WormBase Tree Display for Gene: WBGene00012342

WBGene00012342 SMap: S_parent: Sequence: W08D2
  Identity: Version: 2
    Name: CGC_name: mtr-4 Person_evidence: WBPerson699
            WBPerson6229
      Sequence_name: W08D2.7
      Molecular_name: W08D2.7
        W08D2.7.1
        CE06562
      Other_name: CELE_W08D2.7 Accession_evidence: NDB BX284604
      Public_name: mtr-4
    DB_info: Database: AceView gene 4K593
        WormQTL gene WBGene00012342
        WormFlux gene WBGene00012342
        NDB locus_tag CELE_W08D2.7
        Panther gene CAEEL|WormBase=WBGene00012342|UniProtKB=Q23223
          family PTHR12131
        NCBI gene 177824
        RefSeq protein NM_069356.6
        SwissProt UniProtAcc Q23223
        TREEFAM TREEFAM_ID TF300597
        UniProt_GCRP UniProtAcc Q23223
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 04 Jun 2007 15:54:19 WBPerson2970 Name_change: CGC_name: mtr-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mtr
    Allele (58)
    Possibly_affected_by: WBVar02153240
      WBVar02153242
    Strain: WBStrain00002572
      WBStrain00032681
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (43)
    Paralog: WBGene00008502 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012896 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013189 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016194 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020964 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021905 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mtr-4 encodes the C. elegans homolog of Saccharomyces cerevisiae Mtr4p, an RNA helicase that functions as part of the TRAMP complex that regulates polyadenylation of mRNAs destined for decay or exosomal trimming; loss of mtr-4 activity results in a variety of defects, including defects in germ line development; MTR-4 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo. Paper_evidence: WBPaper00040686
            WBPaper00032961
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Jan 2012 00:00:00
      Automated_description: Predicted to enable RNA helicase activity. Predicted to be involved in RNA catabolic process and maturation of 5.8S rRNA. Predicted to be located in nucleus. Expressed in PVDL; PVDR; embryonic cell; and somatic cell. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is an ortholog of human MTREX (Mtr4 exosome RNA helicase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:332 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18734)
  Molecular_info: Corresponding_CDS: W08D2.7
    Corresponding_transcript: W08D2.7.1
    Other_sequence (60)
    Associated_feature: WBsf646257
      WBsf228881
  Experimental_info: RNAi_result (30)
    Expr_pattern: Chronogram744
      Expr6854
      Expr12216
      Expr12227
      Expr15665
      Expr1011473
      Expr1035462
      Expr1158512
      Expr2013816
      Expr2032056
    Drives_construct: WBCnstr00003134
      WBCnstr00020415
      WBCnstr00029987
    Construct_product: WBCnstr00020470
      WBCnstr00029987
      WBCnstr00042026
      WBCnstr00042029
    Microarray_results (22)
    Expression_cluster (126)
    Interaction: WBInteraction000036220
      WBInteraction000036504
      WBInteraction000039165
      WBInteraction000041628
      WBInteraction000042410
      WBInteraction000042445
      WBInteraction000042446
      WBInteraction000042447
      WBInteraction000042448
      WBInteraction000044122
      WBInteraction000045059
      WBInteraction000045060
      WBInteraction000048557
      WBInteraction000048646
      WBInteraction000050371
      WBInteraction000050569
      WBInteraction000051870
      WBInteraction000051903
      WBInteraction000112039
      WBInteraction000114494
      WBInteraction000120038
      WBInteraction000124503
      WBInteraction000136067
      WBInteraction000141603
      WBInteraction000141915
      WBInteraction000143534
      WBInteraction000145142
      WBInteraction000150015
      WBInteraction000151861
      WBInteraction000156540
      WBInteraction000159264
      WBInteraction000159699
      WBInteraction000160844
      WBInteraction000160882
      WBInteraction000161637
      WBInteraction000163281
      WBInteraction000168770
      WBInteraction000169112
      WBInteraction000169832
      WBInteraction000169902
      WBInteraction000169926
      WBInteraction000169981
      WBInteraction000174823
      WBInteraction000176135
      WBInteraction000176368
      WBInteraction000178575
      WBInteraction000179560
      WBInteraction000181718
      WBInteraction000182131
      WBInteraction000187251
      WBInteraction000187367
      WBInteraction000194628
      WBInteraction000196759
      WBInteraction000197320
      WBInteraction000199520
      WBInteraction000201614
      WBInteraction000202655
      WBInteraction000205764
      WBInteraction000211589
      WBInteraction000215749
      WBInteraction000216594
      WBInteraction000218318
      WBInteraction000222136
      WBInteraction000224990
      WBInteraction000230123
      WBInteraction000232617
      WBInteraction000232896
      WBInteraction000233146
      WBInteraction000233147
      WBInteraction000233170
      WBInteraction000237769
      WBInteraction000237779
      WBInteraction000239898
      WBInteraction000242879
      WBInteraction000255168
      WBInteraction000258286
      WBInteraction000259896
      WBInteraction000260222
      WBInteraction000260323
      WBInteraction000261535
      WBInteraction000265028
      WBInteraction000267235
      WBInteraction000269146
      WBInteraction000270348
      WBInteraction000272098
      WBInteraction000273988
      WBInteraction000277936
      WBInteraction000278638
      WBInteraction000280246
      WBInteraction000284777
      WBInteraction000290456
      WBInteraction000293375
      WBInteraction000298292
      WBInteraction000299177
      WBInteraction000303229
      WBInteraction000304822
      WBInteraction000307844
      WBInteraction000312605
      WBInteraction000324666
      WBInteraction000324953
      WBInteraction000330371
      WBInteraction000335605
      WBInteraction000337254
      WBInteraction000341600
      WBInteraction000360145
      WBInteraction000370706
      WBInteraction000370800
      WBInteraction000373251
      WBInteraction000377320
      WBInteraction000383643
      WBInteraction000385618
      WBInteraction000386117
      WBInteraction000390352
      WBInteraction000391826
      WBInteraction000392868
      WBInteraction000393427
      WBInteraction000395456
      WBInteraction000395496
      WBInteraction000401831
      WBInteraction000402948
      WBInteraction000403804
      WBInteraction000404198
      WBInteraction000404739
      WBInteraction000407538
      WBInteraction000408073
      WBInteraction000428943
      WBInteraction000429240
      WBInteraction000429759
      WBInteraction000432101
      WBInteraction000432742
      WBInteraction000432974
      WBInteraction000432986
      WBInteraction000435069
      WBInteraction000436651
      WBInteraction000438613
      WBInteraction000439893
      WBInteraction000442322
      WBInteraction000443597
      WBInteraction000445920
      WBInteraction000448656
      WBInteraction000452593
      WBInteraction000452814
      WBInteraction000456134
      WBInteraction000456585
      WBInteraction000456738
      WBInteraction000456902
      WBInteraction000457586
      WBInteraction000458185
      WBInteraction000459270
      WBInteraction000459323
      WBInteraction000459609
      WBInteraction000459754
      WBInteraction000462719
      WBInteraction000462756
      WBInteraction000462773
      WBInteraction000462975
      WBInteraction000462977
      WBInteraction000464015
      WBInteraction000464114
      WBInteraction000464124
      WBInteraction000464987
      WBInteraction000465626
      WBInteraction000465842
      WBInteraction000466437
      WBInteraction000466791
      WBInteraction000466880
      WBInteraction000467615
      WBInteraction000468101
      WBInteraction000468636
      WBInteraction000468742
      WBInteraction000470134
      WBInteraction000470813
      WBInteraction000471052
      WBInteraction000471053
      WBInteraction000472300
      WBInteraction000473270
      WBInteraction000474487
      WBInteraction000474747
      WBInteraction000475223
      WBInteraction000475408
      WBInteraction000502521
      WBInteraction000534767
      WBInteraction000549133
      WBInteraction000551989
      WBInteraction000555409
      WBInteraction000559540
      WBInteraction000565006
      WBInteraction000570057
      WBInteraction000570602
      WBInteraction000570603
      WBInteraction000570604
      WBInteraction000573740
      WBInteraction000575431
  Map_info: Map: IV Position: 4.42878 Error: 0.000727
    Positive: Positive_clone: W08D2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00032961
    WBPaper00038491
    WBPaper00046432
    WBPaper00055090
    WBPaper00060530
    WBPaper00064201
    WBPaper00065012
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene