WormBase Tree Display for Gene: WBGene00009218

WBGene00009218 SMap: S_parent: Sequence: F28D1
  Identity: Version: 2
    Name: CGC_name: acs-20 Person_evidence: WBPerson237
            WBPerson2239
      Sequence_name: F28D1.9
      Molecular_name: F28D1.9
        F28D1.9.1
        CE47963
      Other_name: CELE_F28D1.9 Accession_evidence: NDB BX284604
      Public_name: acs-20
    DB_info: Database: AceView gene 4N158
        WormQTL gene WBGene00009218
        WormFlux gene WBGene00009218
        NDB locus_tag CELE_F28D1.9
        Panther gene CAEEL|WormBase=WBGene00009218|UniProtKB=Q19878
          family PTHR43107
        NCBI gene 178190
        RefSeq protein NM_069966.10
        TrEMBL UniProtAcc Q19878
        UniProt_GCRP UniProtAcc Q19878
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Sep 2008 09:57:25 WBPerson2970 Name_change: CGC_name: acs-20
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acs
    Allele (88)
    Strain (2)
    RNASeq_FPKM (74)
    GO_annotation: 00066220
      00066221
      00066222
      00066223
      00066224
      00066225
      00066226
      00066227
    Ortholog (42)
    Paralog (17)
    Structured_description: Concise_description: acs-20 encodes a protein homologous to the mammalian FATP1 and FATP4 fatty acid transport proteins (FATP)/very long chain fatty acid acyl-CoA synthetases; acs-20 activity is required for proper cuticle development, specifically formation of a cuticle surface barrier that prevents penetration of small molecules; acs-20 may affect cuticle development via its role in incorporation of very long chain fatty acids, but not other fatty acids, into sphingomyelin; acs-20; acs-22 doubly mutant animals have moresevere cuticle barrier defects than acs-20 single mutants, suggesting that the two genes function redundantly; acs-20 defects can be rescued by human Fatp4; an ACS-20::GFP fusion protein is expressed in the hyp7 and seam hypodermis, as well as the vulval and anal muscles; in hypodermal cells, ACS-20 localizes in a reticular pattern suggestive of localization to the endoplasmic reticulum. Paper_evidence: WBPaper00035868
          Curator_confirmed: WBPerson1843
          Date_last_updated: 03 Feb 2010 00:00:00
      Automated_description: Predicted to enable long-chain fatty acid transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in triglyceride homeostasis. Located in intracellular membrane-bounded organelle. Expressed in anal depressor muscle; anal sphincter muscle; head; hyp7 syncytium; and seam cell. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10998)
  Molecular_info: Corresponding_CDS: F28D1.9
    Corresponding_CDS_history: F28D1.9:wp154
    Corresponding_transcript: F28D1.9.1
    Other_sequence (33)
    Associated_feature (13)
  Experimental_info: RNAi_result (23)
    Expr_pattern: Chronogram984
      Expr5903
      Expr8893
      Expr8895
      Expr1026843
      Expr1034021
      Expr1149741
      Expr2009210
      Expr2027447
    Drives_construct: WBCnstr00002507
      WBCnstr00007265
      WBCnstr00013587
      WBCnstr00013589
      WBCnstr00022750
      WBCnstr00022752
      WBCnstr00032361
    Construct_product: WBCnstr00007265
      WBCnstr00013589
      WBCnstr00022752
      WBCnstr00022754
      WBCnstr00032361
    Microarray_results (17)
    Expression_cluster (233)
    Interaction: WBInteraction000007813
      WBInteraction000038163
      WBInteraction000046041
      WBInteraction000046043
      WBInteraction000046045
      WBInteraction000046047
      WBInteraction000046049
      WBInteraction000110986
      WBInteraction000119109
      WBInteraction000121097
      WBInteraction000124325
      WBInteraction000127377
      WBInteraction000139672
      WBInteraction000139724
      WBInteraction000139728
      WBInteraction000139776
      WBInteraction000139807
      WBInteraction000139815
      WBInteraction000141024
      WBInteraction000143475
      WBInteraction000143575
      WBInteraction000144595
      WBInteraction000147023
      WBInteraction000148766
      WBInteraction000149072
      WBInteraction000150337
      WBInteraction000150766
      WBInteraction000164513
      WBInteraction000164514
      WBInteraction000164645
      WBInteraction000168175
      WBInteraction000171342
      WBInteraction000172543
      WBInteraction000172807
      WBInteraction000176800
      WBInteraction000177283
      WBInteraction000178792
      WBInteraction000180141
      WBInteraction000182904
      WBInteraction000183634
      WBInteraction000184007
      WBInteraction000184618
      WBInteraction000185285
      WBInteraction000188001
      WBInteraction000191846
      WBInteraction000192266
      WBInteraction000194831
      WBInteraction000195352
      WBInteraction000196976
      WBInteraction000197414
      WBInteraction000199352
      WBInteraction000204835
      WBInteraction000205766
      WBInteraction000206971
      WBInteraction000207633
      WBInteraction000207634
      WBInteraction000208284
      WBInteraction000208924
      WBInteraction000209516
      WBInteraction000211093
      WBInteraction000211195
      WBInteraction000213381
      WBInteraction000213382
      WBInteraction000214251
      WBInteraction000222175
      WBInteraction000222297
      WBInteraction000222301
      WBInteraction000223006
      WBInteraction000226052
      WBInteraction000226204
      WBInteraction000229312
      WBInteraction000229692
      WBInteraction000231027
      WBInteraction000235273
      WBInteraction000235292
      WBInteraction000236246
      WBInteraction000239388
      WBInteraction000239797
      WBInteraction000244977
      WBInteraction000245037
      WBInteraction000245240
      WBInteraction000245396
      WBInteraction000245432
      WBInteraction000245582
      WBInteraction000245734
      WBInteraction000249295
      WBInteraction000249515
      WBInteraction000255563
      WBInteraction000256082
      WBInteraction000257544
      WBInteraction000259344
      WBInteraction000265065
      WBInteraction000268426
      WBInteraction000268919
      WBInteraction000270214
      WBInteraction000274912
      WBInteraction000277206
      WBInteraction000283233
      WBInteraction000283271
      WBInteraction000283531
      WBInteraction000286742
      WBInteraction000293396
      WBInteraction000293641
      WBInteraction000298799
      WBInteraction000298942
      WBInteraction000301822
      WBInteraction000302353
      WBInteraction000303868
      WBInteraction000304076
      WBInteraction000304507
      WBInteraction000306308
      WBInteraction000310716
      WBInteraction000315637
      WBInteraction000316090
      WBInteraction000317297
      WBInteraction000319812
      WBInteraction000319870
      WBInteraction000324761
      WBInteraction000326156
      WBInteraction000326928
      WBInteraction000331297
      WBInteraction000332258
      WBInteraction000332432
      WBInteraction000341968
      WBInteraction000343933
      WBInteraction000343999
      WBInteraction000346967
      WBInteraction000348869
      WBInteraction000352525
      WBInteraction000354173
      WBInteraction000354174
      WBInteraction000359312
      WBInteraction000362553
      WBInteraction000362794
      WBInteraction000366071
      WBInteraction000368454
      WBInteraction000380264
      WBInteraction000383584
      WBInteraction000384812
      WBInteraction000387422
      WBInteraction000390398
      WBInteraction000393306
      WBInteraction000404749
      WBInteraction000409480
      WBInteraction000412252
      WBInteraction000413450
      WBInteraction000415927
      WBInteraction000418646
      WBInteraction000419487
      WBInteraction000421486
      WBInteraction000424993
      WBInteraction000426526
      WBInteraction000427435
      WBInteraction000431091
      WBInteraction000431658
      WBInteraction000434715
      WBInteraction000435592
      WBInteraction000440305
      WBInteraction000441093
      WBInteraction000442382
      WBInteraction000452058
      WBInteraction000452844
      WBInteraction000453574
      WBInteraction000455830
      WBInteraction000456668
      WBInteraction000456859
      WBInteraction000462945
      WBInteraction000462946
      WBInteraction000464380
      WBInteraction000464502
      WBInteraction000465258
      WBInteraction000520263
      WBInteraction000582799
  Map_info: Map: IV Position: 5.90843 Error: 0.002883
    Positive: Positive_clone: F28D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene