WormBase Tree Display for Gene: WBGene00000195
expand all nodes | collapse all nodes | view schema
WBGene00000195 | SMap | S_parent | Sequence | F53H8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | arr | ||||||
Allele (60) | |||||||
Strain | WBStrain00031400 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00047486 | ||||||
00047487 | |||||||
00047488 | |||||||
00047489 | |||||||
00047490 | |||||||
00047491 | |||||||
00047492 | |||||||
00047493 | |||||||
00106977 | |||||||
Ortholog (47) | |||||||
Structured_description | Concise_description | arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis. | Paper_evidence | WBPaper00005520 | |||
WBPaper00013467 | |||||||
WBPaper00025173 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 25 Jun 2007 00:00:00 | ||||||
Automated_description | Predicted to enable G protein-coupled receptor binding activity. Involved in positive regulation of growth rate. Predicted to be located in cytoplasm. Expressed in HSN; amphid neurons; somatic nervous system; and tail. Human ortholog(s) of this gene implicated in eye disease (multiple); major depressive disorder; and portal hypertension. Is an ortholog of human ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (12) | ||||||
Molecular_info | Corresponding_CDS | F53H8.2 | |||||
Corresponding_transcript | F53H8.2.1 | ||||||
Other_sequence (23) | |||||||
Associated_feature | WBsf647807 | ||||||
WBsf662449 | |||||||
WBsf662450 | |||||||
WBsf1003900 | |||||||
WBsf1003901 | |||||||
WBsf1003902 | |||||||
WBsf1003903 | |||||||
WBsf235298 | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Expr4299 | ||||||
Expr6162 | |||||||
Expr6163 | |||||||
Expr8610 | |||||||
Expr8611 | |||||||
Expr1015865 | |||||||
Expr1030114 | |||||||
Expr1152011 | |||||||
Expr2009408 | |||||||
Expr2027644 | |||||||
Drives_construct | WBCnstr00002995 | ||||||
WBCnstr00004493 | |||||||
WBCnstr00011896 | |||||||
WBCnstr00013399 | |||||||
WBCnstr00037671 | |||||||
WBCnstr00038325 | |||||||
Construct_product | WBCnstr00013399 | ||||||
WBCnstr00037671 | |||||||
WBCnstr00038320 | |||||||
WBCnstr00038321 | |||||||
WBCnstr00038322 | |||||||
WBCnstr00038323 | |||||||
WBCnstr00038324 | |||||||
WBCnstr00038325 | |||||||
Antibody | WBAntibody00001658 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (120) | |||||||
Interaction | WBInteraction000037595 | ||||||
WBInteraction000047672 | |||||||
WBInteraction000116183 | |||||||
WBInteraction000142057 | |||||||
WBInteraction000144306 | |||||||
WBInteraction000147308 | |||||||
WBInteraction000148151 | |||||||
WBInteraction000150584 | |||||||
WBInteraction000150585 | |||||||
WBInteraction000150964 | |||||||
WBInteraction000150968 | |||||||
WBInteraction000152376 | |||||||
WBInteraction000152471 | |||||||
WBInteraction000157877 | |||||||
WBInteraction000159913 | |||||||
WBInteraction000159916 | |||||||
WBInteraction000160918 | |||||||
WBInteraction000162238 | |||||||
WBInteraction000162239 | |||||||
WBInteraction000162893 | |||||||
WBInteraction000164213 | |||||||
WBInteraction000164229 | |||||||
WBInteraction000166943 | |||||||
WBInteraction000167000 | |||||||
WBInteraction000170003 | |||||||
WBInteraction000172891 | |||||||
WBInteraction000173419 | |||||||
WBInteraction000173536 | |||||||
WBInteraction000240460 | |||||||
WBInteraction000264899 | |||||||
WBInteraction000288354 | |||||||
WBInteraction000304074 | |||||||
WBInteraction000327931 | |||||||
WBInteraction000331790 | |||||||
WBInteraction000336534 | |||||||
WBInteraction000339635 | |||||||
WBInteraction000339636 | |||||||
WBInteraction000339858 | |||||||
WBInteraction000397860 | |||||||
WBInteraction000431390 | |||||||
WBInteraction000448844 | |||||||
WBInteraction000519007 | |||||||
WBInteraction000519008 | |||||||
WBInteraction000519009 | |||||||
WBInteraction000519010 | |||||||
WBInteraction000519011 | |||||||
WBInteraction000536784 | |||||||
WBInteraction000536785 | |||||||
WBInteraction000536786 | |||||||
WBInteraction000536787 | |||||||
WBInteraction000541237 | |||||||
WBInteraction000541250 | |||||||
Anatomy_function (11) | |||||||
Map_info | Map | X | Position | -18.9097 | Error | 0.005023 | |
Positive | Positive_clone | F53H8 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4163 | |||||
Pseudo_map_position | |||||||
Reference (25) | |||||||
Remark | Sequence connection from [Palmitessa A, Benovic J.], 02/06/12 krb. | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |