WormBase Tree Display for Gene: WBGene00001396

WBGene00001396 SMap: S_parent: Sequence: T13F2
  Identity: Version: 1
    Name: CGC_name: fat-4
      Sequence_name: T13F2.1
      Molecular_name: T13F2.1a
        T13F2.1a.1
        CE25113
        T13F2.1b
        CE44752
        T13F2.1c
        CE45810
        T13F2.1b.1
        T13F2.1c.1
      Other_name: CELE_T13F2.1 Accession_evidence: NDB BX284604
      Public_name: fat-4
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fat
    Allele (39)
    Legacy_information: [Napier JA] No mutants known. Encodes predicted delta6 fatty acid desaturase, protein expressed in yeast confers ability to desaturate linoleic acid to gamma-linolenic acid.
    Strain: WBStrain00031739
      WBStrain00004009
      WBStrain00004013
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (38)
    Paralog: WBGene00001395 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: fat-4 encodes a delta-5 fatty acid desaturase; when expressed heterologously in S. cerevisiae, FAT-4 converts di-homo-gamma-linolenic acid (20:3delta8,11,14) to arachidonic acid (20:4delta5,8,11,14), an important precursor in eicosanoid metabolism, as well as on other fatty acids (C18 to C20); FAT-4 is is required in vivo for delta-5 unsaturated fatty acid synthesis. Paper_evidence: WBPaper00003387
            WBPaper00003999
            WBPaper00005233
            WBPaper00013538
            WBPaper00013550
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in nerve ring and touch receptor neurons. Used to study alcohol use disorder. Is an ortholog of human FADS1 (fatty acid desaturase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00045655
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2019 00:00:00
  Models_disease_asserted: WBDOannot00000698
  Molecular_info: Corresponding_CDS: T13F2.1a
      T13F2.1b
      T13F2.1c
    Corresponding_transcript: T13F2.1a.1
      T13F2.1b.1
      T13F2.1c.1
    Other_sequence: AF078796
      AF114440
      Tcol_isotig05398
      HGC03092_1
      CRC01192_1
      DIC01651_1
      SC00641
      CBC06976_1
      CJC07434_1
      PPC01648_1
      CR00529
      Acan_isotig01226
      BXC03750_1
      Acan_isotig01225
      Tcol_isotig05394
      CBC00500_1
      Acan_isotig01227
      Oden_isotig10998
      Dviv_isotig18302
      PPC17128_1
      PP02517
      Dviv_isotig18301
      CJC11623_1
      ES743060.1
      Name_isotig01067
      Tcol_isotig05395
      Tcir_isotig07619
      Oden_isotig10996
      Hbac_isotig01349
      DI02017
      CBC01504_1
      Tcol_isotig05397
      HBC01269_1
      GR977199.1
      PPC08559_1
      CR01878
      OOC03752_1
      FK807949.1
      EX915713.1
      FK804967.1
      Oden_isotig10997
      Tcol_isotig05396
    Associated_feature: WBsf660530
      WBsf978988
      WBsf228877
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr11477
      Expr1017191
      Expr1030836
      Expr1156851
      Expr2011437
      Expr2029675
    Drives_construct: WBCnstr00019043
      WBCnstr00036973
    Construct_product: WBCnstr00036973
    Microarray_results (27)
    Expression_cluster (169)
    Interaction: WBInteraction000109917
      WBInteraction000122655
      WBInteraction000122656
      WBInteraction000123450
      WBInteraction000123452
      WBInteraction000145864
      WBInteraction000147381
      WBInteraction000149059
      WBInteraction000150477
      WBInteraction000151702
      WBInteraction000181257
      WBInteraction000195727
      WBInteraction000197905
      WBInteraction000198396
      WBInteraction000204017
      WBInteraction000206414
      WBInteraction000208192
      WBInteraction000209559
      WBInteraction000211778
      WBInteraction000215978
      WBInteraction000217671
      WBInteraction000220496
      WBInteraction000223451
      WBInteraction000226007
      WBInteraction000226177
      WBInteraction000226725
      WBInteraction000226802
      WBInteraction000230900
      WBInteraction000231500
      WBInteraction000232730
      WBInteraction000234629
      WBInteraction000235941
      WBInteraction000238233
      WBInteraction000241431
      WBInteraction000247891
      WBInteraction000248081
      WBInteraction000250552
      WBInteraction000251541
      WBInteraction000253445
      WBInteraction000254743
      WBInteraction000254856
      WBInteraction000258423
      WBInteraction000259111
      WBInteraction000261942
      WBInteraction000263187
      WBInteraction000263205
      WBInteraction000268357
      WBInteraction000269085
      WBInteraction000271897
      WBInteraction000272696
      WBInteraction000273187
      WBInteraction000273425
      WBInteraction000275228
      WBInteraction000277971
      WBInteraction000279976
      WBInteraction000281541
      WBInteraction000281697
      WBInteraction000282196
      WBInteraction000284259
      WBInteraction000285665
      WBInteraction000286977
      WBInteraction000288835
      WBInteraction000290020
      WBInteraction000290347
      WBInteraction000291148
      WBInteraction000291436
      WBInteraction000291567
      WBInteraction000293102
      WBInteraction000294203
      WBInteraction000294248
      WBInteraction000295654
      WBInteraction000297443
      WBInteraction000298504
      WBInteraction000298721
      WBInteraction000299603
      WBInteraction000301456
      WBInteraction000304730
      WBInteraction000305717
      WBInteraction000310047
      WBInteraction000310406
      WBInteraction000312212
      WBInteraction000315454
      WBInteraction000315469
      WBInteraction000317148
      WBInteraction000317251
      WBInteraction000319021
      WBInteraction000321071
      WBInteraction000321547
      WBInteraction000322399
      WBInteraction000324524
      WBInteraction000325507
      WBInteraction000328172
      WBInteraction000329260
      WBInteraction000329532
      WBInteraction000331625
      WBInteraction000339070
      WBInteraction000339114
      WBInteraction000339419
      WBInteraction000343214
      WBInteraction000343531
      WBInteraction000344169
      WBInteraction000344343
      WBInteraction000344441
      WBInteraction000344714
      WBInteraction000345354
      WBInteraction000346452
      WBInteraction000346913
      WBInteraction000349627
      WBInteraction000350197
      WBInteraction000350567
      WBInteraction000351720
      WBInteraction000352797
      WBInteraction000353431
      WBInteraction000356094
      WBInteraction000358239
      WBInteraction000358866
      WBInteraction000359194
      WBInteraction000359335
      WBInteraction000365957
      WBInteraction000368884
      WBInteraction000370885
      WBInteraction000371629
      WBInteraction000376589
      WBInteraction000377410
      WBInteraction000381240
      WBInteraction000382503
      WBInteraction000385676
      WBInteraction000386223
      WBInteraction000386443
      WBInteraction000386645
      WBInteraction000392750
      WBInteraction000393769
      WBInteraction000393897
      WBInteraction000395622
      WBInteraction000397248
      WBInteraction000400662
      WBInteraction000403290
      WBInteraction000405619
      WBInteraction000405855
      WBInteraction000409368
      WBInteraction000411712
      WBInteraction000417351
      WBInteraction000417477
      WBInteraction000417690
      WBInteraction000420324
      WBInteraction000424162
      WBInteraction000424741
      WBInteraction000426447
      WBInteraction000426977
      WBInteraction000428304
      WBInteraction000429167
      WBInteraction000433771
      WBInteraction000434821
      WBInteraction000434847
      WBInteraction000435485
      WBInteraction000441048
      WBInteraction000444182
      WBInteraction000456276
      WBInteraction000457272
      WBInteraction000457860
      WBInteraction000459248
      WBInteraction000459503
      WBInteraction000504206
      WBInteraction000517799
      WBInteraction000524508
      WBInteraction000525144
      WBInteraction000579994
      WBInteraction000585619
    WBProcess: WBbiopr:00000121
  Map_info (4)
  Reference (45)
  Remark: Extracted from Napier et al. (1998), fat-4 assigned as gene name.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene