WormBase Tree Display for Gene: WBGene00001224

WBGene00001224 SMap: S_parent: Sequence: ZK1248
  Identity: Version: 1
    Name: CGC_name: ehs-1 Person_evidence: WBPerson52
      Sequence_name: ZK1248.3
      Molecular_name (4)
      Other_name: CELE_ZK1248.3 Accession_evidence: NDB BX284602
      Public_name: ehs-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ehs
    Allele (41)
    Strain: WBStrain00003367
      WBStrain00029058
      WBStrain00051861
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (42)
    Paralog: WBGene00004373 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012696 Caenorhabditis elegans From_analysis: Panther
      WBGene00006405 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ehs-1 encodes an ortholog of mammalian Eps15; EHS-1 functions as an endocytic adaptor protein to regulate cargo sorting through the endolysosomal system; EHS-1 is also required, together with ITSN-1, for synaptic vesicle recycling and hence, regulation of neurotransmission; immunofluorescence staining of embryos indicates that EHS-1 localizes to the plasma membrane. Paper_evidence: WBPaper00004812
            WBPaper00042550
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 19 Sep 2013 00:00:00
      Automated_description: Involved in chemical synaptic transmission and synaptic vesicle endocytosis. Located in axon; plasma membrane; and synapse. Expressed in epithelial cell; intestine; muscle cell; and nervous system. Is an ortholog of human EPS15 (epidermal growth factor receptor pathway substrate 15) and EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1248.3a
    Corresponding_CDS_history: ZK1248.3b:wp185
      ZK1248.3b:wp261
    Corresponding_transcript: ZK1248.3b
      ZK1248.3a.1
    Other_sequence (20)
    Associated_feature: WBsf644227
      WBsf654841
      WBsf657628
      WBsf987967
      WBsf987968
      WBsf1012267
      WBsf221347
  Experimental_info: RNAi_result: WBRNAi00038185 Inferred_automatically: RNAi_primary
      WBRNAi00098749 Inferred_automatically: RNAi_primary
      WBRNAi00098750 Inferred_automatically: RNAi_primary
      WBRNAi00059191 Inferred_automatically: RNAi_primary
      WBRNAi00062548 Inferred_automatically: RNAi_primary
      WBRNAi00098748 Inferred_automatically: RNAi_primary
      WBRNAi00098503 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1017
      Expr1647
      Expr15238
      Expr15239
      Expr1024595
      Expr1030772
      Expr1162610
      Expr2011239
      Expr2029475
    Drives_construct: WBCnstr00003838
      WBCnstr00021034
      WBCnstr00037028
      WBCnstr00041790
    Construct_product: WBCnstr00037028
      WBCnstr00042134
      WBCnstr00042135
    Antibody: WBAntibody00000394
      WBAntibody00002466
    Microarray_results (31)
    Expression_cluster (109)
    Interaction: WBInteraction000001400
      WBInteraction000004835
      WBInteraction000009418
      WBInteraction000030460
      WBInteraction000035995
      WBInteraction000038941
      WBInteraction000046874
      WBInteraction000049015
      WBInteraction000049016
      WBInteraction000049017
      WBInteraction000049417
      WBInteraction000109882
      WBInteraction000110229
      WBInteraction000110274
      WBInteraction000110364
      WBInteraction000110411
      WBInteraction000112746
      WBInteraction000114905
      WBInteraction000115902
      WBInteraction000117895
      WBInteraction000133895
      WBInteraction000136826
      WBInteraction000141274
      WBInteraction000149074
      WBInteraction000150797
      WBInteraction000151654
      WBInteraction000151655
      WBInteraction000151656
      WBInteraction000151657
      WBInteraction000152436
      WBInteraction000162475
      WBInteraction000164318
      WBInteraction000166994
      WBInteraction000167042
      WBInteraction000167337
      WBInteraction000167650
      WBInteraction000167880
      WBInteraction000170155
      WBInteraction000172331
      WBInteraction000182210
      WBInteraction000183101
      WBInteraction000183801
      WBInteraction000184669
      WBInteraction000184679
      WBInteraction000185319
      WBInteraction000185431
      WBInteraction000186699
      WBInteraction000186810
      WBInteraction000190286
      WBInteraction000193935
      WBInteraction000195505
      WBInteraction000203512
      WBInteraction000206361
      WBInteraction000217398
      WBInteraction000221157
      WBInteraction000222968
      WBInteraction000226125
      WBInteraction000226209
      WBInteraction000232939
      WBInteraction000240599
      WBInteraction000243064
      WBInteraction000247979
      WBInteraction000247991
      WBInteraction000252547
      WBInteraction000252625
      WBInteraction000253571
      WBInteraction000262542
      WBInteraction000264434
      WBInteraction000266580
      WBInteraction000269972
      WBInteraction000273955
      WBInteraction000273966
      WBInteraction000281703
      WBInteraction000285576
      WBInteraction000306865
      WBInteraction000321884
      WBInteraction000329125
      WBInteraction000330200
      WBInteraction000331874
      WBInteraction000339792
      WBInteraction000339851
      WBInteraction000343801
      WBInteraction000349185
      WBInteraction000355138
      WBInteraction000355196
      WBInteraction000357921
      WBInteraction000358271
      WBInteraction000360669
      WBInteraction000361773
      WBInteraction000363584
      WBInteraction000363648
      WBInteraction000363649
      WBInteraction000364016
      WBInteraction000370297
      WBInteraction000387579
      WBInteraction000396266
      WBInteraction000407440
      WBInteraction000411485
      WBInteraction000416574
      WBInteraction000418034
      WBInteraction000423349
      WBInteraction000430089
      WBInteraction000431347
      WBInteraction000447931
      WBInteraction000448938
      WBInteraction000452726
      WBInteraction000453895
      WBInteraction000454644
      WBInteraction000457403
      WBInteraction000463441
      WBInteraction000463442
      WBInteraction000463443
      WBInteraction000463444
      WBInteraction000463445
      WBInteraction000469715
      WBInteraction000469716
      WBInteraction000473951
      WBInteraction000474871
      WBInteraction000503373
      WBInteraction000503503
      WBInteraction000521840
      WBInteraction000522806
      WBInteraction000523639
      WBInteraction000523672
      WBInteraction000523695
      WBInteraction000523758
      WBInteraction000523767
      WBInteraction000523770
      WBInteraction000523771
      WBInteraction000523776
      WBInteraction000523778
      WBInteraction000523779
      WBInteraction000523780
      WBInteraction000523781
      WBInteraction000523782
      WBInteraction000523783
      WBInteraction000523784
      WBInteraction000523785
      WBInteraction000523791
      WBInteraction000523801
      WBInteraction000538785
      WBInteraction000541001
      WBInteraction000541316
      WBInteraction000541317
      WBInteraction000541318
      WBInteraction000541319
      WBInteraction000541320
      WBInteraction000541321
      WBInteraction000541322
      WBInteraction000541323
      WBInteraction000541324
      WBInteraction000541325
      WBInteraction000541326
      WBInteraction000541327
      WBInteraction000541328
      WBInteraction000541329
      WBInteraction000541330
      WBInteraction000541331
      WBInteraction000541370
      WBInteraction000541371
      WBInteraction000542046
      WBInteraction000544019
      WBInteraction000545882
      WBInteraction000545987
      WBInteraction000546169
      WBInteraction000546177
      WBInteraction000546273
      WBInteraction000546413
      WBInteraction000546532
      WBInteraction000546598
      WBInteraction000546735
      WBInteraction000546810
      WBInteraction000546835
      WBInteraction000547169
      WBInteraction000547510
      WBInteraction000548477
      WBInteraction000548769
      WBInteraction000550854
      WBInteraction000556516
      WBInteraction000564554
      WBInteraction000564569
      WBInteraction000564580
      WBInteraction000574311
      WBInteraction000584456
  Map_info: Map: II Position: -0.914871 Error: 0.00257
    Positive: Positive_clone: ZK1248 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4278
        5321
        5611
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene