WormBase Tree Display for Gene: WBGene00006994
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WBGene00006994 | SMap | S_parent | Sequence | F22B5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | zyg-9 | Person_evidence | WBPerson698 | |||||
Sequence_name | F22B5.7 | ||||||||
Molecular_name (3) | |||||||||
Other_name | CELE_F22B5.7 | Accession_evidence | NDB | BX284602 | |||||
Public_name | zyg-9 | ||||||||
DB_info | Database | AceView | gene | 2I753 | |||||
WormQTL | gene | WBGene00006994 | |||||||
WormFlux | gene | WBGene00006994 | |||||||
NDB | locus_tag | CELE_F22B5.7 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006994|UniProtKB=G5EEM5 | |||||||
family | PTHR12609 | ||||||||
NCBI | gene | 174350 | |||||||
RefSeq | protein | NM_063383.7 | |||||||
SwissProt | UniProtAcc | G5EEM5 | |||||||
TREEFAM | TREEFAM_ID | TF105639 | |||||||
UniProt_GCRP | UniProtAcc | G5EEM5 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | zyg | ||||||||
Reference_allele | WBVar00000370 | ||||||||
Allele (80) | |||||||||
Legacy_information | b244ts mm : L4 shift-up results in embryonic arrest at > 200 nuclei; first cleavage variably abnormal skewed. TSP short approximately during first cleavage. L1 shift-up results in viable adult F1 embryonic arrest does not affect male fertility. Viable at 16x. NA1. | ||||||||
[C.elegansII] b244ts : maternal effect embryonic lethal after larval shift-up; meiotic and mitotic spindle abnormalities, defects in first mitotic divisions, like mei-1(gf), mel-26(gf). OA>5: it3 (Mel, no zygotic rescue), b288ts,mm,b279, b301, b307. [Kemphues et al. 1988; Mains et al. 1990; HR; KK] | |||||||||
Strain | WBStrain00003033 | ||||||||
WBStrain00005815 | |||||||||
WBStrain00007348 | |||||||||
WBStrain00007356 | |||||||||
WBStrain00007371 | |||||||||
WBStrain00050673 | |||||||||
WBStrain00054737 | |||||||||
WBStrain00054738 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (48) | |||||||||
Contained_in_operon | CEOP2348 | ||||||||
Ortholog (49) | |||||||||
Paralog | WBGene00011613 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00018781 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1. | Paper_evidence | WBPaper00003099 | |||||
WBPaper00006059 | |||||||||
WBPaper00006060 | |||||||||
WBPaper00006061 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Mar 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable microtubule binding activity and microtubule plus end polymerase. Involved in embryo development; meiotic spindle organization; and spindle elongation. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Is an ortholog of human CKAP5 (cytoskeleton associated protein 5). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | F22B5.7 | |||||||
Corresponding_transcript | F22B5.7.1 | ||||||||
Other_sequence (20) | |||||||||
Associated_feature | WBsf644468 | ||||||||
WBsf644469 | |||||||||
WBsf657974 | |||||||||
WBsf657975 | |||||||||
WBsf988740 | |||||||||
WBsf988741 | |||||||||
WBsf221744 | |||||||||
WBsf221745 | |||||||||
WBsf221746 | |||||||||
Experimental_info | RNAi_result (36) | ||||||||
Expr_pattern | Chronogram1255 | ||||||||
Expr2682 | |||||||||
Expr1019278 | |||||||||
Expr1032991 | |||||||||
Expr1149212 | |||||||||
Expr2018213 | |||||||||
Expr2036351 | |||||||||
Drives_construct | WBCnstr00003533 | ||||||||
WBCnstr00034048 | |||||||||
Construct_product | WBCnstr00034048 | ||||||||
Antibody | WBAntibody00000179 | ||||||||
WBAntibody00000286 | |||||||||
WBAntibody00000444 | |||||||||
WBAntibody00000490 | |||||||||
WBAntibody00001398 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (152) | |||||||||
Interaction (118) | |||||||||
Map_info | Map | II | Position | 0.81178 | Error | 0.00024 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C28G11 | |||||||
F22B5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 546 | |||||||
Multi_point | 475 | ||||||||
1389 | |||||||||
4436 | |||||||||
Pos_neg_data | 3782 | ||||||||
3783 | |||||||||
3784 | |||||||||
3785 | |||||||||
3786 | |||||||||
Reference (119) | |||||||||
Method | Gene |