WormBase Tree Display for Gene: WBGene00003914

WBGene00003914 Evidence: Person_evidence: WBPerson2626
      WBPerson1106
  SMap: S_parent: Sequence: F49E8
  Identity: Version: 2
    Name: CGC_name: pam-1
      Sequence_name: F49E8.3
      Molecular_name: F49E8.3a
        F49E8.3a.1
        CE10790
        F49E8.3b
        CE37649
        F49E8.3a.2
        F49E8.3a.3
        F49E8.3b.1
      Other_name: scu-1 Paper_evidence: WBPaper00028560
        CELE_F49E8.3 Accession_evidence: NDB BX284604
      Public_name: pam-1
    DB_info: Database: WormQTL gene WBGene00003914
        WormFlux gene WBGene00003914
        NDB locus_tag CELE_F49E8.3
        Panther gene CAEEL|WormBase=WBGene00003914|UniProtKB=Q4TT88
          family PTHR11533
        NCBI gene 177528
        RefSeq protein NM_001028039.3
            NM_001392330.1
        KEGG KEGG_id 3.4.11.14
        NemaPath KEGG_id 3.4.11.14
        SwissProt UniProtAcc Q4TT88
        UniProt_GCRP UniProtAcc Q4TT88
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 19 Oct 2006 10:23:17 WBPerson2970 Name_change: Other_name: scu-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pam
    Allele (89)
    Strain: WBStrain00031440
    RNASeq_FPKM (74)
    GO_annotation (52)
    Contained_in_operon: CEOP4228
      CEOP4618
    Ortholog (68)
    Paralog (13)
    Structured_description: Concise_description: pam-1 encodes a metalloprotease that is the C. elegans puromycin-sensitive aminopeptidase (PSA) ortholog; in the one-cell embryo, PAM-1 is required for timely exit from meiosis II proper centrosome positioning, proper localization of polarity and cell fate determinants, and formation of the anteroposterior axis; genetic studies indicate that cyb-3, which encodes a B-type cyclin, is required for pam-1(lf) meiotic exit defects, suggesting that CYB-3 activity is regulated by PAM-1, directly or indirectly, in the early embryo; a pam-1::gfp reporter fusion is expressed in embryos, larvae, and adults; in larvae and adults, expression is particularly notable in the posterior intestine and amphid sensory neurons; in males, expression is also seen in neurons in the developing and mature male tail; in vitro, PAM-1 exhibits metal-dependent aminopeptidase activity, hydrolyzing the N-terminal amino acid from various peptide substrates. Paper_evidence: WBPaper00006165
            WBPaper00028560
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Nov 2007 00:00:00
      Automated_description: Enables metalloaminopeptidase activity. Involved in several processes, including exit from meiosis; first cell cycle pseudocleavage; and regulation of reproductive process. Located in condensed chromosome; cytoplasm; and mitotic spindle pole. Expressed in amphid process; intestine; male-specific anatomical entity; nerve ring; and tail neurons. Is an ortholog of human NPEPPS (aminopeptidase puromycin sensitive). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F49E8.3a
      F49E8.3b
    Corresponding_CDS_history: F49E8.3:wp143
    Corresponding_transcript: F49E8.3a.1
      F49E8.3a.2
      F49E8.3a.3
      F49E8.3b.1
    Other_sequence (59)
    Associated_feature: WBsf997007
      WBsf230289
      WBsf230290
      WBsf230291
  Experimental_info: RNAi_result (7)
    Expr_pattern: Chronogram871
      Chronogram872
      Chronogram1758
      Expr2635
      Expr9077
      Expr1016847
      Expr1031847
      Expr1151700
      Expr2014716
      Expr2032950
    Drives_construct: WBCnstr00010880
      WBCnstr00035799
    Construct_product: WBCnstr00010880
      WBCnstr00035799
    Antibody: WBAntibody00002146
    Microarray_results (27)
    Expression_cluster (131)
    Interaction: WBInteraction000039573
      WBInteraction000043277
      WBInteraction000122690
      WBInteraction000122803
      WBInteraction000123559
      WBInteraction000183007
      WBInteraction000183008
      WBInteraction000186765
      WBInteraction000187968
      WBInteraction000189902
      WBInteraction000201213
      WBInteraction000202947
      WBInteraction000210105
      WBInteraction000213230
      WBInteraction000222466
      WBInteraction000222917
      WBInteraction000226282
      WBInteraction000235646
      WBInteraction000241434
      WBInteraction000253384
      WBInteraction000256649
      WBInteraction000267347
      WBInteraction000269931
      WBInteraction000276113
      WBInteraction000280862
      WBInteraction000280863
      WBInteraction000282450
      WBInteraction000290205
      WBInteraction000290754
      WBInteraction000292282
      WBInteraction000296102
      WBInteraction000300979
      WBInteraction000303792
      WBInteraction000311241
      WBInteraction000318292
      WBInteraction000318583
      WBInteraction000329402
      WBInteraction000344333
      WBInteraction000351267
      WBInteraction000355718
      WBInteraction000358448
      WBInteraction000371843
      WBInteraction000387431
      WBInteraction000387432
      WBInteraction000400896
      WBInteraction000401245
      WBInteraction000403857
      WBInteraction000404907
      WBInteraction000407798
      WBInteraction000409131
      WBInteraction000417451
      WBInteraction000426690
      WBInteraction000428341
      WBInteraction000429610
      WBInteraction000435614
      WBInteraction000442416
      WBInteraction000445704
      WBInteraction000447525
      WBInteraction000450891
      WBInteraction000451906
      WBInteraction000455104
      WBInteraction000457114
      WBInteraction000462792
      WBInteraction000463433
      WBInteraction000464801
      WBInteraction000466563
      WBInteraction000467190
      WBInteraction000467598
      WBInteraction000469529
      WBInteraction000469933
      WBInteraction000470863
      WBInteraction000473280
      WBInteraction000473355
      WBInteraction000474103
      WBInteraction000475206
      WBInteraction000502654
      WBInteraction000502655
      WBInteraction000502656
      WBInteraction000502657
      WBInteraction000541573
      WBInteraction000541574
      WBInteraction000541575
      WBInteraction000541576
      WBInteraction000543391
      WBInteraction000549631
      WBInteraction000551691
      WBInteraction000554015
      WBInteraction000557890
      WBInteraction000563002
      WBInteraction000568793
      WBInteraction000580216
      WBInteraction000582731
  Map_info: Map: IV Position: 3.34579 Error: 0.001269
    Positive: Positive_clone: F49E8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4190
        4563
    Pseudo_map_position
  Reference (26)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene