WormBase Tree Display for Gene: WBGene00004049

WBGene00004049 SMap: S_parent: Sequence: Y71F9AL
  Identity: Version: 2
    Name: CGC_name: parp-1 Person_evidence: WBPerson236
      Sequence_name: Y71F9AL.18
      Molecular_name (13)
      Other_name: pme-1
        CELE_Y71F9AL.18 Accession_evidence: NDB BX284601
      Public_name: parp-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 18 Nov 2014 11:51:19 WBPerson2970 Name_change: CGC_name: parp-1
                Other_name: pme-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: parp
    Allele (323)
    Strain: WBStrain00031749
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (66)
    Paralog (4)
    Structured_description: Concise_description: parp-1 (formerly known as pme-1) encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870); PARP-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain; PARP-1 exhibits poly(ADP-ribose) activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PARP-1 is likely to be required in vivo for repairing broken DNA. Paper_evidence: WBPaper00005600
            WBPaper00025222
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables NAD+ ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; idiopathic pulmonary fibrosis; and perinatal necrotizing enterocolitis. Is an ortholog of human PARP1 (poly(ADP-ribose) polymerase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9352 Homo sapiens Paper_evidence: WBPaper00053647
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 Mar 2019 00:00:00
    Potential_model (14)
  Models_disease_asserted: WBDOannot00000650
  Molecular_info: Corresponding_CDS: Y71F9AL.18a
      Y71F9AL.18b
      Y71F9AL.18c
      Y71F9AL.18d
    Corresponding_transcript: Y71F9AL.18a.1
      Y71F9AL.18a.2
      Y71F9AL.18b.1
      Y71F9AL.18c.1
      Y71F9AL.18d.1
    Other_sequence (12)
    Associated_feature: WBsf976649
      WBsf976650
      WBsf983015
      WBsf983016
      WBsf1009424
      WBsf219077
      WBsf219078
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr2249
      Expr1023238
      Expr1031949
      Expr1161576
      Expr2014736
      Expr2032970
    Microarray_results (27)
    Expression_cluster (142)
    Interaction: WBInteraction000119071
      WBInteraction000122664
      WBInteraction000122720
      WBInteraction000122741
      WBInteraction000122774
      WBInteraction000122804
      WBInteraction000122813
      WBInteraction000123373
      WBInteraction000123697
      WBInteraction000134086
      WBInteraction000157913
      WBInteraction000158199
      WBInteraction000158206
      WBInteraction000158217
      WBInteraction000158221
      WBInteraction000158240
      WBInteraction000158249
      WBInteraction000158256
      WBInteraction000158269
      WBInteraction000158286
      WBInteraction000158302
      WBInteraction000158309
      WBInteraction000158320
      WBInteraction000158330
      WBInteraction000158341
      WBInteraction000158345
      WBInteraction000158416
      WBInteraction000158627
      WBInteraction000158628
      WBInteraction000158909
      WBInteraction000159204
      WBInteraction000159480
      WBInteraction000161032
      WBInteraction000162443
      WBInteraction000162472
      WBInteraction000162631
      WBInteraction000164436
      WBInteraction000167656
      WBInteraction000167778
      WBInteraction000169801
      WBInteraction000172967
      WBInteraction000172993
      WBInteraction000173737
      WBInteraction000174261
      WBInteraction000339626
      WBInteraction000339763
      WBInteraction000361684
      WBInteraction000542363
      WBInteraction000542364
      WBInteraction000542365
      WBInteraction000542366
      WBInteraction000549164
      WBInteraction000559680
      WBInteraction000560151
      WBInteraction000564909
      WBInteraction000573506
      WBInteraction000574801
      WBInteraction000578942
      WBInteraction000583083
  Map_info: Map: I Position: -5.30235 Error: 0.001434
    Positive: Positive_clone: Y71F9AL Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4775
        5051
    Pseudo_map_position
  Reference (24)
  Remark: Gene information and sequence connection from Serge Desnoyers. krb [020430]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene