WormBase Tree Display for Gene: WBGene00006774
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WBGene00006774 | SMap | S_parent | Sequence | F21F3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143072 | ||||||
Allele (68) | |||||||
Legacy_information | e264 : weak kinker sluggish slightly dumpyish sometimes Egl resistant to 1mM levamisole in body but not in head; sensitive to hypoosmotic shock. ES3 ME2. NA > 40 (e213 x20 etc.). | ||||||
See also e213, e229, e243, e294 | |||||||
[C.elegansII] e264 : weak kinker, sluggish, slightly dumpyish sometimes Egl, resistant to 1mM levamisole in body but not in head; sensitive to hypoosmotic shock. ES3 ME2. OA>40: e213, e743, x20, etc. Cloned: encodes subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980; ZZ] | |||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (40) | |||||||
Ortholog (69) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with ACR-2, ACR-3, UNC-29, and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively. | Paper_evidence | WBPaper00000031 | |||
WBPaper00002294 | |||||||
WBPaper00002860 | |||||||
WBPaper00003080 | |||||||
WBPaper00003425 | |||||||
WBPaper00005223 | |||||||
WBPaper00005594 | |||||||
WBPaper00026635 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 12 Sep 2006 00:00:00 | ||||||
Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; neuromuscular synaptic transmission; and regulation of multicellular organismal process. Located in neuron projection and postsynaptic membrane. Expressed in several structures, including body wall musculature; copulatory spicule; enteric muscle; oblique male muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (17) | ||||||
Molecular_info | Corresponding_CDS | F21F3.5 | |||||
Corresponding_transcript | F21F3.5.1 | ||||||
Other_sequence (47) | |||||||
Associated_feature | WBsf649123 | ||||||
WBsf983531 | |||||||
WBsf983532 | |||||||
WBsf1009728 | |||||||
WBsf219329 | |||||||
WBsf219330 | |||||||
Experimental_info | RNAi_result (12) | ||||||
Expr_pattern (12) | |||||||
Drives_construct (14) | |||||||
Construct_product (15) | |||||||
Antibody | WBAntibody00001428 | ||||||
WBAntibody00001985 | |||||||
WBAntibody00002833 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (169) | |||||||
Interaction (32) | |||||||
Map_info | Map | I | Position | -0.653265 | Error | 0.013847 | |
Well_ordered | |||||||
Positive | Inside_rearr | gaDp1 | |||||
Positive_clone | F21F3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
ZZ#11 | |||||||
Mapping_data | 2_point (4) | ||||||
Multi_point (24) | |||||||
Pos_neg_data | 332 | ||||||
5038 | |||||||
5039 | |||||||
5040 | |||||||
5093 | |||||||
6023 | |||||||
6024 | |||||||
Reference (161) | |||||||
Method | Gene |