WormBase Tree Display for Gene: WBGene00004391

WBGene00004391 SMap: S_parent: Sequence: T23G5
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: rnr
    Allele (36)
    Strain: WBStrain00002226
      WBStrain00007244
      WBStrain00007246
      WBStrain00001716
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (47)
    Structured_description: Concise_description: rnr-1 encodes the large subunit of ribonucleotide reductase; by homology, RNR-1 is predicted to function in deoxyribonucleotide biosynthesis; in C. elegans rnr-1 is an essential gene whose activity is required for reproduction and embryonic development. Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Aug 2007 00:00:00
      Automated_description: Predicted to enable ATP binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be part of ribonucleoside-diphosphate reductase complex. Expressed in head; somatic gonad precursor; and tail. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human RRM1 (ribonucleotide reductase catalytic subunit M1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10451)
      DOID:12558 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10451)
  Molecular_info: Corresponding_CDS: T23G5.1
    Corresponding_transcript: T23G5.1.1
      T23G5.1.2
    Other_sequence (105)
    Associated_feature (15)
  Experimental_info: RNAi_result (25)
    Expr_pattern (11)
    Drives_construct: WBCnstr00000444
      WBCnstr00000446
      WBCnstr00000447
      WBCnstr00000929
      WBCnstr00002540
      WBCnstr00004370
      WBCnstr00007949
      WBCnstr00008139
      WBCnstr00035516
    Construct_product: WBCnstr00035516
    Antibody: WBAntibody00001448
    Microarray_results (21)
    Expression_cluster (236)
    Interaction: WBInteraction000008450
      WBInteraction000008451
      WBInteraction000008452
      WBInteraction000008453
      WBInteraction000036314
      WBInteraction000036751
      WBInteraction000037782
      WBInteraction000037869
      WBInteraction000038002
      WBInteraction000038182
      WBInteraction000038796
      WBInteraction000040027
      WBInteraction000040099
      WBInteraction000040642
      WBInteraction000040643
      WBInteraction000042241
      WBInteraction000042870
      WBInteraction000043227
      WBInteraction000044227
      WBInteraction000044881
      WBInteraction000045465
      WBInteraction000045718
      WBInteraction000046086
      WBInteraction000046087
      WBInteraction000046404
      WBInteraction000046494
      WBInteraction000047095
      WBInteraction000047494
      WBInteraction000049104
      WBInteraction000049615
      WBInteraction000049682
      WBInteraction000050188
      WBInteraction000103391
      WBInteraction000113238
      WBInteraction000114983
      WBInteraction000118113
      WBInteraction000118638
      WBInteraction000121455
      WBInteraction000127124
      WBInteraction000133182
      WBInteraction000138492
      WBInteraction000142672
      WBInteraction000147692
      WBInteraction000155207
      WBInteraction000155452
      WBInteraction000155524
      WBInteraction000155527
      WBInteraction000155888
      WBInteraction000156384
      WBInteraction000160984
      WBInteraction000164323
      WBInteraction000171698
      WBInteraction000175770
      WBInteraction000188042
      WBInteraction000189644
      WBInteraction000193938
      WBInteraction000199263
      WBInteraction000206104
      WBInteraction000206899
      WBInteraction000212718
      WBInteraction000223102
      WBInteraction000225456
      WBInteraction000225457
      WBInteraction000233999
      WBInteraction000237988
      WBInteraction000243273
      WBInteraction000247201
      WBInteraction000248345
      WBInteraction000277791
      WBInteraction000277792
      WBInteraction000277798
      WBInteraction000282512
      WBInteraction000284064
      WBInteraction000294593
      WBInteraction000296233
      WBInteraction000306441
      WBInteraction000310015
      WBInteraction000313745
      WBInteraction000319896
      WBInteraction000323214
      WBInteraction000327334
      WBInteraction000331005
      WBInteraction000331414
      WBInteraction000340948
      WBInteraction000346947
      WBInteraction000387432
      WBInteraction000388776
      WBInteraction000393311
      WBInteraction000396931
      WBInteraction000397565
      WBInteraction000399204
      WBInteraction000399577
      WBInteraction000408072
      WBInteraction000408986
      WBInteraction000426093
      WBInteraction000438114
      WBInteraction000439777
      WBInteraction000444925
      WBInteraction000449871
      WBInteraction000451531
      WBInteraction000453334
      WBInteraction000458777
      WBInteraction000463238
      WBInteraction000464942
      WBInteraction000465134
      WBInteraction000465565
      WBInteraction000465566
      WBInteraction000465635
      WBInteraction000466156
      WBInteraction000466269
      WBInteraction000467575
      WBInteraction000468342
      WBInteraction000469173
      WBInteraction000469773
      WBInteraction000469864
      WBInteraction000469931
      WBInteraction000469932
      WBInteraction000471675
      WBInteraction000474006
      WBInteraction000475296
      WBInteraction000502230
      WBInteraction000522872
      WBInteraction000539029
      WBInteraction000544144
      WBInteraction000549414
      WBInteraction000554388
      WBInteraction000555589
      WBInteraction000557094
      WBInteraction000557095
      WBInteraction000557096
      WBInteraction000557572
      WBInteraction000557617
      WBInteraction000557618
      WBInteraction000557619
      WBInteraction000557620
      WBInteraction000557621
      WBInteraction000557622
      WBInteraction000557623
      WBInteraction000557624
      WBInteraction000557625
      WBInteraction000557629
      WBInteraction000557630
      WBInteraction000557631
      WBInteraction000557632
      WBInteraction000557633
      WBInteraction000557864
      WBInteraction000560614
      WBInteraction000565264
      WBInteraction000568831
      WBInteraction000573528
      WBInteraction000581914
      WBInteraction000586465
  Map_info: Map: III Position: 0.326335 Error: 0.008197
    Positive: Positive_clone: T23G5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Sequence connection from [Ambros V]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene