WormBase Tree Display for Gene: WBGene00004002

WBGene00004002 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: pgp-8 Person_evidence: WBPerson490
      Sequence_name: T21E8.3
      Molecular_name: T21E8.3
        T21E8.3.1
        CE31624
      Other_name: CELE_T21E8.3 Accession_evidence: NDB BX284606
      Public_name: pgp-8
    DB_info: Database: AceView gene XL480
        WormQTL gene WBGene00004002
        WormFlux gene WBGene00004002
        NDB locus_tag CELE_T21E8.3
        Panther gene CAEEL|WormBase=WBGene00004002|UniProtKB=G5EG03
          family PTHR24221
        NCBI gene 181277
        RefSeq protein NM_077410.6
        TrEMBL UniProtAcc G5EG03
        UniProt_GCRP UniProtAcc G5EG03
        OMIM gene 171050
            171060
            603201
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pgp
    Allele (100)
    Strain: WBStrain00001121
      WBStrain00032601
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (50)
    Paralog (23)
    Structured_description: Concise_description: pgp-8 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-8 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-8 activity via RNAi results in no obvious defects, the precise role of PGP-8 in C. elegans development and/or behavior is not yet known; pgp-8 promoter-gfp fusion proteins are expressed in adult head neurons. Paper_evidence: WBPaper00006421
            WBPaper00024561
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 07 Mar 2006 00:00:00
      Automated_description: Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (41)
  Molecular_info: Corresponding_CDS: T21E8.3
    Corresponding_CDS_history: T21E8.3:wp83
    Corresponding_transcript: T21E8.3.1
    Other_sequence (5)
    Associated_feature: WBsf671000
      WBsf237902
  Experimental_info: RNAi_result: WBRNAi00053751 Inferred_automatically: RNAi_primary
      WBRNAi00035767 Inferred_automatically: RNAi_primary
      WBRNAi00077358 Inferred_automatically: RNAi_primary
      WBRNAi00070100 Inferred_automatically: RNAi_primary
      WBRNAi00018984 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1650
      Expr3333
      Expr3334
      Expr1017136
      Expr1157298
      Expr2014875
      Expr2033110
    Drives_construct: WBCnstr00002004
      WBCnstr00011329
      WBCnstr00011330
      WBCnstr00035748
    Construct_product: WBCnstr00016458
      WBCnstr00035748
    Microarray_results (18)
    Expression_cluster (206)
    Interaction: WBInteraction000120511
      WBInteraction000124070
      WBInteraction000136426
      WBInteraction000138940
      WBInteraction000139887
      WBInteraction000144968
      WBInteraction000145668
      WBInteraction000146988
      WBInteraction000147171
      WBInteraction000147973
      WBInteraction000153328
      WBInteraction000156560
      WBInteraction000156628
      WBInteraction000156704
      WBInteraction000163762
      WBInteraction000168254
      WBInteraction000168797
      WBInteraction000170553
      WBInteraction000176670
      WBInteraction000177967
      WBInteraction000178542
      WBInteraction000179291
      WBInteraction000180094
      WBInteraction000180878
      WBInteraction000183636
      WBInteraction000184348
      WBInteraction000189321
      WBInteraction000190867
      WBInteraction000190949
      WBInteraction000191229
      WBInteraction000192199
      WBInteraction000194384
      WBInteraction000195062
      WBInteraction000200945
      WBInteraction000201976
      WBInteraction000202060
      WBInteraction000203227
      WBInteraction000206364
      WBInteraction000207336
      WBInteraction000207459
      WBInteraction000209142
      WBInteraction000211953
      WBInteraction000212427
      WBInteraction000213139
      WBInteraction000213732
      WBInteraction000214413
      WBInteraction000214801
      WBInteraction000216060
      WBInteraction000219479
      WBInteraction000220585
      WBInteraction000223385
      WBInteraction000230264
      WBInteraction000231633
      WBInteraction000232265
      WBInteraction000232759
      WBInteraction000233015
      WBInteraction000245192
      WBInteraction000246957
      WBInteraction000248295
      WBInteraction000248949
      WBInteraction000248950
      WBInteraction000251439
      WBInteraction000253111
      WBInteraction000255376
      WBInteraction000256449
      WBInteraction000262305
      WBInteraction000262997
      WBInteraction000268293
      WBInteraction000274884
      WBInteraction000280075
      WBInteraction000285450
      WBInteraction000285900
      WBInteraction000291556
      WBInteraction000293503
      WBInteraction000298221
      WBInteraction000303707
      WBInteraction000303884
      WBInteraction000305216
      WBInteraction000306081
      WBInteraction000311073
      WBInteraction000311256
      WBInteraction000311471
      WBInteraction000313645
      WBInteraction000316380
      WBInteraction000318854
      WBInteraction000321164
      WBInteraction000322731
      WBInteraction000326325
      WBInteraction000331788
      WBInteraction000334911
      WBInteraction000340563
      WBInteraction000340658
      WBInteraction000341966
      WBInteraction000341974
      WBInteraction000356587
      WBInteraction000363162
      WBInteraction000363202
      WBInteraction000363624
      WBInteraction000365423
      WBInteraction000367671
      WBInteraction000368585
      WBInteraction000371279
      WBInteraction000374107
      WBInteraction000376235
      WBInteraction000381331
      WBInteraction000382482
      WBInteraction000397877
      WBInteraction000399784
      WBInteraction000402294
      WBInteraction000403028
      WBInteraction000403123
      WBInteraction000404637
      WBInteraction000407221
      WBInteraction000413013
      WBInteraction000417565
      WBInteraction000420934
      WBInteraction000420953
      WBInteraction000421225
      WBInteraction000423090
      WBInteraction000423097
      WBInteraction000428699
      WBInteraction000432502
      WBInteraction000432698
      WBInteraction000438136
      WBInteraction000450347
      WBInteraction000450613
      WBInteraction000457468
      WBInteraction000459097
      WBInteraction000459385
      WBInteraction000463233
      WBInteraction000466394
      WBInteraction000469794
      WBInteraction000580247
  Map_info (3)
  Reference: WBPaper00006402
    WBPaper00006421
    WBPaper00028970
    WBPaper00031023
    WBPaper00035429
    WBPaper00038491
    WBPaper00046184
    WBPaper00055090
    WBPaper00062515
    WBPaper00064375
  Remark: Sequence connection from [Sheps JA, Baillie DL] [040902 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene