WormBase Tree Display for Gene: WBGene00003214

WBGene00003214 SMap: S_parent: Sequence: C05D11
  Identity: Version: 1
    Name: CGC_name: mel-32 Person_evidence: WBPerson314
      Sequence_name: C05D11.11
      Molecular_name: C05D11.11a
        C05D11.11a.1
        CE01130
        C05D11.11b
        CE29661
        C05D11.11a.2
        C05D11.11a.3
        C05D11.11b.1
      Other_name: CELE_C05D11.11 Accession_evidence: NDB BX284603
      Public_name: mel-32
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mel
    Allele (60)
    Legacy_information: [Vatcher GP] homozygotes develope into adults that lay egg which do not hatch.
      [Schnabel H] other name: emb-25 NA18
    Complementation_data: [Vatcher GP] complements let-713 (s2449), let-721(s2447), let-725(s2454), let-728(2573), let-747(s2456), let-756(s2613), let-767(s2464).
    Strain: WBStrain00001425
      WBStrain00000962
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog (42)
    Structured_description: Concise_description: mel-32 encodes a serine hydroxymethyltransferase; by homology, MEL-32 is predicted to catalyze the biochemical reaction that converts serine to glycine and in the process transfers a methyl group to tetrahydrofolate and, thus, into the one-carbon pool used for a variety of cellular metabolic processes; in C. elegans MEL-32 activity is required maternally for embryonic development past the 100-cell stage. Paper_evidence (2)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 10 Jan 2008 00:00:00
      Automated_description: Predicted to enable several functions, including glycine hydroxymethyltransferase activity; ion binding activity; and nucleic acid binding activity. Involved in embryo development. Located in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human SHMT1 (serine hydroxymethyltransferase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10850)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10850)
  Molecular_info: Corresponding_CDS: C05D11.11a
      C05D11.11b
    Corresponding_transcript: C05D11.11a.1
      C05D11.11a.2
      C05D11.11a.3
      C05D11.11b.1
    Other_sequence (140)
    Associated_feature: WBsf651128
      WBsf666995
      WBsf666996
      WBsf992765
      WBsf992766
      WBsf226823
      WBsf226824
      WBsf226825
  Experimental_info: RNAi_result (11)
    Expr_pattern: Chronogram490
      Expr5167
      Expr1024771
      Expr1031517
      Expr1143823
      Expr2013519
      Expr2031753
    Drives_construct: WBCnstr00002309
      WBCnstr00036183
    Construct_product: WBCnstr00036183
    Microarray_results (30)
    Expression_cluster (200)
    Interaction: WBInteraction000031216
      WBInteraction000038232
      WBInteraction000040324
      WBInteraction000043520
      WBInteraction000044518
      WBInteraction000044519
      WBInteraction000046991
      WBInteraction000047502
      WBInteraction000047791
      WBInteraction000111303
      WBInteraction000112731
      WBInteraction000139035
      WBInteraction000140723
      WBInteraction000149398
      WBInteraction000154188
      WBInteraction000159668
      WBInteraction000161128
      WBInteraction000166802
      WBInteraction000168472
      WBInteraction000170987
      WBInteraction000187169
      WBInteraction000189992
      WBInteraction000199265
      WBInteraction000202574
      WBInteraction000215930
      WBInteraction000217991
      WBInteraction000218681
      WBInteraction000229816
      WBInteraction000230365
      WBInteraction000231093
      WBInteraction000238191
      WBInteraction000245616
      WBInteraction000253370
      WBInteraction000256552
      WBInteraction000259708
      WBInteraction000269015
      WBInteraction000274639
      WBInteraction000274640
      WBInteraction000280032
      WBInteraction000280849
      WBInteraction000282249
      WBInteraction000282735
      WBInteraction000290235
      WBInteraction000294932
      WBInteraction000299155
      WBInteraction000307280
      WBInteraction000309218
      WBInteraction000310731
      WBInteraction000313642
      WBInteraction000316055
      WBInteraction000325070
      WBInteraction000326829
      WBInteraction000337612
      WBInteraction000346919
      WBInteraction000349079
      WBInteraction000356211
      WBInteraction000357943
      WBInteraction000361315
      WBInteraction000363442
      WBInteraction000364526
      WBInteraction000368764
      WBInteraction000368765
      WBInteraction000369610
      WBInteraction000370993
      WBInteraction000371311
      WBInteraction000374630
      WBInteraction000377490
      WBInteraction000380351
      WBInteraction000386636
      WBInteraction000395621
      WBInteraction000397911
      WBInteraction000406192
      WBInteraction000429570
      WBInteraction000429721
      WBInteraction000434498
      WBInteraction000437748
      WBInteraction000439994
      WBInteraction000440769
      WBInteraction000443485
      WBInteraction000451408
      WBInteraction000455538
      WBInteraction000455931
      WBInteraction000456626
      WBInteraction000458508
      WBInteraction000459595
      WBInteraction000461347
      WBInteraction000462145
      WBInteraction000463301
      WBInteraction000463436
      WBInteraction000463732
      WBInteraction000463926
      WBInteraction000466452
      WBInteraction000466852
      WBInteraction000467029
      WBInteraction000468153
      WBInteraction000468307
      WBInteraction000470055
      WBInteraction000470075
      WBInteraction000470547
      WBInteraction000470999
      WBInteraction000471495
      WBInteraction000471556
      WBInteraction000472882
      WBInteraction000473820
      WBInteraction000475352
      WBInteraction000539876
      WBInteraction000549577
      WBInteraction000550927
      WBInteraction000551728
      WBInteraction000554020
      WBInteraction000562095
      WBInteraction000564051
      WBInteraction000567586
      WBInteraction000572407
      WBInteraction000573995
      WBInteraction000574549
      WBInteraction000577432
      WBInteraction000577643
      WBInteraction000580155
      WBInteraction000583046
      WBInteraction000586137
  Map_info: Map: III Position: -1.27054 Error: 0.001406
    Well_ordered
    Positive: Inside_rearr: sDf127
        sDf125
        sDp3
      Positive_clone: C05D11 Inferred_automatically: From sequence, transcript, pseudogene data
        pC05.11
    Negative: Outside_rearr: sDf121
    Mapping_data: Pos_neg_data: 9286
        9287
        9288
        9289
  Reference (25)
  Remark: pC05.11 is a subclone of C05D11 containing only ORF 11. It partially rescues the Mel phenotype.
    Sequence connections updated by Darin Blasiar Jan, 2002
  Method: Gene