WormBase Tree Display for Gene: WBGene00006773
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WBGene00006773 | SMap | S_parent | Sequence | W02D3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143071 | ||||||
Allele (43) | |||||||
Legacy_information | e262 : weak coiler fairly active. ES2 ME1. NA1. | ||||||
s80 : L1 lethal. NA1. | |||||||
L1 lethal | |||||||
See also s80 | |||||||
[C.elegansII] e262 : weak coiler, fairly active; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993; NC] | |||||||
Strain (15) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (35) | |||||||
Contained_in_operon | CEOP1348 | ||||||
Ortholog (54) | |||||||
Structured_description | Concise_description | unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex. | Paper_evidence | WBPaper00002798 | |||
WBPaper00005042 | |||||||
WBPaper00005136 | |||||||
WBPaper00030973 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 07 May 2010 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in chemical synaptic transmission; regulation of axonogenesis; and regulation of synapse structure or activity. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30788) | ||
Molecular_info | Corresponding_CDS | W02D3.9 | |||||
Corresponding_transcript | W02D3.9.1 | ||||||
Other_sequence (80) | |||||||
Associated_feature | WBsf034259 | ||||||
WBsf649254 | |||||||
WBsf664356 | |||||||
WBsf664357 | |||||||
WBsf664358 | |||||||
WBsf983991 | |||||||
WBsf1009987 | |||||||
WBsf219629 | |||||||
WBsf219630 | |||||||
Transcription_factor | WBTranscriptionFactor000434 | ||||||
Experimental_info | RNAi_result (34) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00002546 | ||||||
WBCnstr00004371 | |||||||
WBCnstr00006094 | |||||||
WBCnstr00006107 | |||||||
WBCnstr00006110 | |||||||
WBCnstr00010892 | |||||||
Construct_product | WBCnstr00006110 | ||||||
WBCnstr00010892 | |||||||
Antibody | WBAntibody00000145 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (138) | |||||||
Interaction (324) | |||||||
Map_info | Map | I | Position | 1.30432 | Error | 0.000643 | |
Well_ordered | |||||||
Positive | Inside_rearr | qDf16 | |||||
nDp1 | |||||||
Positive_clone | W02D3 | Person_evidence | WBPerson422 | ||||
WBPerson43 | |||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point (2) | ||||||
Multi_point (24) | |||||||
Pos_neg_data (41) | |||||||
Reference (129) | |||||||
Remark | [Miller D and Barnes T] unc-37 encodes a homolog of Drosophila groucho and therefore is likely to function as a transcription cofactor protein. | ||||||
Method | Gene |