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WormBase Tree Display for Gene: WBGene00000121

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Name Class

WBGene00000121SMapS_parentSequenceF23B2
IdentityVersion2
NameCGC_namealy-2Person_evidenceWBPerson297
WBPerson4981
Sequence_nameF23B2.6
Molecular_name (3)
Other_nameref-2Paper_evidenceWBPaper00013477
CELE_F23B2.6Accession_evidenceNDBBX284604
Public_namealy-2
DB_infoDatabaseAceViewgene4J913
WormQTLgeneWBGene00000121
WormFluxgeneWBGene00000121
NDBlocus_tagCELE_F23B2.6
PanthergeneCAEEL|WormBase=WBGene00000121|UniProtKB=O62183
familyPTHR19965
NCBIgene177738
RefSeqproteinNM_069193.7
TREEFAMTREEFAM_IDTF313312
TrEMBLUniProtAccO62183
UniProt_GCRPUniProtAccO62183
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
227 Apr 2005 13:39:18WBPerson2970Name_changeOther_nameref-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaly
Allele (28)
StrainWBStrain00031866
RNASeq_FPKM (74)
GO_annotation00037249
00037250
00037251
00037252
00106835
Ortholog (51)
ParalogWBGene00000120Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00000122Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00015329Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionaly-2 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-2 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-1 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-1, ALY-2 and its paralog ALY-1 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; aly-2(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-2 is thought to promote recruitment of mRNA export factor to mRNAs; other than these sex-determination phenotypes, ALY-2 has no grossly obvious function in four-way RNAi assays of ALY-1/-3 and W04D2.6.Paper_evidenceWBPaper00013477
WBPaper00030790
Curator_confirmedWBPerson567
Date_last_updated09 Dec 2007 00:00:00
Automated_descriptionPredicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Is an ortholog of human ALYREF (Aly/REF export factor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF23B2.6
Corresponding_transcriptF23B2.6.1
Other_sequenceCGC01173_1
CJC05522_1
CR01957
CBC10390_1
CRC02984_1
CBC00520_1
CRC09193_1
Associated_featureWBsf646218
WBsf228792
Gene_product_binds (11001)
Transcription_factorWBTranscriptionFactor000754
Experimental_infoRNAi_result (18)
Expr_patternExpr13879
Expr1028128
Expr1030067
Expr1149316
Expr1200068
Expr2009317
Expr2027553
Drives_constructWBCnstr00037717
Construct_productWBCnstr00017321
WBCnstr00037717
WBCnstr00040227
Microarray_results (18)
Expression_cluster (169)
InteractionWBInteraction000143735
WBInteraction000144637
WBInteraction000151355
WBInteraction000165332
WBInteraction000171587
WBInteraction000172261
WBInteraction000191295
WBInteraction000208238
WBInteraction000213604
WBInteraction000213839
WBInteraction000219296
WBInteraction000226475
WBInteraction000228795
WBInteraction000237262
WBInteraction000238041
WBInteraction000245243
WBInteraction000252575
WBInteraction000254142
WBInteraction000255334
WBInteraction000260055
WBInteraction000263105
WBInteraction000265199
WBInteraction000265265
WBInteraction000267592
WBInteraction000270911
WBInteraction000271084
WBInteraction000271228
WBInteraction000274134
WBInteraction000275103
WBInteraction000279152
WBInteraction000284635
WBInteraction000285155
WBInteraction000290395
WBInteraction000291789
WBInteraction000292365
WBInteraction000293839
WBInteraction000295121
WBInteraction000297448
WBInteraction000298460
WBInteraction000299655
WBInteraction000299984
WBInteraction000300502
WBInteraction000308675
WBInteraction000316534
WBInteraction000329176
WBInteraction000335928
WBInteraction000337619
WBInteraction000340394
WBInteraction000340586
WBInteraction000340700
WBInteraction000341018
WBInteraction000341739
WBInteraction000342877
WBInteraction000342956
WBInteraction000346994
WBInteraction000347186
WBInteraction000350208
WBInteraction000352044
WBInteraction000352703
WBInteraction000353351
WBInteraction000353645
WBInteraction000355063
WBInteraction000355560
WBInteraction000355610
WBInteraction000356056
WBInteraction000357724
WBInteraction000362014
WBInteraction000363921
WBInteraction000364144
WBInteraction000365635
WBInteraction000365729
WBInteraction000369902
WBInteraction000372020
WBInteraction000374989
WBInteraction000375887
WBInteraction000376736
WBInteraction000377887
WBInteraction000379118
WBInteraction000383601
WBInteraction000386913
WBInteraction000391840
WBInteraction000393887
WBInteraction000394719
WBInteraction000396957
WBInteraction000399928
WBInteraction000401373
WBInteraction000402558
WBInteraction000405373
WBInteraction000407754
WBInteraction000409761
WBInteraction000410270
WBInteraction000413865
WBInteraction000414721
WBInteraction000415593
WBInteraction000434257
WBInteraction000436415
WBInteraction000436601
WBInteraction000441483
WBInteraction000442762
WBInteraction000454280
WBInteraction000460865
WBInteraction000463095
WBInteraction000465408
WBInteraction000467366
WBInteraction000468156
WBInteraction000468654
WBInteraction000469292
WBInteraction000474194
WBInteraction000500386
WBInteraction000552686
WBInteraction000559217
WBInteraction000563642
WBInteraction000565793
WBInteraction000570082
WBInteraction000582138
WBInteraction000582885
Map_infoMapIVPosition4.08336Error0.004606
PositivePositive_cloneF23B2Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4892
4754
Pseudo_map_position
Reference (20)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
Published as ref-2. The CGC approved ref-2 is a different sequence with ID WBGene00004335Paper_evidenceWBPaper00013477
MethodGene