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WormBase Tree Display for Gene: WBGene00006994

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Name Class

WBGene00006994SMapS_parentSequenceF22B5
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classzyg
Reference_alleleWBVar00000370
Allele (80)
Legacy_informationb244ts mm : L4 shift-up results in embryonic arrest at > 200 nuclei; first cleavage variably abnormal skewed. TSP short approximately during first cleavage. L1 shift-up results in viable adult F1 embryonic arrest does not affect male fertility. Viable at 16x. NA1.
[C.elegansII] b244ts : maternal effect embryonic lethal after larval shift-up; meiotic and mitotic spindle abnormalities, defects in first mitotic divisions, like mei-1(gf), mel-26(gf). OA>5: it3 (Mel, no zygotic rescue), b288ts,mm,b279, b301, b307. [Kemphues et al. 1988; Mains et al. 1990; HR; KK]
StrainWBStrain00003033
WBStrain00005815
WBStrain00007348
WBStrain00007356
WBStrain00007371
WBStrain00050673
WBStrain00054737
WBStrain00054738
RNASeq_FPKM (74)
GO_annotation (48)
Contained_in_operonCEOP2348
Ortholog (49)
ParalogWBGene00011613Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018781Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionzyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1.Paper_evidenceWBPaper00003099
WBPaper00006059
WBPaper00006060
WBPaper00006061
Curator_confirmedWBPerson1843
Date_last_updated17 Mar 2006 00:00:00
Automated_descriptionPredicted to enable microtubule binding activity and microtubule plus end polymerase. Involved in embryo development; meiotic spindle organization; and spindle elongation. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Is an ortholog of human CKAP5 (cytoskeleton associated protein 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF22B5.7
Corresponding_transcriptF22B5.7.1
Other_sequence (20)
Associated_featureWBsf644468
WBsf644469
WBsf657974
WBsf657975
WBsf988740
WBsf988741
WBsf221744
WBsf221745
WBsf221746
Experimental_infoRNAi_result (36)
Expr_patternChronogram1255
Expr2682
Expr1019278
Expr1032991
Expr1149212
Expr2018213
Expr2036351
Drives_constructWBCnstr00003533
WBCnstr00034048
Construct_productWBCnstr00034048
AntibodyWBAntibody00000179
WBAntibody00000286
WBAntibody00000444
WBAntibody00000490
WBAntibody00001398
Microarray_results (22)
Expression_cluster (152)
Interaction (118)
Map_infoMapIIPosition0.81178Error0.00024
Well_ordered
PositivePositive_cloneC28G11
F22B5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point546
Multi_point475
1389
4436
Pos_neg_data3782
3783
3784
3785
3786
Reference (119)
MethodGene