WormBase Tree Display for Gene: WBGene00004385

WBGene00004385 Evidence: Person_evidence: WBPerson71
      WBPerson395
  SMap: S_parent: Sequence: K08D10
  Identity: Version: 1
    Name: CGC_name: rnp-2 Person_evidence: WBPerson421
      Sequence_name: K08D10.4
      Molecular_name: K08D10.4
        K08D10.4.1
        CE28597
      Other_name: CELE_K08D10.4 Accession_evidence: NDB BX284604
      Public_name: rnp-2
    DB_info: Database: AceView gene 4E937
        WormQTL gene WBGene00004385
        WormFlux gene WBGene00004385
        NDB locus_tag CELE_K08D10.4
        Panther gene CAEEL|WormBase=WBGene00004385|UniProtKB=Q21322
          family PTHR10501
        NCBI gene 177181
        RefSeq protein NM_068103.5
        TREEFAM TREEFAM_ID TF313834
        TrEMBL UniProtAcc Q21322
        UniProt_GCRP UniProtAcc Q21322
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rnp
    Allele (53)
    Strain: WBStrain00003826
      WBStrain00003827
      WBStrain00003828
      WBStrain00007975
    RNASeq_FPKM (74)
    GO_annotation: 00071282
      00071283
      00071284
      00071285
      00071286
      00112745
      00112746
    Contained_in_operon: CEOP4116
    Ortholog (39)
    Paralog: WBGene00003172 Caenorhabditis elegans From_analysis: Panther
      WBGene00004386 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: rnp-2 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-2/U1A, which associates with U1 snRNPs; rnp-2 is coexpressed with rnp-3, dnj-15, and K08D10.12 in an operon; RNP-2 and RNP-3 are paralogs with ~50% identity that are more closely related to one another than to non-nematode orthologs; despite their association with distinct snRNPs, RNP-2 and RNP-3 are functionally interchangeable in vivo; either rnp-2(RNAi) or rnp-3(ok1424) animals are viable, with only rnp-2(RNAi) rnp-3(ok1424) animals showing lethality; moreover, RNAi against only RNP-3 causes RNP-2 to associate with RNP-3's normal U2 snRNP partners. Paper_evidence: WBPaper00005959
            WBPaper00029444
          Curator_confirmed: WBPerson567
          Date_last_updated: 06 Jun 2007 00:00:00
      Automated_description: Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in Alzheimer's disease; connective tissue disease; and disease of cellular proliferation. Is an ortholog of human SNRPA (small nuclear ribonucleoprotein polypeptide A) and SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11151)
      DOID:14566 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11155)
      DOID:65 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11151,HGNC:11155)
  Molecular_info: Corresponding_CDS: K08D10.4
    Corresponding_transcript: K08D10.4.1
    Other_sequence (47)
    Associated_feature: WBsf645908
      WBsf659785
      WBsf996195
      WBsf228165
  Experimental_info: RNAi_result: WBRNAi00069261 Inferred_automatically: RNAi_primary
      WBRNAi00080121 Inferred_automatically: RNAi_primary
      WBRNAi00103695 Inferred_automatically: RNAi_primary
      WBRNAi00080031 Inferred_automatically: RNAi_primary
      WBRNAi00083524 Inferred_automatically: RNAi_primary
      WBRNAi00016787 Inferred_automatically: RNAi_primary
      WBRNAi00061850 Inferred_automatically: RNAi_primary
      WBRNAi00034120 Inferred_automatically: RNAi_primary
      WBRNAi00085058 Inferred_automatically: RNAi_primary
      WBRNAi00069259 Inferred_automatically: RNAi_primary
      WBRNAi00069260 Inferred_automatically: RNAi_primary
      WBRNAi00083738 Inferred_automatically: RNAi_primary
      WBRNAi00083582 Inferred_automatically: RNAi_primary
      WBRNAi00080033 Inferred_automatically: RNAi_primary
      WBRNAi00080119 Inferred_automatically: RNAi_primary
      WBRNAi00083491 Inferred_automatically: RNAi_primary
      WBRNAi00069262 Inferred_automatically: RNAi_primary
      WBRNAi00083776 Inferred_automatically: RNAi_primary
      WBRNAi00050254 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012050
      Expr1032196
      Expr1153952
      Expr2015391
      Expr2033625
    Drives_construct: WBCnstr00000641
      WBCnstr00000642
      WBCnstr00035521
    Construct_product: WBCnstr00000641
      WBCnstr00000642
      WBCnstr00035521
    Microarray_results (20)
    Expression_cluster (98)
    Interaction: WBInteraction000032927
      WBInteraction000033482
      WBInteraction000034944
      WBInteraction000035288
      WBInteraction000036596
      WBInteraction000038361
      WBInteraction000038692
      WBInteraction000038869
      WBInteraction000039183
      WBInteraction000040569
      WBInteraction000042039
      WBInteraction000042135
      WBInteraction000042312
      WBInteraction000043417
      WBInteraction000045442
      WBInteraction000046053
      WBInteraction000046207
      WBInteraction000046934
      WBInteraction000051875
      WBInteraction000051908
      WBInteraction000109709
      WBInteraction000125398
      WBInteraction000125399
      WBInteraction000125400
      WBInteraction000125401
      WBInteraction000125427
      WBInteraction000125448
      WBInteraction000125881
      WBInteraction000126849
      WBInteraction000126850
      WBInteraction000126851
      WBInteraction000127630
      WBInteraction000127778
      WBInteraction000128286
      WBInteraction000128378
      WBInteraction000128411
      WBInteraction000128601
      WBInteraction000128856
      WBInteraction000128857
      WBInteraction000128858
      WBInteraction000128859
      WBInteraction000128860
      WBInteraction000128861
      WBInteraction000128862
      WBInteraction000128863
      WBInteraction000128864
      WBInteraction000128865
      WBInteraction000128866
      WBInteraction000128867
      WBInteraction000128868
      WBInteraction000128869
      WBInteraction000128870
      WBInteraction000128871
      WBInteraction000128872
      WBInteraction000128873
      WBInteraction000128874
      WBInteraction000128875
      WBInteraction000128876
      WBInteraction000128877
      WBInteraction000128878
      WBInteraction000128879
      WBInteraction000128880
      WBInteraction000128885
      WBInteraction000128943
      WBInteraction000130192
      WBInteraction000130243
      WBInteraction000130653
      WBInteraction000130721
      WBInteraction000130875
      WBInteraction000130963
      WBInteraction000131140
      WBInteraction000131235
      WBInteraction000131326
      WBInteraction000131845
      WBInteraction000131958
      WBInteraction000132039
      WBInteraction000132141
      WBInteraction000132281
      WBInteraction000132336
      WBInteraction000132411
      WBInteraction000132463
      WBInteraction000132537
      WBInteraction000132680
      WBInteraction000158680
      WBInteraction000158681
      WBInteraction000158682
      WBInteraction000158683
      WBInteraction000158724
      WBInteraction000158732
      WBInteraction000158795
      WBInteraction000158816
      WBInteraction000159091
      WBInteraction000169711
      WBInteraction000187978
      WBInteraction000190326
      WBInteraction000196578
      WBInteraction000243621
      WBInteraction000262740
      WBInteraction000272470
      WBInteraction000272988
      WBInteraction000276748
      WBInteraction000283653
      WBInteraction000285232
      WBInteraction000287330
      WBInteraction000288385
      WBInteraction000288386
      WBInteraction000289928
      WBInteraction000311254
      WBInteraction000323246
      WBInteraction000335513
      WBInteraction000348642
      WBInteraction000349338
      WBInteraction000350600
      WBInteraction000351836
      WBInteraction000386387
      WBInteraction000397296
      WBInteraction000411222
      WBInteraction000447449
      WBInteraction000462568
      WBInteraction000464603
      WBInteraction000465063
      WBInteraction000465083
      WBInteraction000468106
      WBInteraction000469093
      WBInteraction000470038
      WBInteraction000471148
      WBInteraction000471152
      WBInteraction000474444
      WBInteraction000525380
      WBInteraction000539138
      WBInteraction000567456
      WBInteraction000568239
  Map_info: Map: IV Position: -0.469588 Error: 0.052915
    Positive: Positive_clone: K08D10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4746
        4997
    Pseudo_map_position
  Reference: WBPaper00026593
    WBPaper00029444
    WBPaper00030488
    WBPaper00038354
    WBPaper00038491
    WBPaper00054464
    WBPaper00055090
    WBPaper00065026
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene