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WormBase Tree Display for Gene: WBGene00001368

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Name Class

WBGene00001368EvidenceCGC_data_submission
SMapS_parentSequenceF35H8
IdentityVersion2
NameCGC_nameexc-7Person_evidenceWBPerson1052
Sequence_nameF35H8.5
Molecular_nameF35H8.5a
F35H8.5a.1
CE00983
F35H8.5b
Other_nameelr-1
cel-1Person_evidenceWBPerson1843
CELE_F35H8.5Accession_evidenceNDBBX284602
Public_nameexc-7
DB_infoDatabaseAceViewgene2J871
WormQTLgeneWBGene00001368
WormFluxgeneWBGene00001368
NDBlocus_tagCELE_F35H8.5
PanthergeneCAEEL|WormBase=WBGene00001368|UniProtKB=Q20084
familyPTHR24012
NCBIgene174506
RefSeqproteinNR_175828.1
NM_063656.6
TrEMBLUniProtAccQ20084
UniProt_GCRPUniProtAccQ20084
RNAcentralURSidURS000242F08E
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
209 Nov 2004 13:58:18WBPerson2970Name_changeOther_namecel-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classexc
Allele (88)
Legacy_information[Buechner M] exc for excretory canal defect. Canal is invariably short with multiple cysts of varying size clustered along length, especially at the tips. Visible only by Nomarski microscopy. Animal is somewhat pale.
[C.elegansII] rh252 : excretory canal defect. Canal is invariably short with multiple cysts of varying size clustered along length, especially at the tips. Visible only by Nomarski microscopy. Animal is somewhat pale. NA1. [NJ]
StrainWBStrain00002848
WBStrain00028852
WBStrain00035561
WBStrain00047414
RNASeq_FPKM (74)
GO_annotation (19)
Ortholog (55)
Paralog (15)
Structured_descriptionConcise_descriptionexc-7 encodes an ELAV, an mRNA-binding protein homologous to Drosophila ELAV and human HuC/D (OMIM:603458, 168360, autoimmune antigens associated with paraneoplastic neurologic disorders); EXC-7 is required for formation of the tailspike and the excretory cell canals; exc-7 mutations enhance defects produced by mutations in exc-3, predicted to encode a peptidase, and sma-1, which encodes beta H-spectrin, a key component of the apical cytokeleton of polarized epithelial cells such as the excretory cell; in vitro, EXC-7 can bind the sma-1 mRNA 3' UTR, and thus is predicted to regulate SMA-1 expression in vivo; EXC-7 is expressed transiently in the excretory cell nucleus during mid-embryogenesis and during larval stages is detected in the pharynx, nerve ring, and nerve cord nuclei.Paper_evidenceWBPaper00003721
WBPaper00005833
WBPaper00006029
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated02 Mar 2009 00:00:00
Automated_descriptionEnables single-stranded RNA binding activity. Involved in several processes, including epithelial cell development; regulation of alternative mRNA splicing, via spliceosome; and regulation of neuron differentiation. Located in nuclear speck. Expressed in several structures, including excretory cell; neurons; somatic nervous system; tail; and vulva. Is an ortholog of human ELAVL4 (ELAV like RNA binding protein 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF35H8.5a
Corresponding_transcriptF35H8.5b
F35H8.5a.1
Other_sequence (31)
Associated_feature (22)
Experimental_infoRNAi_resultWBRNAi00087534Inferred_automaticallyRNAi_primary
WBRNAi00080076Inferred_automaticallyRNAi_primary
WBRNAi00046434Inferred_automaticallyRNAi_primary
WBRNAi00080160Inferred_automaticallyRNAi_primary
WBRNAi00014387Inferred_automaticallyRNAi_primary
WBRNAi00031822Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_constructWBCnstr00003370
WBCnstr00010161
WBCnstr00010162
WBCnstr00010851
WBCnstr00010895
WBCnstr00036987
Construct_product (4)
Regulate_expr_clusterWBPaper00051540:exc-7(csb29);mbl-1(csb30)_downregulated
WBPaper00051540:exc-7(csb29);mbl-1(csb30)_upregulated
WBPaper00051540:exc-7(csb29)_downregulated
WBPaper00051540:exc-7(csb29)_upregulated
Microarray_results (24)
Expression_cluster (180)
InteractionWBInteraction000001818
WBInteraction000001819
WBInteraction000002080
WBInteraction000002081
WBInteraction000009621
WBInteraction000009622
WBInteraction000009904
WBInteraction000028566
WBInteraction000029297
WBInteraction000029611
WBInteraction000029612
WBInteraction000029996
WBInteraction000030484
WBInteraction000030485
WBInteraction000030486
WBInteraction000030487
WBInteraction000114182
WBInteraction000122652
WBInteraction000140900
WBInteraction000148654
WBInteraction000149162
WBInteraction000158032
WBInteraction000158033
WBInteraction000158034
WBInteraction000158035
WBInteraction000158557
WBInteraction000158647
WBInteraction000159403
WBInteraction000162220
WBInteraction000169205
WBInteraction000169206
WBInteraction000173156
WBInteraction000173157
WBInteraction000173158
WBInteraction000173397
WBInteraction000173835
WBInteraction000174240
WBInteraction000224388
WBInteraction000258024
WBInteraction000258978
WBInteraction000260653
WBInteraction000266175
WBInteraction000281482
WBInteraction000285808
WBInteraction000288944
WBInteraction000288989
WBInteraction000292947
WBInteraction000304249
WBInteraction000304376
WBInteraction000312749
WBInteraction000319063
WBInteraction000331381
WBInteraction000331880
WBInteraction000360539
WBInteraction000366064
WBInteraction000366207
WBInteraction000380338
WBInteraction000384002
WBInteraction000384129
WBInteraction000384416
WBInteraction000388232
WBInteraction000393321
WBInteraction000400810
WBInteraction000400819
WBInteraction000409539
WBInteraction000416369
WBInteraction000416604
WBInteraction000429717
WBInteraction000430238
WBInteraction000435842
WBInteraction000437940
WBInteraction000438697
WBInteraction000440613
WBInteraction000442764
WBInteraction000444014
WBInteraction000455870
WBInteraction000509993
WBInteraction000509994
WBInteraction000509995
WBInteraction000509996
WBInteraction000509997
WBInteraction000509998
WBInteraction000509999
WBInteraction000510000
WBInteraction000510001
WBInteraction000510002
WBInteraction000510003
WBInteraction000510004
WBInteraction000510005
WBInteraction000510006
WBInteraction000510007
WBInteraction000510008
WBInteraction000510009
WBInteraction000510011
WBInteraction000510012
WBInteraction000514448
WBInteraction000514449
WBInteraction000514453
WBInteraction000514455
WBInteraction000514458
WBInteraction000514459
WBInteraction000514461
WBInteraction000514462
WBInteraction000521544
WBInteraction000547199
WBInteraction000547996
WBInteraction000547997
WBInteraction000576805
Map_infoMapIIPosition1.60952Error0.004466
Well_ordered
PositivePositive_cloneE02H1
F35H8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point7027
Multi_point3292
4488
4753
Pos_neg_data8597
8598
8599
8600
8601
8602
8603
8604
8605
Reference (42)
MethodGene