WormBase Tree Display for Gene: WBGene00000796

WBGene00000796 Evidence: Paper_evidence: WBPaper00005857
  SMap: S_parent: Sequence: C14A4
  Identity: Version: 2
    Name: CGC_name: crn-3 Person_evidence: WBPerson1606
      Sequence_name: C14A4.4
      Molecular_name: C14A4.4a
        C14A4.4a.1
        CE02145
        C14A4.4b
        CE51406
        C14A4.4b.1
      Other_name: exos-10 Person_evidence: WBPerson699
            WBPerson6229
        CELE_C14A4.4 Accession_evidence: NDB BX284602
      Public_name: crn-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Jun 2007 15:54:19 WBPerson2970 Name_change: Other_name: exos-10
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: crn
    Allele (78)
    Strain: WBStrain00036816
      WBStrain00007421
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP2496
    Ortholog (39)
    Paralog: WBGene00013256 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015680 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. Paper_evidence: WBPaper00004424
            WBPaper00005857
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be located in nucleolus. Predicted to be part of nuclear exosome (RNase complex). Is an ortholog of human EXOSC10 (exosome component 10). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C14A4.4a
      C14A4.4b
    Corresponding_CDS_history: C14A4.4b:wp252
    Corresponding_transcript: C14A4.4a.1
      C14A4.4b.1
    Other_sequence (17)
    Associated_feature: WBsf658150
      WBsf222034
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr16396
      Expr1026985
      Expr1030495
      Expr1144539
      Expr2010538
      Expr2028778
    Drives_construct (2)
    Construct_product: WBCnstr00037270
      WBCnstr00042997
    Microarray_results (29)
    Expression_cluster (121)
    SAGE_tag (15)
    Interaction: WBInteraction000002092
      WBInteraction000028771
      WBInteraction000048557
      WBInteraction000050544
      WBInteraction000050545
      WBInteraction000050546
      WBInteraction000050547
      WBInteraction000050548
      WBInteraction000105075
      WBInteraction000105080
      WBInteraction000105109
      WBInteraction000105679
      WBInteraction000106588
      WBInteraction000107021
      WBInteraction000107045
      WBInteraction000109593
      WBInteraction000113669
      WBInteraction000114490
      WBInteraction000114491
      WBInteraction000114492
      WBInteraction000114494
      WBInteraction000114866
      WBInteraction000135923
      WBInteraction000136151
      WBInteraction000137412
      WBInteraction000138532
      WBInteraction000138838
      WBInteraction000139129
      WBInteraction000140529
      WBInteraction000140548
      WBInteraction000140803
      WBInteraction000141485
      WBInteraction000142103
      WBInteraction000143763
      WBInteraction000146488
      WBInteraction000147587
      WBInteraction000147876
      WBInteraction000148220
      WBInteraction000148574
      WBInteraction000149838
      WBInteraction000150010
      WBInteraction000150111
      WBInteraction000151799
      WBInteraction000156533
      WBInteraction000156772
      WBInteraction000157818
      WBInteraction000157922
      WBInteraction000163329
      WBInteraction000163781
      WBInteraction000164859
      WBInteraction000165575
      WBInteraction000170925
      WBInteraction000171434
      WBInteraction000171497
      WBInteraction000172404
      WBInteraction000174838
      WBInteraction000175773
      WBInteraction000176356
      WBInteraction000176393
      WBInteraction000176399
      WBInteraction000176706
      WBInteraction000177486
      WBInteraction000178091
      WBInteraction000178707
      WBInteraction000180518
      WBInteraction000182108
      WBInteraction000182937
      WBInteraction000186307
      WBInteraction000186727
      WBInteraction000187831
      WBInteraction000188453
      WBInteraction000188537
      WBInteraction000194786
      WBInteraction000196405
      WBInteraction000197473
      WBInteraction000198766
      WBInteraction000199075
      WBInteraction000200063
      WBInteraction000200820
      WBInteraction000203980
      WBInteraction000204159
      WBInteraction000205843
      WBInteraction000208748
      WBInteraction000211938
      WBInteraction000212380
      WBInteraction000213406
      WBInteraction000215515
      WBInteraction000216287
      WBInteraction000216903
      WBInteraction000220835
      WBInteraction000222715
      WBInteraction000226148
      WBInteraction000226223
      WBInteraction000232008
      WBInteraction000233066
      WBInteraction000233067
      WBInteraction000233068
      WBInteraction000233069
      WBInteraction000233070
      WBInteraction000233071
      WBInteraction000233072
      WBInteraction000233073
      WBInteraction000233074
      WBInteraction000233075
      WBInteraction000233076
      WBInteraction000233077
      WBInteraction000233155
      WBInteraction000235619
      WBInteraction000237115
      WBInteraction000240162
      WBInteraction000240391
      WBInteraction000240392
      WBInteraction000240393
      WBInteraction000240394
      WBInteraction000240395
      WBInteraction000243201
      WBInteraction000247260
      WBInteraction000247333
      WBInteraction000247334
      WBInteraction000248116
      WBInteraction000249562
      WBInteraction000251606
      WBInteraction000259553
      WBInteraction000261196
      WBInteraction000265726
      WBInteraction000269946
      WBInteraction000270325
      WBInteraction000282222
      WBInteraction000283043
      WBInteraction000284348
      WBInteraction000285579
      WBInteraction000289347
      WBInteraction000298539
      WBInteraction000311600
      WBInteraction000312949
      WBInteraction000316432
      WBInteraction000316433
      WBInteraction000319855
      WBInteraction000323450
      WBInteraction000330277
      WBInteraction000331071
      WBInteraction000336091
      WBInteraction000337559
      WBInteraction000337784
      WBInteraction000343482
      WBInteraction000345728
      WBInteraction000348950
      WBInteraction000353395
      WBInteraction000355060
      WBInteraction000356982
      WBInteraction000357289
      WBInteraction000357433
      WBInteraction000358264
      WBInteraction000361094
      WBInteraction000364899
      WBInteraction000365250
      WBInteraction000365325
      WBInteraction000368492
      WBInteraction000370572
      WBInteraction000375596
      WBInteraction000376934
      WBInteraction000377349
      WBInteraction000386338
      WBInteraction000387706
      WBInteraction000388481
      WBInteraction000393614
      WBInteraction000396000
      WBInteraction000398288
      WBInteraction000400493
      WBInteraction000401649
      WBInteraction000402861
      WBInteraction000406530
      WBInteraction000407707
      WBInteraction000411673
      WBInteraction000411748
      WBInteraction000411781
      WBInteraction000416172
      WBInteraction000419318
      WBInteraction000425491
      WBInteraction000430130
      WBInteraction000432994
      WBInteraction000438190
      WBInteraction000439154
      WBInteraction000442582
      WBInteraction000446214
      WBInteraction000447764
      WBInteraction000449023
      WBInteraction000450685
      WBInteraction000455536
      WBInteraction000458929
      WBInteraction000459049
      WBInteraction000461714
      WBInteraction000462056
      WBInteraction000464046
      WBInteraction000464052
      WBInteraction000464135
      WBInteraction000465445
      WBInteraction000466229
      WBInteraction000466363
      WBInteraction000466974
      WBInteraction000467950
      WBInteraction000468000
      WBInteraction000469782
      WBInteraction000471728
      WBInteraction000472262
      WBInteraction000472993
      WBInteraction000473143
      WBInteraction000473840
      WBInteraction000474608
      WBInteraction000474906
      WBInteraction000475395
      WBInteraction000541429
      WBInteraction000541434
      WBInteraction000541439
      WBInteraction000541442
      WBInteraction000541443
      WBInteraction000541446
      WBInteraction000541452
      WBInteraction000541457
      WBInteraction000541460
      WBInteraction000570415
      WBInteraction000574996
      WBInteraction000575864
      WBInteraction000582916
    WBProcess: WBbiopr:00000014
      WBbiopr:00000103
  Map_info: Map: II Position: 3.11949 Error: 0.000279
    Positive: Positive_clone: C14A4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005857
    WBPaper00006283
    WBPaper00019408
    WBPaper00027291
    WBPaper00038491
    WBPaper00048226
    WBPaper00055090
    WBPaper00057242
    WBPaper00065012
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene