WormBase Tree Display for Gene: WBGene00006706

WBGene00006706 SMap: S_parent: Sequence: F29B9
  Identity: Version: 1
    Name (5)
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ubc
    Allele (21)
    Strain: WBStrain00004050
      WBStrain00034466
      WBStrain00034467
    RNASeq_FPKM (74)
    GO_annotation (33)
    Contained_in_operon: CEOP4128
    Ortholog (41)
    Paralog (18)
    Structured_description: Concise_description: ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair. Paper_evidence: WBPaper00005039
            WBPaper00005337
            WBPaper00012383
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; SAM domain binding activity; and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; pharyngeal muscle development; and protein sumoylation. Predicted to be located in nucleus. Expressed in body wall musculature; coelomocyte; pharynx; tail; and in male. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; ovarian cancer; and urinary bladder cancer. Is an ortholog of human UBE2I (ubiquitin conjugating enzyme E2 I). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12485)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12485)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12485)
  Molecular_info: Corresponding_CDS: F29B9.6
    Corresponding_transcript: F29B9.6.1
    Other_sequence (69)
    Associated_feature: WBsf645940
      WBsf645941
      WBsf981746
      WBsf996355
      WBsf228217
      WBsf228218
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr11863
      Expr13765
      Expr1015118
      Expr1032789
      Expr1149806
      Expr2017717
      Expr2035855
    Drives_construct: WBCnstr00019675
      WBCnstr00034201
    Construct_product: WBCnstr00034201
    Regulate_expr_cluster: WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
    Antibody: WBAntibody00002527
      WBAntibody00002604
    Microarray_results (28)
    Expression_cluster (150)
    Interaction: WBInteraction000003898
      WBInteraction000005390
      WBInteraction000005391
      WBInteraction000005392
      WBInteraction000007752
      WBInteraction000007769
      WBInteraction000007794
      WBInteraction000028985
      WBInteraction000029272
      WBInteraction000033842
      WBInteraction000033917
      WBInteraction000033918
      WBInteraction000035016
      WBInteraction000038383
      WBInteraction000039575
      WBInteraction000041340
      WBInteraction000041895
      WBInteraction000042305
      WBInteraction000043108
      WBInteraction000045248
      WBInteraction000046577
      WBInteraction000047499
      WBInteraction000047586
      WBInteraction000047836
      WBInteraction000049516
      WBInteraction000050198
      WBInteraction000110670
      WBInteraction000110701
      WBInteraction000110715
      WBInteraction000115955
      WBInteraction000136797
      WBInteraction000136923
      WBInteraction000136924
      WBInteraction000136925
      WBInteraction000140898
      WBInteraction000140899
      WBInteraction000144286
      WBInteraction000147225
      WBInteraction000147226
      WBInteraction000151785
      WBInteraction000152454
      WBInteraction000160282
      WBInteraction000161335
      WBInteraction000161828
      WBInteraction000161849
      WBInteraction000162555
      WBInteraction000164157
      WBInteraction000165732
      WBInteraction000167645
      WBInteraction000167646
      WBInteraction000167647
      WBInteraction000173227
      WBInteraction000173269
      WBInteraction000173282
      WBInteraction000173303
      WBInteraction000173315
      WBInteraction000173343
      WBInteraction000173978
      WBInteraction000173979
      WBInteraction000173980
      WBInteraction000173981
      WBInteraction000173982
      WBInteraction000173983
      WBInteraction000173984
      WBInteraction000173985
      WBInteraction000173986
      WBInteraction000173987
      WBInteraction000173988
      WBInteraction000173989
      WBInteraction000180109
      WBInteraction000198229
      WBInteraction000221367
      WBInteraction000221633
      WBInteraction000224823
      WBInteraction000226238
      WBInteraction000233121
      WBInteraction000236657
      WBInteraction000240539
      WBInteraction000240666
      WBInteraction000241795
      WBInteraction000246594
      WBInteraction000252433
      WBInteraction000264886
      WBInteraction000264887
      WBInteraction000264888
      WBInteraction000266003
      WBInteraction000274495
      WBInteraction000279092
      WBInteraction000284075
      WBInteraction000288433
      WBInteraction000295682
      WBInteraction000300107
      WBInteraction000311166
      WBInteraction000314494
      WBInteraction000322116
      WBInteraction000328927
      WBInteraction000336225
      WBInteraction000339662
      WBInteraction000339663
      WBInteraction000339731
      WBInteraction000339803
      WBInteraction000339804
      WBInteraction000339805
      WBInteraction000339806
      WBInteraction000339807
      WBInteraction000339808
      WBInteraction000339809
      WBInteraction000339810
      WBInteraction000339811
      WBInteraction000339812
      WBInteraction000339822
      WBInteraction000339848
      WBInteraction000361666
      WBInteraction000368697
      WBInteraction000380116
      WBInteraction000386896
      WBInteraction000387894
      WBInteraction000387978
      WBInteraction000388285
      WBInteraction000388297
      WBInteraction000388303
      WBInteraction000390120
      WBInteraction000390721
      WBInteraction000390964
      WBInteraction000401434
      WBInteraction000412590
      WBInteraction000431473
      WBInteraction000442402
      WBInteraction000452874
      WBInteraction000454317
      WBInteraction000467605
      WBInteraction000468002
      WBInteraction000500869
      WBInteraction000501979
      WBInteraction000501982
      WBInteraction000501983
      WBInteraction000502384
      WBInteraction000509050
      WBInteraction000520058
      WBInteraction000522779
      WBInteraction000522783
      WBInteraction000523213
      WBInteraction000523860
      WBInteraction000525241
      WBInteraction000539455
      WBInteraction000539463
      WBInteraction000539578
      WBInteraction000539809
      WBInteraction000540178
      WBInteraction000540620
      WBInteraction000542168
      WBInteraction000542305
      WBInteraction000542306
      WBInteraction000542307
      WBInteraction000542308
      WBInteraction000542309
      WBInteraction000543045
      WBInteraction000547515
      WBInteraction000547935
      WBInteraction000547936
      WBInteraction000547937
      WBInteraction000547938
      WBInteraction000549658
      WBInteraction000551001
      WBInteraction000551255
      WBInteraction000552147
      WBInteraction000553836
      WBInteraction000554558
      WBInteraction000555265
      WBInteraction000556224
      WBInteraction000559238
      WBInteraction000562546
      WBInteraction000562547
      WBInteraction000573319
      WBInteraction000573606
      WBInteraction000576395
      WBInteraction000579157
      WBInteraction000580466
      WBInteraction000586337
      WBInteraction000522001
      WBInteraction000522002
  Map_info: Map: IV Position: 0.518478 Error: 0.015777
    Positive: Positive_clone: F29B9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (41)
  Remark: Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene