WormBase Tree Display for Gene: WBGene00001017

WBGene00001017 SMap: S_parent: Sequence: ZK593
  Identity: Version: 1
    Name: CGC_name: dnc-1 Person_evidence: WBPerson689
      Sequence_name: ZK593.5
      Molecular_name (15)
      Other_name: CELE_ZK593.5 Accession_evidence: NDB BX284604
      Public_name: dnc-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dnc
    Allele (77)
    Possibly_affected_by: WBVar02153206
    Strain: WBStrain00007336
      WBStrain00007349
      WBStrain00024321
    RNASeq_FPKM (74)
    GO_annotation (35)
    Ortholog (40)
    Paralog: WBGene00009987 Caenorhabditis elegans From_analysis: Panther
      WBGene00010796 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: dnc-1 encodes the C. elegans ortholog of the dynactin complex subunit p150/GLUED/DCTN1; dnc-1 is required for pronuclear migration and centrosome separation in one-cell embryos and for the correct alignment of mitotic spindles in early embryos; DNC-1 shares embryonic functions with DNC-2, DHC-1, LIS-1 and NUD-1; DNC-1 is part of the multisubunit dynactin complex in vivo, and physically interacts specifically with the DNC-2 and DNC-3 dynactin subunits; DNC-1 is located at cortical microtubule attachment sites. Paper_evidence: WBPaper00003225
            WBPaper00003704
            WBPaper00004895
            WBPaper00018056
            WBPaper00037699
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 08 Aug 2012 00:00:00
      Automated_description: Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is an ortholog of human DCTN1 (dynactin subunit 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060486 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2711)
      DOID:0111202 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2711)
      DOID:0060193 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2711)
  Molecular_info: Corresponding_CDS: ZK593.5a
      ZK593.5b
      ZK593.5c
      ZK593.5d
      ZK593.5e
    Corresponding_CDS_history: ZK593.5:wp78
    Corresponding_transcript: ZK593.5a.1
      ZK593.5b.1
      ZK593.5c.1
      ZK593.5d.1
      ZK593.5e.1
    Other_sequence (13)
    Associated_feature (12)
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr1254
      Expr9603
      Expr15122
      Expr1016044
      Expr1030631
      Expr1162944
      Expr2010978
      Expr2029216
    Drives_construct: WBCnstr00037141
    Construct_product: WBCnstr00001381
      WBCnstr00007598
      WBCnstr00037141
    Antibody: WBAntibody00000192
      WBAntibody00001320
      WBAntibody00001493
      WBAntibody00002751
    Microarray_results (25)
    Expression_cluster (109)
    Interaction: WBInteraction000028422
      WBInteraction000029239
      WBInteraction000029343
      WBInteraction000032586
      WBInteraction000032789
      WBInteraction000032926
      WBInteraction000033122
      WBInteraction000033285
      WBInteraction000033923
      WBInteraction000034969
      WBInteraction000034983
      WBInteraction000035770
      WBInteraction000036363
      WBInteraction000036493
      WBInteraction000037229
      WBInteraction000037581
      WBInteraction000037831
      WBInteraction000038373
      WBInteraction000038672
      WBInteraction000038917
      WBInteraction000039941
      WBInteraction000040011
      WBInteraction000040240
      WBInteraction000040481
      WBInteraction000041296
      WBInteraction000041716
      WBInteraction000042520
      WBInteraction000042593
      WBInteraction000043484
      WBInteraction000045945
      WBInteraction000045946
      WBInteraction000046058
      WBInteraction000046899
      WBInteraction000047117
      WBInteraction000047177
      WBInteraction000049075
      WBInteraction000049564
      WBInteraction000126512
      WBInteraction000135420
      WBInteraction000137967
      WBInteraction000140873
      WBInteraction000142663
      WBInteraction000145469
      WBInteraction000157356
      WBInteraction000157822
      WBInteraction000157835
      WBInteraction000157848
      WBInteraction000157861
      WBInteraction000157892
      WBInteraction000159754
      WBInteraction000162563
      WBInteraction000162566
      WBInteraction000162645
      WBInteraction000162980
      WBInteraction000165102
      WBInteraction000165256
      WBInteraction000169486
      WBInteraction000169598
      WBInteraction000169748
      WBInteraction000169933
      WBInteraction000170023
      WBInteraction000174056
      WBInteraction000174077
      WBInteraction000174333
      WBInteraction000174334
      WBInteraction000181192
      WBInteraction000182259
      WBInteraction000182885
      WBInteraction000186353
      WBInteraction000189945
      WBInteraction000193429
      WBInteraction000196722
      WBInteraction000207801
      WBInteraction000209627
      WBInteraction000213223
      WBInteraction000214250
      WBInteraction000216012
      WBInteraction000218778
      WBInteraction000219123
      WBInteraction000219913
      WBInteraction000220649
      WBInteraction000230762
      WBInteraction000232739
      WBInteraction000236103
      WBInteraction000236261
      WBInteraction000240517
      WBInteraction000240518
      WBInteraction000248958
      WBInteraction000251621
      WBInteraction000252413
      WBInteraction000254083
      WBInteraction000263738
      WBInteraction000264849
      WBInteraction000267085
      WBInteraction000270436
      WBInteraction000278923
      WBInteraction000283170
      WBInteraction000283532
      WBInteraction000296134
      WBInteraction000298526
      WBInteraction000298638
      WBInteraction000302408
      WBInteraction000304330
      WBInteraction000309303
      WBInteraction000313301
      WBInteraction000314256
      WBInteraction000319962
      WBInteraction000325349
      WBInteraction000329070
      WBInteraction000330704
      WBInteraction000334683
      WBInteraction000342595
      WBInteraction000342933
      WBInteraction000344081
      WBInteraction000347842
      WBInteraction000348090
      WBInteraction000351456
      WBInteraction000353992
      WBInteraction000355280
      WBInteraction000355705
      WBInteraction000356621
      WBInteraction000358264
      WBInteraction000362035
      WBInteraction000371090
      WBInteraction000376629
      WBInteraction000381155
      WBInteraction000382300
      WBInteraction000386495
      WBInteraction000389384
      WBInteraction000390412
      WBInteraction000400686
      WBInteraction000403749
      WBInteraction000405346
      WBInteraction000405463
      WBInteraction000405660
      WBInteraction000426639
      WBInteraction000427242
      WBInteraction000435530
      WBInteraction000436815
      WBInteraction000438448
      WBInteraction000440330
      WBInteraction000441927
      WBInteraction000442332
      WBInteraction000448026
      WBInteraction000448287
      WBInteraction000458061
      WBInteraction000459258
      WBInteraction000461276
      WBInteraction000501150
      WBInteraction000501151
      WBInteraction000501990
      WBInteraction000503375
      WBInteraction000503437
      WBInteraction000503438
      WBInteraction000504660
      WBInteraction000517638
      WBInteraction000517666
      WBInteraction000517727
      WBInteraction000522337
      WBInteraction000522347
      WBInteraction000522349
      WBInteraction000522351
      WBInteraction000522352
      WBInteraction000522353
      WBInteraction000522355
      WBInteraction000522357
      WBInteraction000522359
      WBInteraction000523016
      WBInteraction000523163
      WBInteraction000523330
      WBInteraction000540426
      WBInteraction000543899
      WBInteraction000543928
      WBInteraction000559723
      WBInteraction000560238
      WBInteraction000561577
      WBInteraction000561578
      WBInteraction000571371
      WBInteraction000574951
      WBInteraction000577535
      WBInteraction000578305
      WBInteraction000582932
      WBInteraction000586609
  Map_info: Map: IV Position: 4.75022 Error: 0.003469
    Positive: Positive_clone: ZK593 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4263
        5510
    Pseudo_map_position
  Reference: WBPaper00003225
    WBPaper00003704
    WBPaper00004115
    WBPaper00004211
    WBPaper00004509
    WBPaper00004895
    WBPaper00005830
    WBPaper00006494
    WBPaper00010571
    WBPaper00012731
    WBPaper00017022
    WBPaper00018046
    WBPaper00018056
    WBPaper00018959
    WBPaper00019315
    WBPaper00024200
    WBPaper00024358
    WBPaper00025115
    WBPaper00026060
    WBPaper00026308
    WBPaper00028423
    WBPaper00028448
    WBPaper00028886
    WBPaper00029395
    WBPaper00031120
    WBPaper00031224
    WBPaper00031420
    WBPaper00031546
    WBPaper00034745
    WBPaper00035228
    WBPaper00035468
    WBPaper00035598
    WBPaper00037699
    WBPaper00037731
    WBPaper00037976
    WBPaper00037977
    WBPaper00038491
    WBPaper00039750
    WBPaper00042019
    WBPaper00043337
    WBPaper00043908
    WBPaper00044534
    WBPaper00045213
    WBPaper00047002
    WBPaper00048209
    WBPaper00049531
    WBPaper00052141
    WBPaper00052206
    WBPaper00052847
    WBPaper00055090
    WBPaper00056116
    WBPaper00057024
    WBPaper00057896
    WBPaper00057909
    WBPaper00058751
    WBPaper00060885
    WBPaper00060994
    WBPaper00061547
    WBPaper00062341
    WBPaper00063158
    WBPaper00064298
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene