteraction000178771
      WBInteraction000191658
      WBInteraction000200007
      WBInteraction000200008
      WBInteraction000209115
      WBInteraction000216959
      WBInteraction000216960
      WBInteraction000224440
      WBInteraction000224445
      WBInteraction000231159
      WBInteraction000243383
      WBInteraction000243398
      WBInteraction000243405
      WBInteraction000243416
      WBInteraction000243434
      WBInteraction000243444
      WBInteraction000243572
      WBInteraction000243620
      WBInteraction000243643
      WBInteraction000243685
      WBInteraction000243730
      WBInteraction000243751
      WBInteraction000243768
      WBInteraction000243818
      WBInteraction000243848
      WBInteraction000243888
      WBInteraction000243909
      WBInteraction000243950
      WBInteraction000243972
      WBInteraction000243997
      WBInteraction000244034
      WBInteraction000244073
      WBInteraction000244094
      WBInteraction000244928
      WBInteraction000267471
      WBInteraction000267986
      WBInteraction000276514
      WBInteraction000288220
      WBInteraction000290164
      WBInteraction000295949
      WBInteraction000299582
      WBInteraction000300731
      WBInteraction000300732
      WBInteraction000309335
      WBInteraction000313654
      WBInteraction000316062
      WBInteraction000319562
      WBInteraction000331226
      WBInteraction000331449
      WBInteraction000333996
      WBInteraction000337044
      WBInteraction000340217
      WBInteraction000344920
      WBInteraction000344921
      WBInteraction000344922
      WBInteraction000344923
      WBInteraction000344924
      WBInteraction000344925
      WBInteraction000344926
      WBInteraction000344927
      WBInteraction000344928
      WBInteraction000344929
      WBInteraction000344930
      WBInteraction000344931
      WBInteraction000344932
      WBInteraction000344933
      WBInteraction000344934
      WBInteraction000344935
      WBInteraction000346716
      WBInteraction000354883
      WBInteraction000359405
      WBInteraction000368113
      WBInteraction000368540
      WBInteraction000372594
      WBInteraction000373055
      WBInteraction000375535
      WBInteraction000385401
      WBInteraction000386532
      WBInteraction000389336
      WBInteraction000402457
      WBInteraction000412262
      WBInteraction000422580
      WBInteraction000426162
      WBInteraction000431116
      WBInteraction000434410
      WBInteraction000434733
      WBInteraction000437362
      WBInteraction000439323
      WBInteraction000441990
      WBInteraction000442433
      WBInteraction000447354
      WBInteraction000455776
      WBInteraction000461270
      WBInteraction000462831
      WBInteraction000462832
      WBInteraction000465195
      WBInteraction000465230
      WBInteraction000465471
      WBInteraction000465633
      WBInteraction000465710
      WBInteraction000465935
      WBInteraction000467355
      WBInteraction000467402
      WBInteraction000467531
      WBInteraction000467688
      WBInteraction000467803
      WBInteraction000468984
      WBInteraction000469327
      WBInteraction000469476
      WBInteraction000469477
      WBInteraction000469478
      WBInteraction000469479
      WBInteraction000469671
      WBInteraction000471281
      WBInteraction000471720
      WBInteraction000471821
      WBInteraction000472832
      WBInteraction000473061
      WBInteraction000473697
      WBInteraction000474691
      WBInteraction000524349
      WBInteraction000536193
      WBInteraction000536195
      WBInteraction000536196
      WBInteraction000536197
      WBInteraction000536202
      WBInteraction000536203
      WBInteraction000543429
      WBInteraction000550242
      WBInteraction000551954
      WBInteraction000555315
      WBInteraction000556807
      WBInteraction000564949
      WBInteraction000565336
      WBInteraction000565432
      WBInteraction000567398
      WBInteraction000571883
      WBInteraction000574663
      WBInteraction000576994
      WBInteraction000579253
      WBInteraction000586117
      WBInteraction000586462
  Map_info: Map: III Position: -15.0586 Error: 0.039572
    Positive: Positive_clone: Y48G9A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene