WormBase Tree Display for Gene: WBGene00004963
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WBGene00004963 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | spe-9 | Person_evidence | WBPerson252 | |||||
Sequence_name | C17D12.6 | ||||||||
Molecular_name | C17D12.6a | ||||||||
C17D12.6a.1 | |||||||||
CE27074 | |||||||||
C17D12.6b | |||||||||
CE42755 | |||||||||
C17D12.6b.1 | |||||||||
Other_name | CELE_C17D12.6 | Accession_evidence | NDB | BX284601 | |||||
Public_name | spe-9 | ||||||||
DB_info | Database (10) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | spe | ||||||||
Reference_allele | WBVar00087760 | ||||||||
Allele (69) | |||||||||
Legacy_information | hc52ts : hermaphrodites and males grown at 25x produce motile sperm that are fertilization defective. Self-fertility < 1% (25x) 100% (16x). ES2 (adult). NA2 (hc88ts). | ||||||||
[C.elegansII] hc52ts : hermaphrodites and males grown at 25C produce motile sperm that are fertilization defective. Self-fertility < 1% (25C) 100% (16C). ES2 (adult). OA3: hc88ts,also nonconditional alleles. [L'Hernault et al. 1988; SL] | |||||||||
[Singson A] Encodes putative transmembrane protein of 661 aa, with 10 EGF-like repeats. Predicted gene C17D12.6 | |||||||||
Strain | WBStrain00034092 | ||||||||
WBStrain00034093 | |||||||||
WBStrain00034899 | |||||||||
WBStrain00034903 | |||||||||
WBStrain00034904 | |||||||||
WBStrain00034905 | |||||||||
WBStrain00000377 | |||||||||
WBStrain00000379 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (26) | |||||||||
Paralog (13) | |||||||||
Structured_description | Concise_description | spe-9 encodes an EGF repeat-containing protein with a short intracellular domain; SPE-9 is required autonomously in sperm for fertilization, and by homology, likely mediates an adhesive or signaling event necessary for proper oocyte fertilization; spe-9 mRNA is detected solely in animals that are engaged in spermatogenesis; in spermatids, SPE-9 is found at or near the cell surface; following sperm activation, SPE-9 is found primarily on the pseudopod. | Paper_evidence | WBPaper00003039 | |||||
WBPaper00024323 | |||||||||
WBPaper00024329 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 14 Sep 2007 00:00:00 | ||||||||
Automated_description | Predicted to enable signaling receptor binding activity. Involved in single fertilization. Located in several cellular components, including cell surface; cytoplasm; and pseudopodium. Expressed in sperm and spermatid. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; limb ischemia; and temporal arteritis. Is an ortholog of human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:264 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||
DOID:8947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
DOID:0060227 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
DOID:13375 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2908) | ||||||
DOID:799 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
DOID:0050852 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
DOID:5241 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2910) | ||||||
Molecular_info | Corresponding_CDS | C17D12.6a | |||||||
C17D12.6b | |||||||||
Corresponding_CDS_history | C17D12.6:wp47 | ||||||||
Corresponding_transcript | C17D12.6a.1 | ||||||||
C17D12.6b.1 | |||||||||
Other_sequence | AF049327 | ||||||||
CR11084 | |||||||||
CR11085 | |||||||||
CRC07379_1 | |||||||||
Associated_feature | WBsf985327 | ||||||||
Experimental_info | RNAi_result | WBRNAi00002965 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00040793 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr3091 | ||||||||
Expr3092 | |||||||||
Expr3127 | |||||||||
Expr14495 | |||||||||
Expr1017417 | |||||||||
Expr1032471 | |||||||||
Expr1144831 | |||||||||
Expr2016051 | |||||||||
Expr2034286 | |||||||||
Construct_product | WBCnstr00017339 | ||||||||
Antibody | WBAntibody00000756 | ||||||||
WBAntibody00000878 | |||||||||
WBAntibody00000886 | |||||||||
WBAntibody00000887 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (124) | |||||||||
Interaction (52) | |||||||||
WBProcess | WBbiopr:00000067 | ||||||||
Map_info | Map | I | Position | 9.27255 | Error | 0.017081 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | hDf17 | |||||||
Positive_clone | C17D12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
R12G2 | Author_evidence | Singson AW | |||||||
Negative | Outside_rearr | dxDf2 | |||||||
Mapping_data | 2_point | 3197 | |||||||
Multi_point | 1046 | ||||||||
3106 | |||||||||
3107 | |||||||||
4272 | |||||||||
5471 | |||||||||
Pos_neg_data | 8359 | ||||||||
9332 | |||||||||
9416 | |||||||||
9417 | |||||||||
Reference (80) | |||||||||
Remark | spe-9(hc52) fully rescued by R12G2, partially rescued by C17D12. Data extracted from Singson et al. (1998) | ||||||||
Method | Gene |