WormBase Tree Display for Gene: WBGene00003997
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| WBGene00003997 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-3 | Person_evidence | WBPerson490 | |||||
| Sequence_name | ZK455.7 | ||||||||
| Molecular_name | ZK455.7 | ||||||||
| ZK455.7.1 | |||||||||
| CE03818 | |||||||||
| Other_name | cepgpC | Accession_evidence | EMBL | X65055 | |||||
| CELE_ZK455.7 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pgp-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (77) | |||||||||
| Legacy_information | [C.elegansII] pk18 : deletion derived from pk30tci, increased sensitivity to colchicine and to chloroquine; gross phenotype WT. Cloned: encodes 1254 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins. Transcripts present throughout development; pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-3 detected in apical membranes of gut and of excretory cell. [Broeks et al. 1995; NL] | ||||||||
| Strain | WBStrain00028887 | ||||||||
| WBStrain00028888 | |||||||||
| WBStrain00028891 | |||||||||
| WBStrain00033025 | |||||||||
| WBStrain00037266 | |||||||||
| WBStrain00004731 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (71) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells. | Paper_evidence | WBPaper00002180 | |||||
| WBPaper00003366 | |||||||||
| WBPaper00003925 | |||||||||
| WBPaper00004651 | |||||||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Apr 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Expressed in excretory canal; excretory cell; intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info | Corresponding_CDS | ZK455.7 | |||||||
| Corresponding_transcript | ZK455.7.1 | ||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf1006975 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00059437 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022018 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014821 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001488 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00002142 | ||||||||
| WBCnstr00010331 | |||||||||
| WBCnstr00011338 | |||||||||
| WBCnstr00011339 | |||||||||
| WBCnstr00012125 | |||||||||
| WBCnstr00012126 | |||||||||
| WBCnstr00012634 | |||||||||
| WBCnstr00015310 | |||||||||
| WBCnstr00035753 | |||||||||
| Construct_product | WBCnstr00012634 | ||||||||
| WBCnstr00014565 | |||||||||
| WBCnstr00014566 | |||||||||
| WBCnstr00035753 | |||||||||
| Antibody | WBAntibody00000095 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (180) | |||||||||
| Interaction | WBInteraction000126398 | ||||||||
| WBInteraction000138051 | |||||||||
| WBInteraction000138053 | |||||||||
| WBInteraction000143144 | |||||||||
| WBInteraction000184977 | |||||||||
| WBInteraction000215689 | |||||||||
| WBInteraction000215690 | |||||||||
| WBInteraction000216316 | |||||||||
| WBInteraction000231449 | |||||||||
| WBInteraction000238579 | |||||||||
| WBInteraction000246779 | |||||||||
| WBInteraction000250489 | |||||||||
| WBInteraction000298883 | |||||||||
| WBInteraction000327365 | |||||||||
| WBInteraction000353386 | |||||||||
| WBInteraction000361338 | |||||||||
| WBInteraction000364168 | |||||||||
| WBInteraction000367809 | |||||||||
| WBInteraction000369663 | |||||||||
| WBInteraction000392908 | |||||||||
| WBInteraction000394423 | |||||||||
| WBInteraction000417860 | |||||||||
| WBInteraction000426948 | |||||||||
| WBInteraction000431488 | |||||||||
| WBInteraction000434444 | |||||||||
| WBInteraction000451557 | |||||||||
| WBInteraction000467095 | |||||||||
| WBInteraction000474588 | |||||||||
| WBInteraction000504105 | |||||||||
| WBInteraction000520631 | |||||||||
| WBInteraction000524442 | |||||||||
| WBInteraction000536776 | |||||||||
| WBInteraction000557017 | |||||||||
| WBInteraction000580243 | |||||||||
| Map_info (3) | |||||||||
| Reference (46) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
