WormBase Tree Display for Gene: WBGene00016990

WBGene00016990 SMap: S_parent: Sequence: CD4
  Identity: Version: 2
    Name: CGC_name: vps-37 Person_evidence: WBPerson3188
      Sequence_name: CD4.4
      Molecular_name: CD4.4
        CD4.4.1
        CE16952
      Other_name: CELE_CD4.4 Accession_evidence: NDB BX284605
      Public_name: vps-37
    DB_info: Database: AceView gene 5G71
        WormQTL gene WBGene00016990
        WormFlux gene WBGene00016990
        NDB locus_tag CELE_CD4.4
        Panther gene CAEEL|WormBase=WBGene00016990|UniProtKB=O44158
          family PTHR13678
        NCBI gene 178944
        RefSeq protein NM_072073.5
        TREEFAM TREEFAM_ID TF321840
        TrEMBL UniProtAcc O44158
        UniProt_GCRP UniProtAcc O44158
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 10 Sep 2007 09:52:01 WBPerson2970 Name_change: CGC_name: vps-37
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vps
    Allele (15)
    Strain: WBStrain00002948
      WBStrain00036336
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP5076
    Ortholog: WBGene00143038 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00085658 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00123253 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00157105 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00270695 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00220898 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2118 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g12211 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8951 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g15815 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g14184 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g18013 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g98 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2782 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21816 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g24621 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00038.g2142 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g19692 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold460.g1468 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      FL83_12024 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01364 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g23707 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50196900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g14270 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243207 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304355 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00265412 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00300923 Trichuris muris From_analysis: WormBase-Compara
      WBGene00302745 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000004109 Saccharomyces cerevisiae From_analysis: OrthoFinder
            Panther
      FB:FBgn0037299 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-060526-254 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-050913-110 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-061110-126 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-060526-166 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:26097 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:25754 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:18287 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:2147661 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2159402 Mus musculus From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:1916724 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
      RGD:1304576 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:1587769 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:11384366 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
    Structured_description: Concise_description: vps-37 encodes the C. elegans ortholog of Saccharomyces cerevisiae Srn2p/Vps37p, a member of the endosomal sorting ESCRT-I complex that functions in endosomal sorting of mono-ubiquitinated membrane proteins; in C. elegans, VPS-37 is an essential component of the ESCRT-I complex (other members include VPS-28, MVB-12, and TSG-101) that affects the rate at which cell surface receptors are degraded and hence, the rate at which their activity is downregulated; a VPS-37::GFP fusion protein localizes to the cytosol and to endosomal membranes. Paper_evidence: WBPaper00031035
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Jul 2010 00:00:00
      Automated_description: Involved in receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Is an ortholog of human VPS37B (VPS37B subunit of ESCRT-I). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: CD4.4
    Corresponding_transcript: CD4.4.1
    Other_sequence (14)
    Associated_feature: WBsf646815
      WBsf231771
  Experimental_info: RNAi_result (60)
    Expr_pattern: Expr5605
      Expr1018249
      Expr1037296
      Expr1147284
      Expr2018028
      Expr2036165
    Drives_construct: WBCnstr00003454
      WBCnstr00027652
    Construct_product: WBCnstr00000920
      WBCnstr00027652
    Microarray_results (20)
    Expression_cluster (105)
    Interaction: WBInteraction000007868
      WBInteraction000037194
      WBInteraction000049209
      WBInteraction000049211
      WBInteraction000049256
      WBInteraction000049257
      WBInteraction000163064
      WBInteraction000177105
      WBInteraction000179332
      WBInteraction000183180
      WBInteraction000234307
      WBInteraction000235474
      WBInteraction000256940
      WBInteraction000288200
      WBInteraction000291699
      WBInteraction000294154
      WBInteraction000319653
      WBInteraction000325317
      WBInteraction000334746
      WBInteraction000348955
      WBInteraction000397829
      WBInteraction000412576
      WBInteraction000413719
      WBInteraction000419279
      WBInteraction000419867
      WBInteraction000446696
      WBInteraction000522623
      WBInteraction000522624
      WBInteraction000522625
      WBInteraction000523149
      WBInteraction000523267
      WBInteraction000536637
      WBInteraction000536712
      WBInteraction000543631
      WBInteraction000543645
      WBInteraction000547224
  Map_info: Map: V Position: -1.37551 Error: 0.00596
    Positive: Positive_clone: CD4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027740
    WBPaper00031035
    WBPaper00031212
    WBPaper00031867
    WBPaper00038491
    WBPaper00038585
    WBPaper00039823
    WBPaper00055090
    WBPaper00064078
    WBPaper00064325
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene