WormBase Tree Display for Gene: WBGene00000371

WBGene00000371 Evidence: Paper_evidence: WBPaper00005707
  SMap: S_parent: Sequence: F26E4
  Identity: Version: 2
    Name: CGC_name: cox-5B Person_evidence: WBPerson117
            WBPerson7169
      Sequence_name: F26E4.9
      Molecular_name: F26E4.9
        F26E4.9.1
        CE09693
        F26E4.9.2
      Other_name: lpd-4 CGC_data_submission
        cco-1 Person_evidence: WBPerson1157
        CELE_F26E4.9 Accession_evidence: NDB BX284601
      Public_name: cox-5B
    DB_info: Database (10)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Sep 2017 13:25:30 WBPerson2970 Name_change: CGC_name: cox-5B
                Other_name: cco-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cox
    Allele (21)
    Component_of_genotype: WBGenotype00000141
    RNASeq_FPKM (74)
    GO_annotation: 00049238
      00049239
      00049240
      00049241
      00049242
      00049243
      00107246
      00107247
      00107248
    Contained_in_operon: CEOP1930
    Ortholog (38)
    Structured_description: Concise_description: cox-5b encodes the ortholog of the nuclear-encoded cytochrome c oxidase-1 subunit Vb/COX4, a component of the electron transport chain in mitochondria; knock-down of cox-5b via RNA interference in specific tissues like body wall muscle decreases life span, whereas knock-down in the nervous system and intestine increases life-span; the effects of cox-5b on life span indicate that the electron transport chain functions in a tissue-specific manner to affect the aging process, and studies show that this effect is dependent on the mitochondrial unfolded protein response. Paper_evidence: WBPaper00037991
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 May 2011 00:00:00
      Automated_description: Predicted to enable metal ion binding activity. Involved in determination of adult lifespan; lipid storage; and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial envelope. Predicted to be part of mitochondrial respiratory chain complex IV. Is an ortholog of human COX5B (cytochrome c oxidase subunit 5B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:450
  Modifies_disease_in_annotation: WBDOannot00001305
  Molecular_info: Corresponding_CDS: F26E4.9
    Corresponding_transcript: F26E4.9.1
      F26E4.9.2
    Other_sequence (85)
    Associated_feature: WBsf643631
      WBsf981084
      WBsf984809
      WBsf984810
      WBsf218348
      WBsf218349
      WBsf218350
      WBsf218351
      WBsf218352
  Experimental_info: RNAi_result (135)
    Expr_pattern: Expr1011393
      Expr1030199
      Expr1149560
      Expr2009764
      Expr2028004
    Drives_construct: WBCnstr00037591
    Construct_product: WBCnstr00020784
      WBCnstr00020785
      WBCnstr00037591
    Regulate_expr_cluster (15)
    Microarray_results (26)
    Expression_cluster (112)
    Interaction: WBInteraction000003645
      WBInteraction000006743
      WBInteraction000006907
      WBInteraction000007132
      WBInteraction000007161
      WBInteraction000007234
      WBInteraction000029268
      WBInteraction000042309
      WBInteraction000044422
      WBInteraction000049468
      WBInteraction000111431
      WBInteraction000111432
      WBInteraction000111433
      WBInteraction000111434
      WBInteraction000149957
      WBInteraction000153371
      WBInteraction000153423
      WBInteraction000153459
      WBInteraction000153519
      WBInteraction000153520
      WBInteraction000153521
      WBInteraction000153522
      WBInteraction000153523
      WBInteraction000153524
      WBInteraction000153525
      WBInteraction000153526
      WBInteraction000153527
      WBInteraction000153528
      WBInteraction000153529
      WBInteraction000153530
      WBInteraction000153531
      WBInteraction000153532
      WBInteraction000153598
      WBInteraction000165500
      WBInteraction000184236
      WBInteraction000186601
      WBInteraction000221060
      WBInteraction000234334
      WBInteraction000244630
      WBInteraction000249090
      WBInteraction000254876
      WBInteraction000261803
      WBInteraction000288743
      WBInteraction000298430
      WBInteraction000318533
      WBInteraction000319119
      WBInteraction000337804
      WBInteraction000356167
      WBInteraction000376177
      WBInteraction000383997
      WBInteraction000392640
      WBInteraction000408315
      WBInteraction000409346
      WBInteraction000409822
      WBInteraction000409856
      WBInteraction000413598
      WBInteraction000437648
      WBInteraction000501243
      WBInteraction000502920
      WBInteraction000504798
      WBInteraction000520622
      WBInteraction000520682
      WBInteraction000520719
      WBInteraction000525068
      WBInteraction000535418
      WBInteraction000536345
      WBInteraction000536350
      WBInteraction000536355
      WBInteraction000536813
      WBInteraction000537143
      WBInteraction000537283
      WBInteraction000537286
      WBInteraction000537428
      WBInteraction000537458
      WBInteraction000537461
      WBInteraction000537490
      WBInteraction000537491
      WBInteraction000537494
      WBInteraction000537497
      WBInteraction000537498
      WBInteraction000537501
      WBInteraction000537550
      WBInteraction000537555
      WBInteraction000537561
      WBInteraction000537577
      WBInteraction000537579
      WBInteraction000537580
      WBInteraction000537582
      WBInteraction000537586
      WBInteraction000537587
      WBInteraction000537588
      WBInteraction000537590
      WBInteraction000537592
      WBInteraction000537594
      WBInteraction000537595
      WBInteraction000537596
      WBInteraction000537598
      WBInteraction000537601
      WBInteraction000537603
      WBInteraction000537604
      WBInteraction000537605
      WBInteraction000537607
      WBInteraction000537608
      WBInteraction000537611
      WBInteraction000537612
      WBInteraction000537613
      WBInteraction000537614
      WBInteraction000537618
      WBInteraction000537619
      WBInteraction000537620
      WBInteraction000537621
      WBInteraction000553916
      WBInteraction000559227
      WBInteraction000560335
      WBInteraction000561984
      WBInteraction000566399
      WBInteraction000566678
      WBInteraction000570942
      WBInteraction000572452
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: I Position: 3.90842 Error: 0.000958
    Positive: Positive_clone: F26E4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (41)
  Remark: This gene was formerly known as lpd-4 and was renamed following advice from the CGC. [krb 030512]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene