WormBase Tree Display for Gene: WBGene00003020

WBGene00003020 SMap: S_parent: Sequence: C32F10
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Allele (104)
    Legacy_information: n745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)).
      See also n373, n745
      [C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS]
    Strain (17)
    Component_of_genotype: WBGenotype00000009
    RNASeq_FPKM (74)
    GO_annotation (50)
    Ortholog (43)
    Structured_description: Concise_description: lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, loss of lin-35 activity results in enhanced RNA interference; lin-35 activity is also required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells. Paper_evidence: WBPaper00003329
            WBPaper00004635
            WBPaper00005137
            WBPaper00005931
            WBPaper00024215
            WBPaper00024320
            WBPaper00024322
            WBPaper00024692
            WBPaper00027135
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 05 May 2009 00:00:00
      Automated_description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1059 Homo sapiens Paper_evidence: WBPaper00024322
          Accession_evidence: OMIM 309580
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 Apr 2013 00:00:00
    Potential_model (16)
    Disease_relevance: Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. Homo sapiens Paper_evidence: WBPaper00024322
            WBPaper00024692
            WBPaper00003646
          Curator_confirmed: WBPerson324
          Date_last_updated: 23 Apr 2013 00:00:00
  Models_disease_asserted: WBDOannot00000614
    WBDOannot00001021
  Molecular_info: Corresponding_CDS: C32F10.2
    Corresponding_transcript: C32F10.2.1
    Associated_feature: WBsf643315
      WBsf643316
      WBsf656335
      WBsf656336
      WBsf656337
      WBsf656338
      WBsf983774
      WBsf217712
    Gene_product_binds (376)
    Transcription_factor: WBTranscriptionFactor000270
  Experimental_info: RNAi_result (78)
    Expr_pattern: Chronogram622
      Expr1291
      Expr3128
      Expr1015789
      Expr1031411
      Expr1145718
      Expr2013177
      Expr2031409
    Drives_construct: WBCnstr00004066
      WBCnstr00006281
      WBCnstr00011156
      WBCnstr00017294
      WBCnstr00036281
    Construct_product: WBCnstr00006281
      WBCnstr00011156
      WBCnstr00017287
      WBCnstr00017294
      WBCnstr00017295
      WBCnstr00017296
      WBCnstr00021077
      WBCnstr00021078
      WBCnstr00021079
      WBCnstr00036281
    Regulate_expr_cluster (16)
    Antibody: WBAntibody00000200
      WBAntibody00001176
      WBAntibody00003008
      WBAntibody00003009
    Microarray_results (20)
    Expression_cluster (156)
    Interaction: WBInteraction000000756
      WBInteraction000001486
      WBInteraction000001596
      WBInteraction000001597
      WBInteraction000002135
      WBInteraction000002171
      WBInteraction000002420
      WBInteraction000002933
      WBInteraction000003028
      WBInteraction000003055
      WBInteraction000003064
      WBInteraction000003065
      WBInteraction000003930
      WBInteraction000004124
      WBInteraction000004842
      WBInteraction000004905
      WBInteraction000004906
      WBInteraction000004907
      WBInteraction000004908
      WBInteraction000005077
      WBInteraction000005078
      WBInteraction000005079
      WBInteraction000005156
      WBInteraction000005231
      WBInteraction000005456
      WBInteraction000005457
      WBInteraction000005740
      WBInteraction000006115
      WBInteraction000006178
      WBInteraction000006649
      WBInteraction000007198
      WBInteraction000007287
      WBInteraction000007522
      WBInteraction000007727
      WBInteraction000007774
      WBInteraction000008261
      WBInteraction000008262
      WBInteraction000008263
      WBInteraction000008264
      WBInteraction000008265
      WBInteraction000008266
      WBInteraction000008270
      WBInteraction000008274
      WBInteraction000008278
      WBInteraction000008281
      WBInteraction000008285
      WBInteraction000008289
      WBInteraction000008293
      WBInteraction000008297
      WBInteraction000008301
      WBInteraction000008305
      WBInteraction000008309
      WBInteraction000008313
      WBInteraction000008317
      WBInteraction000008321
      WBInteraction000008325
      WBInteraction000008329
      WBInteraction000008333
      WBInteraction000008337
      WBInteraction000008340
      WBInteraction000008344
      WBInteraction000008347
      WBInteraction000008351
      WBInteraction000008354
      WBInteraction000008357
      WBInteraction000008361
      WBInteraction000008365
      WBInteraction000008369
      WBInteraction000008373
      WBInteraction000008376
      WBInteraction000008380
      WBInteraction000008384
      WBInteraction000008388
      WBInteraction000008392
      WBInteraction000008396
      WBInteraction000008400
      WBInteraction000008404
      WBInteraction000008408
      WBInteraction000008412
      WBInteraction000008416
      WBInteraction000008420
      WBInteraction000008424
      WBInteraction000008428
      WBInteraction000008432
      WBInteraction000008436
      WBInteraction000008440
      WBInteraction000008444
      WBInteraction000008448
      WBInteraction000008452
      WBInteraction000008456
      WBInteraction000008460
      WBInteraction000008464
      WBInteraction000008476
      WBInteraction000008477
      WBInteraction000008478
      WBInteraction000008479
      WBInteraction000008480
      WBInteraction000008486
      WBInteraction000008622
      WBInteraction000008678
      WBInteraction000008679
      WBInteraction000008680
      WBInteraction000008803
      WBInteraction000008809
      WBInteraction000008853
      WBInteraction000008854
      WBInteraction000008855
      WBInteraction000008856
      WBInteraction000008857
      WBInteraction000008863
      WBInteraction000008885
      WBInteraction000008917
      WBInteraction000008918
      WBInteraction000008919
      WBInteraction000009041
      WBInteraction000009042
      WBInteraction000009043
      WBInteraction000009086
      WBInteraction000009566
      WBInteraction000009633
      WBInteraction000009688
      WBInteraction000009906
      WBInteraction000028335
      WBInteraction000028604
      WBInteraction000028625
      WBInteraction000028864
      WBInteraction000029078
      WBInteraction000030026
      WBInteraction000030210
      WBInteraction000031088
      WBInteraction000050642
      WBInteraction000050655
      WBInteraction000050757
      WBInteraction000050758
      WBInteraction000051553
      WBInteraction000051776
      WBInteraction000052714
      WBInteraction000052715
      WBInteraction000052773
      WBInteraction000117735
      WBInteraction000118226
      WBInteraction000120128
      WBInteraction000121246
      WBInteraction000122725
      WBInteraction000122734
      WBInteraction000122735
      WBInteraction000122736
      WBInteraction000122737
      WBInteraction000122738
      WBInteraction000126225
      WBInteraction000126627
      WBInteraction000126855
      WBInteraction000127075
      WBInteraction000127076
      WBInteraction000133382
      WBInteraction000133642
      WBInteraction000136147
      WBInteraction000150174
      WBInteraction000150175
      WBInteraction000150176
      WBInteraction000150177
      WBInteraction000150178
      WBInteraction000150179
      WBInteraction000150180
      WBInteraction000151079
      WBInteraction000159781
      WBInteraction000160280
      WBInteraction000161830
      WBInteraction000162405
      WBInteraction000162406
      WBInteraction000162407
      WBInteraction000162408
      WBInteraction000162943
      WBInteraction000162944
      WBInteraction000165501
      WBInteraction000165987
      WBInteraction000165988
      WBInteraction000165989
      WBInteraction000165990
      WBInteraction000166005
      WBInteraction000166457
      WBInteraction000167354
      WBInteraction000169471
      WBInteraction000171820
      WBInteraction000173505
      WBInteraction000175524
      WBInteraction000175525
      WBInteraction000217961
      WBInteraction000222892
      WBInteraction000233815
      WBInteraction000237802
      WBInteraction000272474
      WBInteraction000297260
      WBInteraction000306838
      WBInteraction000318940
      WBInteraction000319932
      WBInteraction000342096
      WBInteraction000360353
      WBInteraction000360614
      WBInteraction000361534
      WBInteraction000365376
      WBInteraction000430333
      WBInteraction000430859
      WBInteraction000436378
      WBInteraction000454923
      WBInteraction000461758
      WBInteraction000500534
      WBInteraction000500539
      WBInteraction000500544
      WBInteraction000500549
      WBInteraction000500554
      WBInteraction000500559
      WBInteraction000500564
      WBInteraction000500667
      WBInteraction000500677
      WBInteraction000500686
      WBInteraction000500758
      WBInteraction000500759
      WBInteraction000500804
      WBInteraction000500958
      WBInteraction000500959
      WBInteraction000500960
      WBInteraction000500961
      WBInteraction000500962
      WBInteraction000500963
      WBInteraction000500964
      WBInteraction000500965
      WBInteraction000500966
      WBInteraction000500967
      WBInteraction000500968
      WBInteraction000500969
      WBInteraction000500970
      WBInteraction000500971
      WBInteraction000500972
      WBInteraction000500973
      WBInteraction000500974
      WBInteraction000500975
      WBInteraction000500976
      WBInteraction000500977
      WBInteraction000501007
      WBInteraction000501014
      WBInteraction000501185
      WBInteraction000501186
      WBInteraction000501641
      WBInteraction000502157
      WBInteraction000502379
      WBInteraction000502559
      WBInteraction000502560
      WBInteraction000502561
      WBInteraction000502893
      WBInteraction000502894
      WBInteraction000503012
      WBInteraction000503013
      WBInteraction000503014
      WBInteraction000503506
      WBInteraction000503608
      WBInteraction000503611
      WBInteraction000503613
      WBInteraction000503616
      WBInteraction000503619
      WBInteraction000503620
      WBInteraction000503622
      WBInteraction000503725
      WBInteraction000504619
      WBInteraction000504621
      WBInteraction000517291
      WBInteraction000517292
      WBInteraction000518485
      WBInteraction000519170
      WBInteraction000519183
      WBInteraction000519184
      WBInteraction000519239
      WBInteraction000519836
      WBInteraction000520485
      WBInteraction000521756
      WBInteraction000521760
      WBInteraction000521761
      WBInteraction000522427
      WBInteraction000524186
      WBInteraction000524663
      WBInteraction000525165
      WBInteraction000525370
      WBInteraction000534853
      WBInteraction000534854
      WBInteraction000534855
      WBInteraction000534856
      WBInteraction000538726
      WBInteraction000539230
      WBInteraction000539361
      WBInteraction000539785
      WBInteraction000540338
      WBInteraction000540369
      WBInteraction000541011
      WBInteraction000541255
      WBInteraction000541258
      WBInteraction000541259
      WBInteraction000541396
      WBInteraction000541397
      WBInteraction000542770
      WBInteraction000542773
      WBInteraction000544777
      WBInteraction000544778
      WBInteraction000550867
      WBInteraction000552110
      WBInteraction000552938
      WBInteraction000555611
      WBInteraction000555947
      WBInteraction000555948
      WBInteraction000556007
      WBInteraction000557096
      WBInteraction000557540
      WBInteraction000557542
      WBInteraction000557634
      WBInteraction000557639
      WBInteraction000558157
      WBInteraction000558158
      WBInteraction000564889
      WBInteraction000568891
      WBInteraction000575412
      WBInteraction000578294
      WBInteraction000579003
      WBInteraction000579004
    Product_binds_matrix: WBPmat00005534
      WBPmat00005535
      WBPmat00005536
      WBPmat00005540
      WBPmat00005541
      WBPmat00005542
      WBPmat00005543
      WBPmat00005544
      WBPmat00005545
  Map_info: Map: I Position: 0.461719 Error: 0.000997
    Well_ordered
    Positive: Positive_clone: C32F10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 283
        308
        309
        4517
  Reference (253)
  Picture: WBPicture0000013091
  Method: Gene