WormBase Tree Display for Gene: WBGene00006996
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| WBGene00006996 | SMap | S_parent | Sequence | C08B11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | zyg-11 | Person_evidence | WBPerson698 | |||||
| Sequence_name | C08B11.1 | ||||||||
| Molecular_name | C08B11.1 | ||||||||
| C08B11.1.1 | |||||||||
| CE01471 | |||||||||
| Other_name | CELE_C08B11.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | zyg-11 | ||||||||
| DB_info | Database | AceView | gene | 2I309 | |||||
| WormQTL | gene | WBGene00006996 | |||||||
| WormFlux | gene | WBGene00006996 | |||||||
| NDB | locus_tag | CELE_C08B11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006996|UniProtKB=P21541 | |||||||
| family | PTHR12904 | ||||||||
| NCBI | gene | 174284 | |||||||
| RefSeq | protein | NM_063276.7 | |||||||
| SwissProt | UniProtAcc | P21541 | |||||||
| TREEFAM | TREEFAM_ID | TF313007 | |||||||
| UniProt_GCRP | UniProtAcc | P21541 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | zyg | ||||||||
| Reference_allele | WBVar00000349 | ||||||||
| Allele (45) | |||||||||
| Legacy_information | b2ts mm : L4 shift-up results in embryonic arrest symmetrical first cleavage; TSP before fertilization; L1 shift-up results in F1 embryonic arrest. Viable at 16x. NA5 (mn40amber (non-ts oocyte-defective eggs fertilized but do not hatch) etc.). | ||||||||
| [C.elegansII] mn40amb : maternal effect lethal, abnormal metaphase at meiosis II, symmetrical first cleavage, extensive early defects. OA>5: b2ts (TSP before fertilization; L1 shift-up Mel), it11ts, it1, it2 (weak), it28, it34 (mostly strict Mel), b290 (Mel, leaky, zygotic rescue). Cloned: transcripts not confined to germ line; encodes novel protein. [Kemphues et al. 1988; Carter et al. 1990; KK] | |||||||||
| Strain | WBStrain00034144 | ||||||||
| WBStrain00005802 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (22) | |||||||||
| Structured_description | Concise_description | zyg-11 encodes a protein containing four diverged leucine-rich repeats and an armadillo-like helical domain and is conserved in metazoa, but not found in Drosophila; during development, ZYG-11 functions as the substrate-recognition subunit for a CUL-2-based ubiquitin-ligase complex that is required for a number of biological processes including progression through meiotic anaphase II, mitotic chromosome condensation, and establishment of anterior/posterior polarity in the early embryo; ZYG-11 interacts with CUL-2 in vivo and with ELC-1/elongin C in vitro. | Paper_evidence | WBPaper00000867 | |||||
| WBPaper00001265 | |||||||||
| WBPaper00024321 | |||||||||
| WBPaper00024430 | |||||||||
| WBPaper00029122 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables cyclin binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation. Part of Cul2-RING ubiquitin ligase complex. Is an ortholog of human ZYG11B (zyg-11 family member B, cell cycle regulator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C08B11.1 | |||||||
| Corresponding_transcript | C08B11.1.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf657923 | ||||||||
| WBsf976496 | |||||||||
| WBsf976497 | |||||||||
| WBsf976498 | |||||||||
| WBsf981231 | |||||||||
| WBsf988633 | |||||||||
| WBsf988634 | |||||||||
| WBsf221670 | |||||||||
| WBsf221671 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1021831 | ||||||||
| Expr1032992 | |||||||||
| Expr1144124 | |||||||||
| Expr2018209 | |||||||||
| Expr2036347 | |||||||||
| Drives_construct | WBCnstr00034047 | ||||||||
| Construct_product | WBCnstr00001756 | ||||||||
| WBCnstr00001757 | |||||||||
| WBCnstr00034047 | |||||||||
| Antibody | WBAntibody00001233 | ||||||||
| WBAntibody00002713 | |||||||||
| WBAntibody00002714 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (164) | |||||||||
| Map_info | Map | II | Position | 0.63818 | Error | 0.002141 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C08B11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C47C7 | |||||||||
| YK852 | |||||||||
| Mapping_data | 2_point | 775 | |||||||
| 776 | |||||||||
| 779 | |||||||||
| 780 | |||||||||
| 781 | |||||||||
| 782 | |||||||||
| Multi_point (9) | |||||||||
| Pos_neg_data (17) | |||||||||
| Reference (49) | |||||||||
| Method | Gene |
