WormBase Tree Display for Gene: WBGene00004020

WBGene00004020 SMap: S_parent: Sequence: EGAP2
  Identity: Version: 1
    Name: CGC_name: pho-1 Person_evidence: WBPerson411
      Sequence_name: EGAP2.3
      Molecular_name: EGAP2.3
        EGAP2.3.1
        CE04325
      Other_name: CELE_EGAP2.3 Accession_evidence: NDB BX284602
      Public_name: pho-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pho
    Allele (44)
    Legacy_information: [C.elegansII] ca101 : electrophoretic variant in major acidphosphatase, no other phenotype. NA1. Purified protein is homodimeric glycoprotein,55kD subunit; activity detected at luminal edge of most gut cells, but not 6 most anterior. [Beh et al. 1991; JM]
      [Beh CT, McGhee JD] ca101 leads to electrophoretic variant in major acid phosphatase, no other phenotype. NA1. Purified protein is homodimeric glycoprotein, 55kD subunit, activity detected at luminal edge of most gut cells, but not 6 most anterior.
    Strain (3)
    RNASeq_FPKM (74)
    GO_annotation: 00063393
      00063394
      00063395
      00063396
      00063397
      00063398
      00063399
      00063400
    Ortholog (27)
    Paralog (23)
    Structured_description: Concise_description: pho-1 encodes the major C. elegans intestinal acid phosphatase; PHO-1 may function redundantly with other acid phosphatases; PHO-1 intestinal expression appears to be positively regulated by CKI-1, a cyclin-dependent kinase inhibitor, and negatively regulated by POP-1, a TCF/LEF transcription factor; PHO-1 is expressed along the intestinal brush border in all gut cells except the most anterior int-1 and int-2 cells, beginning at the three-fold stage of embryogenesis. Paper_evidence: WBPaper00001454
            WBPaper00005295
            WBPaper00017091
          Curator_confirmed: WBPerson1843
          Date_last_updated: 27 Mar 2014 00:00:00
      Automated_description: Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Located in membrane raft. Expressed in intestine. Used to study obesity. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
  Models_disease_in_annotation: WBDOannot00001252
  Molecular_info: Corresponding_CDS: EGAP2.3
    Corresponding_transcript: EGAP2.3.1
    Other_sequence (29)
    Associated_feature: WBsf650050
      WBsf650051
      WBsf665523
      WBsf982352
      WBsf982353
      WBsf223018
      WBsf223019
      WBsf223020
      WBsf223021
  Experimental_info: RNAi_result (18)
    Expr_pattern: Expr3212
      Expr1027207
      Expr1031925
      Expr1147694
      Expr2014906
      Expr2033142
    Drives_construct: WBCnstr00000345
      WBCnstr00035738
    Construct_product: WBCnstr00035738
    Microarray_results (20)
    Expression_cluster (259)
    Interaction: WBInteraction000005657
      WBInteraction000118952
      WBInteraction000146163
      WBInteraction000175620
      WBInteraction000185554
      WBInteraction000186210
      WBInteraction000199622
      WBInteraction000208986
      WBInteraction000213153
      WBInteraction000213608
      WBInteraction000233943
      WBInteraction000236709
      WBInteraction000253236
      WBInteraction000255805
      WBInteraction000260225
      WBInteraction000261129
      WBInteraction000272669
      WBInteraction000275257
      WBInteraction000285333
      WBInteraction000286989
      WBInteraction000290697
      WBInteraction000301027
      WBInteraction000302148
      WBInteraction000305991
      WBInteraction000307569
      WBInteraction000308875
      WBInteraction000310748
      WBInteraction000311890
      WBInteraction000312441
      WBInteraction000315703
      WBInteraction000321299
      WBInteraction000323175
      WBInteraction000325066
      WBInteraction000325238
      WBInteraction000325732
      WBInteraction000331296
      WBInteraction000347112
      WBInteraction000350733
      WBInteraction000352426
      WBInteraction000378482
      WBInteraction000381324
      WBInteraction000381441
      WBInteraction000383447
      WBInteraction000386912
      WBInteraction000389748
      WBInteraction000396737
      WBInteraction000404327
      WBInteraction000407476
      WBInteraction000412886
      WBInteraction000415145
      WBInteraction000419924
      WBInteraction000422364
      WBInteraction000428439
      WBInteraction000431041
      WBInteraction000435387
      WBInteraction000446376
      WBInteraction000446511
      WBInteraction000448906
      WBInteraction000450040
      WBInteraction000502473
      WBInteraction000538683
      WBInteraction000538685
      WBInteraction000538686
      WBInteraction000544179
      WBInteraction000552821
      WBInteraction000564147
      WBInteraction000570987
  Map_info: Map: II Position: -1.84291 Error: 0.018889
    Positive: Positive_clone: EGAP2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7072
        7073
        7074
      Multi_point: 3635
        3636
        5004
        5035
  Reference (19)
  Remark: Data extracted from Beh et al. (1991)
    Sequence connection from [McGhee JD]
  Method: Gene