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WormBase Tree Display for Gene: WBGene00003858

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Name Class

WBGene00003858EvidencePaper_evidenceWBPaper00002840
SMapS_parentSequenceK04G7
IdentityVersion1
NameCGC_nameogt-1Person_evidenceWBPerson346
Sequence_nameK04G7.3
Molecular_nameK04G7.3a
K04G7.3a.1
CE25042
K04G7.3b
CE39588
K04G7.3b.1
Other_nameC. elegans OGTPaper_evidenceWBPaper00002840
OgtPaper_evidenceWBPaper00046676
CELE_K04G7.3Accession_evidenceNDBBX284603
Public_nameogt-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classogt
Allele (120)
Possibly_affected_byWBVar02152826
WBVar02157221
WBVar02158442
WBVar02158444
WBVar02158445
Strain (16)
RNASeq_FPKM (74)
GO_annotation (30)
Ortholog (37)
ParalogWBGene00000244Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003885Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00017983Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00018175Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021444Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021613Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00043992Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization.Paper_evidenceWBPaper00002840
WBPaper00026663
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated03 Aug 2006 00:00:00
Automated_descriptionEnables protein N-acetylglucosaminyltransferase activity; protein O-acetylglucosaminyltransferase activity; and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and lipid storage. Located in nucleus and perinuclear region of cytoplasm. Expressed in several structures, including hypodermal cell; intestine; neurons; and somatic cell. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in aortic valve stenosis and non-syndromic X-linked intellectual disability 106. Is an ortholog of human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9351Homo sapiensPaper_evidenceWBPaper00058670
Curator_confirmedWBPerson324
Date_last_updated19 May 2021 00:00:00
DOID:9352Homo sapiensPaper_evidenceWBPaper00028382
WBPaper00026663
Curator_confirmedWBPerson324
Date_last_updated03 Feb 2020 00:00:00
Potential_modelDOID:0080240Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8127)
DOID:1712Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8127)
Models_disease_assertedWBDOannot00000733
WBDOannot00000734
WBDOannot00000915
WBDOannot00000916
Molecular_infoCorresponding_CDSK04G7.3a
K04G7.3b
Corresponding_CDS_historyK04G7.3:wp153
Corresponding_transcriptK04G7.3a.1
K04G7.3b.1
Other_sequence (62)
Associated_feature (11)
Experimental_infoRNAi_result (11)
Expr_patternExpr1469
Expr12076
Expr12077
Expr14785
Expr15904
Expr1011594
Expr1031818
Expr1153651
Expr2014617
Expr2032850
Drives_constructWBCnstr00020059
WBCnstr00035826
WBCnstr00042812
Construct_productWBCnstr00020059
WBCnstr00035826
WBCnstr00042812
WBCnstr00042813
WBCnstr00042814
WBCnstr00042815
WBCnstr00042816
WBCnstr00042817
WBCnstr00042818
Regulate_expr_clusterWBPaper00046083:ogt-1(ok1474)_OP50_downregulated
WBPaper00046083:ogt-1(ok1474)_OP50_upregulated
AntibodyWBAntibody00000148
Microarray_results (25)
Expression_cluster (139)
InteractionWBInteraction000005201
WBInteraction000007333
WBInteraction000007409
WBInteraction000031458
WBInteraction000162439
WBInteraction000167467
WBInteraction000167485
WBInteraction000173376
WBInteraction000173381
WBInteraction000173384
WBInteraction000173433
WBInteraction000173590
WBInteraction000173591
WBInteraction000173592
WBInteraction000173593
WBInteraction000176179
WBInteraction000179336
WBInteraction000196664
WBInteraction000226294
WBInteraction000250416
WBInteraction000255958
WBInteraction000304965
WBInteraction000304966
WBInteraction000337276
WBInteraction000398481
WBInteraction000401512
WBInteraction000416713
WBInteraction000444966
WBInteraction000504353
WBInteraction000518025
WBInteraction000518026
WBInteraction000518027
WBInteraction000518031
WBInteraction000518543
WBInteraction000519024
WBInteraction000524589
WBInteraction000540384
WBInteraction000549643
WBInteraction000550349
WBInteraction000558415
WBInteraction000559359
WBInteraction000559810
WBInteraction000560082
WBInteraction000560346
WBInteraction000560347
WBInteraction000560348
WBInteraction000562908
WBInteraction000564846
WBInteraction000566141
WBInteraction000567636
WBInteraction000568920
WBInteraction000574804
WBInteraction000578946
WBInteraction000578947
WBInteraction000579086
WBInteraction000580211
WBInteraction000584402
WBInteraction000524588
Map_info (4)
Reference (51)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene