WormBase Tree Display for Gene: WBGene00006994
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WBGene00006994 | SMap | S_parent | Sequence | F22B5 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | zyg | ||||||
Reference_allele | WBVar00000370 | ||||||
Allele (80) | |||||||
Legacy_information | b244ts mm : L4 shift-up results in embryonic arrest at > 200 nuclei; first cleavage variably abnormal skewed. TSP short approximately during first cleavage. L1 shift-up results in viable adult F1 embryonic arrest does not affect male fertility. Viable at 16x. NA1. | ||||||
[C.elegansII] b244ts : maternal effect embryonic lethal after larval shift-up; meiotic and mitotic spindle abnormalities, defects in first mitotic divisions, like mei-1(gf), mel-26(gf). OA>5: it3 (Mel, no zygotic rescue), b288ts,mm,b279, b301, b307. [Kemphues et al. 1988; Mains et al. 1990; HR; KK] | |||||||
Strain | WBStrain00003033 | ||||||
WBStrain00005815 | |||||||
WBStrain00007348 | |||||||
WBStrain00007356 | |||||||
WBStrain00007371 | |||||||
WBStrain00050673 | |||||||
WBStrain00054737 | |||||||
WBStrain00054738 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (48) | |||||||
Contained_in_operon | CEOP2348 | ||||||
Ortholog (49) | |||||||
Paralog | WBGene00011613 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00018781 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1. | Paper_evidence | WBPaper00003099 | |||
WBPaper00006059 | |||||||
WBPaper00006060 | |||||||
WBPaper00006061 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Mar 2006 00:00:00 | ||||||
Automated_description | Predicted to enable microtubule binding activity and microtubule plus end polymerase. Involved in embryo development; meiotic spindle organization; and spindle elongation. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Is an ortholog of human CKAP5 (cytoskeleton associated protein 5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F22B5.7 | |||||
Corresponding_transcript | F22B5.7.1 | ||||||
Other_sequence (20) | |||||||
Associated_feature | WBsf644468 | ||||||
WBsf644469 | |||||||
WBsf657974 | |||||||
WBsf657975 | |||||||
WBsf988740 | |||||||
WBsf988741 | |||||||
WBsf221744 | |||||||
WBsf221745 | |||||||
WBsf221746 | |||||||
Experimental_info | RNAi_result (36) | ||||||
Expr_pattern | Chronogram1255 | ||||||
Expr2682 | |||||||
Expr1019278 | |||||||
Expr1032991 | |||||||
Expr1149212 | |||||||
Expr2018213 | |||||||
Expr2036351 | |||||||
Drives_construct | WBCnstr00003533 | ||||||
WBCnstr00034048 | |||||||
Construct_product | WBCnstr00034048 | ||||||
Antibody | WBAntibody00000179 | ||||||
WBAntibody00000286 | |||||||
WBAntibody00000444 | |||||||
WBAntibody00000490 | |||||||
WBAntibody00001398 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (152) | |||||||
Interaction (118) | |||||||
Map_info | Map | II | Position | 0.81178 | Error | 0.00024 | |
Well_ordered | |||||||
Positive | Positive_clone | C28G11 | |||||
F22B5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 546 | |||||
Multi_point | 475 | ||||||
1389 | |||||||
4436 | |||||||
Pos_neg_data | 3782 | ||||||
3783 | |||||||
3784 | |||||||
3785 | |||||||
3786 | |||||||
Reference (119) | |||||||
Method | Gene |