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WormBase Tree Display for Gene: WBGene00003151

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Name Class

WBGene00003151SMapS_parentSequenceW09C2
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classmca
Allele (95)
Legacy_information[Kraev A] Originally identified by similarity to mammalian PMCA family proteins in Genome Project data, mca-1 was expressed in insect cells and shown to have the predicted activity: aspartyl-phosphate formation in the presence of calcium, like mammalian counterparts, has a calmodulin-binding domain at the C-terminus and actually binds human calmodulin in a standard assay. Two other related sequences identified in the genomic sequencing data "in progress" and cDNAs finished by direct RT-PCR product sequencing. Mca-3 shows the highest sequence similarity to the mammalian analogues (77% on aminoacid). All three mca sequences have calmodulin-binding domains at the same location as their mammalian counterparts and the same predicted trans-membrane topology
StrainWBStrain00037024
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (40)
Paralog (14)
Structured_descriptionConcise_descriptionmca-1 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-1 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; when expressed in insect cells, MCA-1 exhibits calcium-pumping ATPase activity and binding to human calmodulin; large-scale RNAi screens indicate that mca-1 activity is required for normal coordinated locomotion and rates of growth; an mca-1::gfp reporter fusion is expressed solely in the excretory canal.Paper_evidenceWBPaper00003407
WBPaper00029172
Curator_confirmedWBPerson1843
Date_last_updated30 Apr 2007 00:00:00
Automated_descriptionEnables P-type calcium transporter activity and calmodulin binding activity. Involved in calcium ion transport and intracellular calcium ion homeostasis. Located in membrane. Expressed in excretory canal.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSW09C2.3a
W09C2.3b
W09C2.3c
W09C2.3d
Corresponding_CDS_historyW09C2.3:wp92
Corresponding_transcriptW09C2.3a.1
W09C2.3b.1
W09C2.3c.1
W09C2.3d.1
Other_sequence (51)
Associated_feature (12)
Experimental_infoRNAi_resultWBRNAi00088616Inferred_automaticallyRNAi_primary
WBRNAi00026522Inferred_automaticallyRNAi_primary
WBRNAi00019742Inferred_automaticallyRNAi_primary
WBRNAi00000551Inferred_automaticallyRNAi_primary
WBRNAi00088723Inferred_automaticallyRNAi_primary
WBRNAi00055018Inferred_automaticallyRNAi_primary
WBRNAi00027503Inferred_automaticallyRNAi_primary
WBRNAi00026523Inferred_automaticallyRNAi_primary
Expr_patternExpr8318
Expr1025870
Expr1031487
Expr1158554
Expr2013442
Expr2031676
Drives_constructWBCnstr00008393
WBCnstr00013258
WBCnstr00036215
Construct_productWBCnstr00036215
Microarray_results (38)
Expression_cluster (173)
InteractionWBInteraction000113661
WBInteraction000115141
WBInteraction000134068
WBInteraction000139568
WBInteraction000139592
WBInteraction000139610
WBInteraction000141220
WBInteraction000159908
WBInteraction000177930
WBInteraction000189316
WBInteraction000195102
WBInteraction000195586
WBInteraction000214829
WBInteraction000219568
WBInteraction000219570
WBInteraction000237776
WBInteraction000238367
WBInteraction000238434
WBInteraction000244778
WBInteraction000247764
WBInteraction000249363
WBInteraction000255368
WBInteraction000255872
WBInteraction000255972
WBInteraction000255976
WBInteraction000271437
WBInteraction000271944
WBInteraction000273909
WBInteraction000276891
WBInteraction000278548
WBInteraction000278550
WBInteraction000286757
WBInteraction000298828
WBInteraction000306713
WBInteraction000313195
WBInteraction000314283
WBInteraction000320223
WBInteraction000322956
WBInteraction000333877
WBInteraction000334570
WBInteraction000337542
WBInteraction000341514
WBInteraction000342530
WBInteraction000346739
WBInteraction000352829
WBInteraction000358554
WBInteraction000362003
WBInteraction000362195
WBInteraction000386929
WBInteraction000391788
WBInteraction000395011
WBInteraction000400244
WBInteraction000405699
WBInteraction000420989
WBInteraction000437124
WBInteraction000440134
WBInteraction000442423
WBInteraction000463438
WBInteraction000463455
WBInteraction000463720
WBInteraction000464134
WBInteraction000467435
WBInteraction000471418
WBInteraction000471726
WBInteraction000472799
WBInteraction000473341
WBInteraction000540493
WBInteraction000563162
WBInteraction000567228
WBInteraction000576695
WBInteraction000580146
WBInteraction000585940
Map_infoMapIVPosition4.34306Error0.000339
PositivePositive_cloneW09C2Author_evidenceKraev A
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00003407
WBPaper00011802
WBPaper00015567
WBPaper00038491
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene